NP_005131.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
76,048 Da
NCBI Official Full Name
cyclic nucleotide-gated olfactory channel
NCBI Official Synonym Full Names
cyclic nucleotide gated channel alpha 2
NCBI Official Synonym Symbols
CNCA; CNG2; CNCA1; OCNC1; OCNCa; OCNCALPHA [Similar Products]
NCBI Protein Information
cyclic nucleotide-gated olfactory channel; CNG-2; CNG channel alpha-2; cyclic nucleotide-gated channel alpha-2; cyclic nucleotide-gated cation channel 2; cyclic-nucleotide-gated cation channel 2; cyclic-nucleotide-gated olfactory channel
UniProt Protein Name
Cyclic nucleotide-gated olfactory channel
UniProt Synonym Protein Names
Cyclic nucleotide-gated cation channel 2; Cyclic nucleotide-gated channel alpha-2
UniProt Synonym Gene Names
UniProt Entry Name
CNGA2_HUMAN
NCBI Summary for CNGA2
The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]
UniProt Comments for CNGA2
CNGA2: Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq27
Cellular Component: Golgi membrane; integral to plasma membrane
Molecular Function: calmodulin binding; voltage-gated potassium channel activity; intracellular cGMP activated cation channel activity; cGMP binding; cAMP binding
Biological Process: phototransduction, visible light; regulation of membrane potential; organelle organization and biogenesis; sensory perception of smell
Research Articles on CNGA2
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Diseases associated with anti-CNGA2 antibody
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