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anti-CRMP-2 antibody :: CRMP-2 Antibody

Scan QR to view Datasheet Catalog #    MBS854616
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CRMP-2, Antibody

★Popular Item★
 Also Known As   

CRMP-2 (Phospho-Thr509) Antibody

 Product Synonym Names    Collapsin response mediator protein 2; CRMP2; Dihydropyrimidinase related protein-2; DPYL2; DPYSL2; DRP-2; N2A3; TOAD-64; Turned on after division; 64 kDa protein; ULIP 2 protein; ULIP2
 Product Gene Name   

anti-CRMP-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602463
 3D Structure    ModBase 3D Structure for Q16555
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    CRMP-2 (Phospho-Thr509) antibody detects endogenous levels of CRMP-2 only when phosphorylated at threonine 509.
 Purity/Purification    Affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human CRMP-2 around the phosphorylation site of threonine 509 (S-V-TP-PK).
 All Sites    Human: Thr509
Mouse: Thr509
Rat: Thr509
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-CRMP-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CRMP-2 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-CRMP-2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-CRMP-2 antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:1000
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 Testing Data of anti-CRMP-2 antibody    P-peptide-+
anti-CRMP-2 antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-CRMP-2 antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using CRMP-2 (Phospho-Thr509) antibody. Western blot analysis of extracts from HT-29 cells, treated with heat shock, using CRMP-2 (Phospho-Thr509) antibody.
anti-CRMP-2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CRMP-2. It may not necessarily be applicable to this product.
 NCBI GI #    308818195
 NCBI GeneID    1808
 NCBI Accession #    NP_001184222.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001197293.2 [Other Products]
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 UniProt Primary Accession #    Q16555 [Other Products]
 UniProt Secondary Accession #    O00424; A8K5H2; B4DR31; D3DSS7 [Other Products]
 UniProt Related Accession #    Q16555 [Other Products]
 Molecular Weight    58,163 Da
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 NCBI Official Full Name    dihydropyrimidinase-related protein 2 isoform 1
 NCBI Official Synonym Full Names    dihydropyrimidinase like 2
 NCBI Official Symbol    DPYSL2 [Similar Products]
 NCBI Official Synonym Symbols   
DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2
[Similar Products]
 NCBI Protein Information    dihydropyrimidinase-related protein 2
 UniProt Protein Name    Dihydropyrimidinase-related protein 2
 UniProt Synonym Protein Names   
Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2
 UniProt Gene Name    DPYSL2 [Similar Products]
 UniProt Synonym Gene Names    CRMP2; ULIP2; DRP-2; CRMP-2; ULIP-2 [Similar Products]
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 NCBI Summary for CRMP-2    This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for CRMP-2    Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
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Product References and Citations for anti-CRMP-2 antibody

   Miki Y., Science 266:66-71(1994). Smith T.M., Genome Res. 6:1029-1049(1996). Wilson C.A., Oncogene 14:1-16(1997).
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 Research Articles on CRMP-2    1. cross-talk between distinct CRMP2 posttranslational modifications is a key factor in determining NaV1.7 trafficking and localization
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRMP-2 antibodyPathways associated with anti-CRMP-2 antibody
 Reference Product  PubMed Publications
 GSK3B antibody  >1 publications with CRMP-2 and GSK3B
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CRMPs In Sema3A Signaling Pathway antibodies  CRMPs In Sema3A Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 Recycling Pathway Of L1 antibodies  Recycling Pathway Of L1 Diagram
 Regulation Of Microtubule Cytoskeleton Pathway antibodies  Regulation Of Microtubule Cytoskeleton Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram
Diseases associated with anti-CRMP-2 antibodyOrgans/Tissues associated with anti-CRMP-2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with CRMP-2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >2 publications with CRMP-2 and Disease Models, Animal
 Schizophrenia, Paranoid Antibodies  >2 publications with CRMP-2 and Schizophrenia, Paranoid
 Nerve Degeneration Antibodies  >1 publications with CRMP-2 and Nerve Degeneration
 Poisoning Antibodies  >1 publications with CRMP-2 and Poisoning
 Neurobehavioral Manifestations Antibodies  >1 publications with CRMP-2 and Neurobehavioral Manifestations
 Inflammation Antibodies  >1 publications with CRMP-2 and Inflammation
 Alzheimer Disease Antibodies  >1 publications with CRMP-2 and Alzheimer Disease
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >13 publications with CRMP-2 and Nerve
 Brain Antibodies  >11 publications with CRMP-2 and Brain
 Embryonic Tissue Antibodies  >2 publications with CRMP-2 and Embryonic Tissue
 Ganglia Antibodies  >1 publications with CRMP-2 and Ganglia
 Bone Antibodies  >1 publications with CRMP-2 and Bone
 Spinal Cord Antibodies  >1 publications with CRMP-2 and Spinal Cord
 Eye Antibodies  >1 publications with CRMP-2 and Eye
 Muscle Antibodies  >1 publications with CRMP-2 and Muscle
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