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anti-CNR1 antibody :: Rabbit CNR1 Antibody

Scan QR to view Datasheet Catalog #    MBS851303
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CNR1, Antibody

★Popular Item★
 Also Known As   

CNR1 Antibody

 Product Synonym Names    CANN6; cannabinoid receptor 1; CB-R; CB1; CB1R; CNR
 Product Gene Name   

anti-CNR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114610
 3D Structure    ModBase 3D Structure for P21554
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    CNR1 antibody detects endogenous levels of total CNR1 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human CNR1.
 Pathway    GPCR
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-CNR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CNR1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-CNR1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-CNR1 antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:1000
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 Testing Data of anti-CNR1 antibody    anti-CNR1 antibody Testing Data image
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 Testing Data #2 of anti-CNR1 antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using CNR1 antibody.
Western blot analysis of extracts from COS-7cells and HT-29 cells, using CNR1 antibody.
anti-CNR1 antibody Testing Data #2 image
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 Testing Data #3 of anti-CNR1 antibody    Peptide - +
Immunofluorescence analysis of LOVO cells, using CNR1 antibody.
anti-CNR1 antibody Testing Data #3 image
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NCBI/Uniprot data below describe general gene information for CNR1. It may not necessarily be applicable to this product.
 NCBI GI #    237681067
 NCBI GeneID    1268
 NCBI Accession #    NP_001153698.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001160226.1 [Other Products]
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 UniProt Primary Accession #    P21554 [Other Products]
 UniProt Secondary Accession #    Q13949; Q495Z0; Q4PLI4; Q4VBM6; Q5JVL5; Q5UB37; Q9UNN0; B2R9T4; E1P512 [Other Products]
 UniProt Related Accession #    P21554 [Other Products]
 Molecular Weight    49,060 Da
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 NCBI Official Full Name    cannabinoid receptor 1 isoform a
 NCBI Official Synonym Full Names    cannabinoid receptor 1 (brain)
 NCBI Official Symbol    CNR1 [Similar Products]
 NCBI Official Synonym Symbols   
CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
[Similar Products]
 NCBI Protein Information    cannabinoid receptor 1; central cannabinoid receptor
 UniProt Protein Name    Cannabinoid receptor 1
 UniProt Synonym Protein Names   
CANN6
 Protein Family    Cannabinoid receptor
 UniProt Gene Name    CNR1 [Similar Products]
 UniProt Synonym Gene Names    CNR; CB-R; CB1 [Similar Products]
 UniProt Entry Name    CNR1_HUMAN
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 NCBI Summary for CNR1    This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
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 UniProt Comments for CNR1    CNR1: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 6q14-q15

Cellular Component: growth cone; intracellular membrane-bound organelle; integral to plasma membrane; axon; plasma membrane

Molecular Function: cannabinoid receptor activity; drug binding

Biological Process: response to nicotine; maternal process involved in pregnancy; regulation of synaptic transmission, glutamatergic; negative regulation of fatty acid beta-oxidation; positive regulation of apoptosis; response to morphine; positive regulation of acute inflammatory response to antigenic stimulus; response to lipopolysaccharide; sensory perception of pain; glucose homeostasis; negative regulation of blood pressure; negative regulation of dopamine secretion; response to nutrient; aging; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; axonal fasciculation; negative regulation of action potential; response to cocaine; memory; regulation of synaptic transmission, GABAergic; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; response to ethanol; positive regulation of fever; spermatogenesis; regulation of insulin secretion; positive regulation of blood pressure
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Product References and Citations for anti-CNR1 antibody

   Gerard C., Nucleic Acids Res. 18:7142-7142(1990).
Gerard C., Biochem. J. 279:129-134(1991).
Shire D., J. Biol. Chem. 270:3726-3731(1995).
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 Research Articles on CNR1    1. The mRNA level for cannabinoid receptor type 1 (CB1) was no different in peripheral blood mononuclear cells from autistic children as compared to healthy subjects
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CNR1 antibodyDiseases associated with anti-CNR1 antibody
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 N-cadherin Signaling Events Pathway antibodies  N-cadherin Signaling Events Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Obesity Antibodies  >58 publications with CNR1 and Obesity
 Substance-Related Disorders Antibodies  >54 publications with CNR1 and Substance-Related Disorders
 Nervous System Diseases Antibodies  >45 publications with CNR1 and Nervous System Diseases
 Schizophrenia Antibodies  >38 publications with CNR1 and Schizophrenia
 Disease Models, Animal Antibodies  >28 publications with CNR1 and Disease Models, Animal
 Brain Diseases Antibodies  >24 publications with CNR1 and Brain Diseases
 Pain Antibodies  >23 publications with CNR1 and Pain
 Marijuana Abuse Antibodies  >20 publications with CNR1 and Marijuana Abuse
 Weight Loss Antibodies  >18 publications with CNR1 and Weight Loss
 Weight Gain Antibodies  >17 publications with CNR1 and Weight Gain
Organs/Tissues associated with anti-CNR1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >141 publications with CNR1 and Brain
 Liver Antibodies  >21 publications with CNR1 and Liver
 Vascular Antibodies  >10 publications with CNR1 and Vascular
 Muscle Antibodies  >10 publications with CNR1 and Muscle
 Eye Antibodies  >8 publications with CNR1 and Eye
 Pancreas Antibodies  >6 publications with CNR1 and Pancreas
 Testis Antibodies  >4 publications with CNR1 and Testis
 Uterus Antibodies  >3 publications with CNR1 and Uterus
 Placenta Antibodies  >3 publications with CNR1 and Placenta
 Lung Antibodies  >3 publications with CNR1 and Lung
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