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anti-CIITA antibody :: Rabbit CIITA Antibody

Scan QR to view Datasheet Catalog #    MBS003268 anti-CIITA antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CIITA, Antibody

 Also Known As   

Rabbit CIITA Antibody

 Product Gene Name   

anti-CIITA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (10971055..11018840). Location: 16p13
 OMIM    209920
 3D Structure    ModBase 3D Structure for P33076
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-CIITA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CIITA antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CIITA. It may not necessarily be applicable to this product.
 NCBI GI #    156938336
 NCBI GeneID    4261
 NCBI Accession #    NP_000237.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000246.3 [Other Products]
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 UniProt Primary Accession #    P33076 [Other Products]
 UniProt Secondary Accession #    D3DUG0 [Other Products]
 UniProt Related Accession #    P33076 [Other Products]
 Molecular Weight    123,514 Da
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 NCBI Official Full Name    MHC class II transactivator
 NCBI Official Synonym Full Names    class II, major histocompatibility complex, transactivator
 NCBI Official Symbol    CIITA [Similar Products]
 NCBI Official Synonym Symbols   
C2TA; NLRA; MHC2TA; CIITAIV
[Similar Products]
 NCBI Protein Information    MHC class II transactivator; NLR family, acid domain containing; MHC class II transactivator type III; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
 UniProt Protein Name    MHC class II transactivator
 Protein Family    MHC class II transactivator
 UniProt Gene Name    CIITA [Similar Products]
 UniProt Synonym Gene Names    MHC2TA; CIITA [Similar Products]
 UniProt Entry Name    C2TA_HUMAN
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 NCBI Summary for CIITA    This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CIITA    CIITA: a non-DNA binding transactivator that functions both in constitutive and inducible MHC Class II expression. Defects are a cause of bare lymphocyte syndrome type II (BLS II), a form of severe combined immunodeficiency disease (SCID) characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, an absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production.

Protein type: DNA-binding; Transcription, coactivator/corepressor; EC 2.7.11.1

Chromosomal Location of Human Ortholog: 16p13

Cellular Component: nucleoplasm; PML body

Molecular Function: protein C-terminus binding; protein binding; GTP binding; DNA binding; transcription activator binding; transcription coactivator activity; protein complex binding; transferase activity, transferring acyl groups; kinase activity; ATP binding

Biological Process: response to antibiotic; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of MHC class II biosynthetic process; negative regulation of collagen biosynthetic process; positive regulation of transcription, DNA-dependent; positive regulation of MHC class I biosynthetic process; immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphorylation

Disease: Rheumatoid Arthritis; Bare Lymphocyte Syndrome, Type Ii
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 Research Articles on CIITA    1. In multiple sclerosis patients, MHC2TA mRNA levels could be decreased by the active replication of HHV-6; the absence of HHV-6 in serum and the increase of MHC2TA expression could be studied as markers of good clinical response to IFN-beta treatment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CIITA antibodyPathways associated with anti-CIITA antibody
 Reference Product  PubMed Publications
 RFX5 antibody  >52 publications with CIITA and RFX5
 RFXANK antibody  >25 publications with CIITA and RFXANK
 HDAC4 antibody  >3 publications with CIITA and HDAC4
 HDAC5 antibody  >2 publications with CIITA and HDAC5
 NFYB antibody  >1 publications with CIITA and NFYB
 NCOA1 antibody  >1 publications with CIITA and NCOA1
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
Diseases associated with anti-CIITA antibodyOrgans/Tissues associated with anti-CIITA antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >137 publications with CIITA and Neoplasms
 Inflammation Antibodies  >49 publications with CIITA and Inflammation
 Carcinoma Antibodies  >34 publications with CIITA and Carcinoma
 Neoplasms, Experimental Antibodies  >30 publications with CIITA and Neoplasms, Experimental
 Necrosis Antibodies  >29 publications with CIITA and Necrosis
 Arthritis, Rheumatoid Antibodies  >14 publications with CIITA and Arthritis, Rheumatoid
 Multiple Sclerosis Antibodies  >13 publications with CIITA and Multiple Sclerosis
 Kidney Diseases Antibodies  >11 publications with CIITA and Kidney Diseases
 Liver Diseases Antibodies  >11 publications with CIITA and Liver Diseases
 Breast Neoplasms Antibodies  >9 publications with CIITA and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >256 publications with CIITA and Blood
 Bone Marrow Antibodies  >28 publications with CIITA and Bone Marrow
 Lung Antibodies  >26 publications with CIITA and Lung
 Kidney Antibodies  >20 publications with CIITA and Kidney
 Spleen Antibodies  >19 publications with CIITA and Spleen
 Brain Antibodies  >16 publications with CIITA and Brain
 Heart Antibodies  >11 publications with CIITA and Heart
 Lymph Antibodies  >9 publications with CIITA and Lymph
 Lymph Node Antibodies  >9 publications with CIITA and Lymph Node
 Intestine Antibodies  >7 publications with CIITA and Intestine
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