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anti-CNR1 antibody :: CNR1 Antibody

Scan QR to view Datasheet Catalog #    MBS851303
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CNR1, Antibody

★Popular Item★
 Also Known As   

CNR1 Antibody

 Product Synonym Names    CANN6; cannabinoid receptor 1; CB-R; CB1; CB1R; CNR
 Product Gene Name   

anti-CNR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114610
 3D Structure    ModBase 3D Structure for P21554
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    CNR1 antibody detects endogenous levels of total CNR1 protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human CNR1.
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-CNR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CNR1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-CNR1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-CNR1 antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:1000
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 Testing Data of anti-CNR1 antibody    Peptide-+
anti-CNR1 antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-CNR1 antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using CNR1 antibody. Western blot analysis of extracts from COS-7cells and HT-29 cells, using CNR1 antibody.
anti-CNR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-CNR1 antibody    Peptide-+ Immunofluorescence analysis of LOVO cells, using CNR1 antibody.
anti-CNR1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CNR1. It may not necessarily be applicable to this product.
 NCBI GI #    237681067
 NCBI GeneID    1268
 NCBI Accession #    NP_001153698.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001160226.1 [Other Products]
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 UniProt Primary Accession #    P21554 [Other Products]
 UniProt Secondary Accession #    Q13949; Q495Z0; Q4PLI4; Q4VBM6; Q5JVL5; Q5UB37; Q9UNN0; B2R9T4; E1P512 [Other Products]
 UniProt Related Accession #    P21554 [Other Products]
 Molecular Weight    49,060 Da
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 NCBI Official Full Name    cannabinoid receptor 1 isoform a
 NCBI Official Synonym Full Names    cannabinoid receptor 1
 NCBI Official Symbol    CNR1 [Similar Products]
 NCBI Official Synonym Symbols   
CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
[Similar Products]
 NCBI Protein Information    cannabinoid receptor 1
 UniProt Protein Name    Cannabinoid receptor 1
 UniProt Synonym Protein Names   
CANN6
 Protein Family    Cannabinoid receptor
 UniProt Gene Name    CNR1 [Similar Products]
 UniProt Synonym Gene Names    CNR; CB-R; CB1 [Similar Products]
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 NCBI Summary for CNR1    This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
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 UniProt Comments for CNR1    G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta9-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca2+ channels in a constitutive, as well as agonist-dependent manner (PubMed:17895407). In cerebral vascular smooth muscle cells, cannabinoid-induced inhibition of voltage-gated Ca2+ channels leads to vasodilation and decreased vascular tone (). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes (). In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism (). In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (). In response to cannabinoid anandamide, elicits a proinflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (). In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712).
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Product References and Citations for anti-CNR1 antibody

   Gerard C., Nucleic Acids Res. 18:7142-7142(1990). Gerard C., Biochem. J. 279:129-134(1991). Shire D., J. Biol. Chem. 270:3726-3731(1995).
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 Research Articles on CNR1    1. This study of single-nucleotide polymorphisms in the cannabinoid receptor gene CNR1 showed that C carriers at rs806374 may be at specific risk for increased odds of cannabis use during the transition out of high school (around age 18).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CNR1 antibodyPathways associated with anti-CNR1 antibody
 Reference Product  PubMed Publications
 MET antibody  >8 publications with CNR1 and MET
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 N-cadherin Signaling Events Pathway antibodies  N-cadherin Signaling Events Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Retrograde Endocannabinoid Signaling Pathway antibodies  Retrograde Endocannabinoid Signaling Pathway Diagram
Diseases associated with anti-CNR1 antibodyOrgans/Tissues associated with anti-CNR1 antibody
 Disease Name  Pubmed Publications
 Substance-Related Disorders Antibodies  >48 publications with CNR1 and Substance-Related Disorders
 Obesity Antibodies  >44 publications with CNR1 and Obesity
 Nervous System Diseases Antibodies  >36 publications with CNR1 and Nervous System Diseases
 Schizophrenia Antibodies  >33 publications with CNR1 and Schizophrenia
 Disease Models, Animal Antibodies  >20 publications with CNR1 and Disease Models, Animal
 Brain Diseases Antibodies  >19 publications with CNR1 and Brain Diseases
 Marijuana Abuse Antibodies  >18 publications with CNR1 and Marijuana Abuse
 Pain Antibodies  >16 publications with CNR1 and Pain
 Weight Loss Antibodies  >14 publications with CNR1 and Weight Loss
 Weight Gain Antibodies  >11 publications with CNR1 and Weight Gain
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >95 publications with CNR1 and Brain
 Liver Antibodies  >13 publications with CNR1 and Liver
 Vascular Antibodies  >8 publications with CNR1 and Vascular
 Muscle Antibodies  >6 publications with CNR1 and Muscle
 Testis Antibodies  >4 publications with CNR1 and Testis
 Pancreas Antibodies  >4 publications with CNR1 and Pancreas
 Uterus Antibodies  >3 publications with CNR1 and Uterus
 Placenta Antibodies  >3 publications with CNR1 and Placenta
 Eye Antibodies  >3 publications with CNR1 and Eye
 Lung Antibodies  >2 publications with CNR1 and Lung
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