NP_001186231.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CCR4-NOT transcription complex subunit 2
NCBI Official Synonym Full Names
CCR4-NOT transcription complex, subunit 2
NCBI Protein Information
CCR4-NOT transcription complex subunit 2; CCR4-associated factor 2; negative regulator of transcription 2
UniProt Protein Name
CCR4-NOT transcription complex subunit 2
UniProt Synonym Protein Names
CCR4-associated factor 2
UniProt Synonym Gene Names
UniProt Entry Name
CNOT2_HUMAN
NCBI Summary for CNOT2
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for CNOT2
NOT2: The CCR4-NOT complex functions as general transcription regulation complex. Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Belongs to the CNOT2/3/5 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: membrane; cytoplasm; nucleus; cytosol; CCR4-NOT complex
Molecular Function: protein binding; poly(A)-specific ribonuclease activity
Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of translation; transcription from RNA polymerase II promoter; poly(A) tail shortening; gene expression; RNA-mediated gene silencing; negative regulation of transcription from RNA polymerase II promoter; negative regulation of estrogen receptor signaling pathway; mRNA catabolic process, deadenylation-dependent decay; trophectodermal cell differentiation
Research Articles on CNOT2
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Products associated with anti-CNOT2 antibody
Pathways associated with anti-CNOT2 antibody
Diseases associated with anti-CNOT2 antibody
Organs/Tissues associated with anti-CNOT2 antibody
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