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anti-CFH antibody :: Rabbit CFH Antibody

Scan QR to view Datasheet Catalog #    MBS8505511
Western Blot (WB)
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CFH, Antibody

 Also Known As   

CFH Antibody

 Product Synonym Names    ARMD4; ARMS1; CFHL3; FH; FHL1; HF; HF1; HF2; HUS; MGC88246
 Product Gene Name   

anti-CFH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    126700
 3D Structure    ModBase 3D Structure for P08603
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Immunogen    Recombinant protein of human CFH
 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-CFH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CFH antibody

   CFH (Complement factor H) is a member of the Regulator of Complement Activation (RCA) gene cluster and a protein with twenty short concensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this CFH have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy (1).
 Product Categories/Family for anti-CFH antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-CFH antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CFH antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Western Blot (WB) of anti-CFH antibody    Western blot analysis of extracts of HepG2cell line, using CFH antibody.
anti-CFH antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CFH. It may not necessarily be applicable to this product.
 NCBI GI #    62739186
 NCBI GeneID    3075
 NCBI Accession #    NP_000177.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000186.3 [Other Products]
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 UniProt Primary Accession #    P08603 [Other Products]
 UniProt Secondary Accession #    P78435; Q14570; Q2TAZ5; Q38G77; Q5TFM3; Q8N708; Q9NU86; A5PL14 [Other Products]
 UniProt Related Accession #    P08603 [Other Products]
 Molecular Weight    49kDa
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 NCBI Official Full Name    complement factor H isoform a
 NCBI Official Synonym Full Names    complement factor H
 NCBI Official Symbol    CFH [Similar Products]
 NCBI Official Synonym Symbols   
FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3
[Similar Products]
 NCBI Protein Information    complement factor H
 UniProt Protein Name    Complement factor H
 UniProt Synonym Protein Names   
H factor 1
 Protein Family    Complement factor
 UniProt Gene Name    CFH [Similar Products]
 UniProt Synonym Gene Names    HF; HF1; HF2 [Similar Products]
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 NCBI Summary for CFH    This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
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 UniProt Comments for CFH    Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.CautionAccording to a report, Asn-217 is not glycosylated (PubMed:17591618). Another study observed glycosylation at this position (PubMed:19139490).
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Product References and Citations for anti-CFH antibody

   1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1; 33:D54-8.
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 Research Articles on CFH    1. Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CFH antibodyDiseases associated with anti-CFH antibody
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Disease Name  Pubmed Publications
 Macular Degeneration Antibodies  >406 publications with CFH and Macular Degeneration
 Macular Degeneration, Age-Related, 4 Antibodies  >161 publications with CFH and Macular Degeneration, Age-Related, 4
 Kidney Diseases Antibodies  >131 publications with CFH and Kidney Diseases
 Atypical hemolytic uremic syndrome Antibodies  >87 publications with CFH and Atypical hemolytic uremic syndrome
 Inflammation Antibodies  >68 publications with CFH and Inflammation
 Cardiovascular Diseases Antibodies  >57 publications with CFH and Cardiovascular Diseases
 Atrophy Antibodies  >46 publications with CFH and Atrophy
 Glomerulonephritis, Membranoproliferative Antibodies  >36 publications with CFH and Glomerulonephritis, Membranoproliferative
 Mental Disorders Antibodies  >24 publications with CFH and Mental Disorders
 Hypertension Antibodies  >24 publications with CFH and Hypertension
Organs/Tissues associated with anti-CFH antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >202 publications with CFH and Eye
 Kidney Antibodies  >99 publications with CFH and Kidney
 Vascular Antibodies  >66 publications with CFH and Vascular
 Ear Antibodies  >37 publications with CFH and Ear
 Brain Antibodies  >32 publications with CFH and Brain
 Liver Antibodies  >28 publications with CFH and Liver
 Heart Antibodies  >24 publications with CFH and Heart
 Nerve Antibodies  >13 publications with CFH and Nerve
 Skin Antibodies  >11 publications with CFH and Skin
 Bone Antibodies  >7 publications with CFH and Bone
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