NP_000092.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,013 Da
NCBI Official Full Name
cytochrome b-245 light chain
NCBI Official Synonym Full Names
cytochrome b-245 alpha chain
NCBI Official Synonym Symbols
NCBI Protein Information
cytochrome b-245 light chain
UniProt Protein Name
Cytochrome b-245 light chain
UniProt Synonym Protein Names
Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phox
UniProt Synonym Gene Names
NCBI Summary for CYBA
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]
UniProt Comments for CYBA
CYBA: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. Belongs to the p22phox family.
Protein type: EC 1.-.-.-; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: 16q24.2
Cellular Component: endoplasmic reticulum membrane; membrane; NADPH oxidase complex; phagocytic vesicle membrane; plasma membrane; secretory granule
Molecular Function: electron carrier activity; protein binding; protein heterodimerization activity; SH3 domain binding; superoxide-generating NADPH oxidase activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; cytochrome complex assembly; hydrogen peroxide biosynthetic process; inflammatory response; innate immune response; positive regulation of interleukin-6 production; positive regulation of phagocytosis; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of tumor necrosis factor production; respiratory burst; response to reactive oxygen species; smooth muscle hypertrophy; superoxide metabolic process; superoxide release; vascular endothelial growth factor receptor signaling pathway
Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-negative
Research Articles on CYBA
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Products associated with anti-CYBA antibody
Pathways associated with anti-CYBA antibody
Diseases associated with anti-CYBA antibody
Organs/Tissues associated with anti-CYBA antibody
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