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anti-COPS2 antibody :: Rabbit COPS2 Antibody

Scan QR to view Datasheet Catalog #    MBS003034 anti-COPS2 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

COPS2, Antibody

 Also Known As   

Rabbit COPS2 Antibody

 Product Gene Name   

anti-COPS2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 15; NC_000015.9 (49417471..49447854, complement). Location: 15q21.2
 OMIM    604508
 3D Structure    ModBase 3D Structure for P61201
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-COPS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-COPS2 antibody   

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for COPS2. It may not necessarily be applicable to this product.
 NCBI GI #    219842262
 NCBI GeneID    9318
 NCBI Accession #    NP_001137359.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001143887.1 [Other Products]
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 UniProt Primary Accession #    P61201 [Other Products]
 UniProt Secondary Accession #    O88950; Q15647; Q6FGP4; Q9BY54; Q9R249; Q9UNI2; Q9UNQ5 [Other Products]
 UniProt Related Accession #    P61201 [Other Products]
 Molecular Weight    51,597 Da
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 NCBI Official Full Name    COP9 signalosome complex subunit 2 isoform 2
 NCBI Official Synonym Full Names    COP9 signalosome subunit 2
 NCBI Official Symbol    COPS2 [Similar Products]
 NCBI Official Synonym Symbols   
CSN2; SGN2; ALIEN; TRIP15
[Similar Products]
 NCBI Protein Information    COP9 signalosome complex subunit 2; TRIP-15; alien homolog; signalosome subunit 2; TR-interacting protein 15; JAB1-containing signalosome subunit 2; thyroid receptor interacting protein 15; thyroid receptor-interacting protein 15; COP9 constitutive photomorphogenic homolog subunit 2
 UniProt Protein Name    COP9 signalosome complex subunit 2
 UniProt Synonym Protein Names   
Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15
 UniProt Gene Name    COPS2 [Similar Products]
 UniProt Synonym Gene Names    CSN2; TRIP15; SGN2; Signalosome subunit 2; TR-interacting protein 15; TRIP-15 [Similar Products]
 UniProt Entry Name    CSN2_HUMAN
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 UniProt Comments for COPS2    COPS2: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Belongs to the CSN2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: signalosome; cytoplasm

Molecular Function: protein binding; signal transducer activity; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; neuron differentiation; cell proliferation; cullin deneddylation; negative regulation of transcription from RNA polymerase II promoter; signal transduction
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 Research Articles on COPS2    1. p300 binds to Alien alpha by pull down (View interaction) Alien alpha physically interacts with CBP by two hybrid
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-COPS2 antibodyDiseases associated with anti-COPS2 antibody
 Reference Product  PubMed Publications
 COPS5 antibody  >3 publications with COPS2 and COPS5
 NR0B1 antibody  >2 publications with COPS2 and NR0B1
 NIF3L1 antibody  >1 publications with COPS2 and NIF3L1
 GPS1 antibody  >1 publications with COPS2 and GPS1
 COPS6 antibody  >1 publications with COPS2 and COPS6
 COPS4 antibody  >1 publications with COPS2 and COPS4
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with COPS2 and Neoplasms
 Prostatic Neoplasms Antibodies  >1 publications with COPS2 and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >1 publications with COPS2 and Prostatic Diseases
Organs/Tissues associated with anti-COPS2 antibody
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >14 publications with COPS2 and Thyroid
 Brain Antibodies  >3 publications with COPS2 and Brain
 Blood Antibodies  >2 publications with COPS2 and Blood
 Embryonic Tissue Antibodies  >2 publications with COPS2 and Embryonic Tissue
 Adrenal Gland Antibodies  >1 publications with COPS2 and Adrenal Gland
 Intestine Antibodies  >1 publications with COPS2 and Intestine
 Muscle Antibodies  >1 publications with COPS2 and Muscle
 Liver Antibodies  >1 publications with COPS2 and Liver
 Testis Antibodies  >1 publications with COPS2 and Testis
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