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anti-CLCNKA antibody :: Rabbit anti-Human CLCNKA Antibody

Scan QR to view Datasheet Catalog #    MBS003776 anti-CLCNKA antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CLCNKA, Antibody

 Also Known As   

Rabbit CLCNKA Antibody

 Product Gene Name   

anti-CLCNKA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (16348486..16360545). Location: 1p36
 OMIM    602024
 3D Structure    ModBase 3D Structure for P51800
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 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-CLCNKA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CLCNKA antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CLCNKA. It may not necessarily be applicable to this product.
 NCBI GI #    112382222
 NCBI GeneID    1187
 NCBI Accession #    NP_001036169.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001042704.1 [Other Products]
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 UniProt Primary Accession #    P51800 [Other Products]
 UniProt Secondary Accession #    Q5T5P8; Q5T5Q4; Q7Z6D1; Q86VT1; B4DPD3; E7EPH6 [Other Products]
 UniProt Related Accession #    P51800 [Other Products]
 Molecular Weight    75,285 Da
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 NCBI Official Full Name    chloride channel protein ClC-Ka isoform 2
 NCBI Official Synonym Full Names    chloride channel, voltage-sensitive Ka
 NCBI Official Symbol    CLCNKA [Similar Products]
 NCBI Official Synonym Symbols   
CLCK1; ClC-K1; hClC-Ka
[Similar Products]
 NCBI Protein Information    chloride channel protein ClC-Ka; chloride channel Ka; chloride channel, kidney, A
 UniProt Protein Name    Chloride channel protein ClC-Ka
 UniProt Synonym Protein Names   
ClC-K1
 Protein Family    Chloride channel protein
 UniProt Gene Name    CLCNKA [Similar Products]
 UniProt Synonym Gene Names    Chloride channel Ka [Similar Products]
 UniProt Entry Name    CLCKA_HUMAN
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 NCBI Summary for CLCNKA    This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CLCNKA    CLCNKA: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Defects in CLCNKA are a cause of Bartter syndrome type 4B (BS4B). A digenic, recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4B is associated with sensorineural deafness. Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, ion channel

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: metal ion binding; voltage-gated chloride channel activity

Biological Process: transport; excretion; transmembrane transport

Disease: Bartter Syndrome, Type 4b
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 Research Articles on CLCNKA    1. The variant CLCNKA risk allele, telegraphed by linked variants in the adjacent HSPB7 gene, uncovers a previously overlooked genetic mechanism affecting the cardio-renal axis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CLCNKA antibodyDiseases associated with anti-CLCNKA antibody
 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >7 publications with CLCNKA and Hypertension
 Ear Diseases Antibodies  >4 publications with CLCNKA and Ear Diseases
 Bone Diseases Antibodies  >1 publications with CLCNKA and Bone Diseases
 Atrophy Antibodies  >1 publications with CLCNKA and Atrophy
 Liver Diseases Antibodies  >1 publications with CLCNKA and Liver Diseases
Organs/Tissues associated with anti-CLCNKA antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >57 publications with CLCNKA and Kidney
 Lung Antibodies  >1 publications with CLCNKA and Lung
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