NP_006630.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,541 Da
NCBI Official Full Name
cysteinyl leukotriene receptor 1
NCBI Official Synonym Full Names
cysteinyl leukotriene receptor 1
NCBI Official Synonym Symbols
HG55; CYSLT1; CYSLTR; CYSLT1R; HMTMF81 [Similar Products]
NCBI Protein Information
cysteinyl leukotriene receptor 1; LTD4 receptor; G-protein coupled receptor HG55; cysteinyl leukotriene D4 receptor
UniProt Protein Name
Cysteinyl leukotriene receptor 1
UniProt Synonym Protein Names
Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81
UniProt Synonym Gene Names
UniProt Entry Name
CLTR1_HUMAN
NCBI Summary for CLTR1
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. [provided by RefSeq, Jul 2008]
UniProt Comments for CLTR1
CYSLTR1: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: Xq13.2-q21.1
Cellular Component: membrane; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; leukotriene receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; calcium ion transport; positive regulation of vasoconstriction; defense response; respiratory gaseous exchange; inflammatory response; chemotaxis
Research Articles on CLTR1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-CLTR1 antibody
Diseases associated with anti-CLTR1 antibody
Organs/Tissues associated with anti-CLTR1 antibody
|