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anti-COL1A2 antibody :: Rabbit Collagen I Antibody

Scan QR to view Datasheet Catalog #    MBS003247 anti-COL1A2 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen I (COL1A2), Antibody

 Also Known As   

Rabbit Collagen I Antibody

 Product Gene Name   

anti-COL1A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (94023873..94060544). Location: 7q22.1
 OMIM    120160
 3D Structure    ModBase 3D Structure for P08123
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-COL1A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-COL1A2 antibody   

Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for COL1A2. It may not necessarily be applicable to this product.
 NCBI GI #    48762934
 NCBI GeneID    1278
 NCBI Accession #    NP_000080.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000089.3 [Other Products]
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 UniProt Primary Accession #    P08123 [Other Products]
 UniProt Secondary Accession #    P02464; Q13897; Q13997; Q13998; Q14038; Q14057; Q15177; Q15947; Q16480; Q16511; Q7Z5S6 [Other Products]
 UniProt Related Accession #    P08123 [Other Products]
 Molecular Weight    129,314 Da [Similar Products]
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 NCBI Official Full Name    collagen alpha-2(I) chain
 NCBI Official Synonym Full Names    collagen, type I, alpha 2
 NCBI Official Symbol    COL1A2 [Similar Products]
 NCBI Official Synonym Symbols   
OI4
[Similar Products]
 NCBI Protein Information    collagen alpha-2(I) chain; collagen alpha-2(I) chain; type I procollagen; alpha 2(I)-collagen; alpha-2 type I collagen; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-2 chain
 UniProt Protein Name    Collagen alpha-2(I) chain
 UniProt Synonym Protein Names   
Alpha-2 type I collagen
 Protein Family    Collagen
 UniProt Gene Name    COL1A2 [Similar Products]
 UniProt Entry Name    CO1A2_HUMAN
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 NCBI Summary for COL1A2    This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
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 UniProt Comments for COL1A2    COL1A2: Type I collagen is a member of group I collagen (fibrillar forming collagen). Defects in COL1A2 are the cause of Ehlers-Danlos syndrome type 7B (EDS7B). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7B is marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations. Defects in COL1A2 are a cause of osteogenesis imperfecta type 1 (OI1). A dominantly inherited connective tissue disorder characterized by bone fragility and blue sclerae. Osteogenesis imperfecta type 1 is non-deforming with normal height or mild short stature, and no dentinogenesis imperfecta. Defects in COL1A2 are a cause of osteogenesis imperfecta type 2 (OI2); also known as osteogenesis imperfecta congenita (OIC) or lethal perinatal. A connective tissue disorder characterized by bone fragility, with many perinatal fractures, severe bowing of long bones, undermineralization, and death in the perinatal period due to respiratory insufficiency. Defects in COL1A2 are the cause of Ehlers-Danlos syndrome autosomal recessive cardiac valvular form (EDSCV). A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. In addition to joint laxity, skin hyperextensibility and friability, and abnormal scar formation, patients have mitral valve prolapse and insufficiency, mitral regurgitation, and aortic insufficiency. Defects in COL1A2 are a cause of osteogenesis imperfecta type 3 (OI3). A connective tissue disorder characterized by progressively deforming bones, very short stature, a triangular face, severe scoliosis, grayish sclera, and dentinogenesis imperfecta. Defects in COL1A2 are a cause of osteogenesis imperfecta type 4 (OI4); also known as osteogenesis imperfecta with normal sclerae. A connective tissue disorder characterized by moderately short stature, mild to moderate scoliosis, grayish or white sclera and dentinogenesis imperfecta. A chromosomal aberration involving COL1A2 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. Translocation t(7;8)(p22;q13) with PLAG1. Belongs to the fibrillar collagen family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: extracellular matrix; extracellular space; endoplasmic reticulum lumen; extracellular region; collagen type I

Molecular Function: protein binding, bridging; identical protein binding; protein binding; metal ion binding; extracellular matrix structural constituent; platelet-derived growth factor binding; SMAD binding

Biological Process: platelet activation; blood vessel development; receptor-mediated endocytosis; extracellular matrix organization and biogenesis; collagen fibril organization; skin morphogenesis; Rho protein signal transduction; odontogenesis; extracellular matrix disassembly; collagen catabolic process; transforming growth factor beta receptor signaling pathway; regulation of blood pressure; blood coagulation; leukocyte migration; skeletal development

Disease: Ehlers-danlos Syndrome, Type Vii, Autosomal Dominant; Osteogenesis Imperfecta, Type Ii; Ehlers-danlos Syndrome, Autosomal Recessive, Cardiac Valvular Form; Osteogenesis Imperfecta, Type Iii; Osteoporosis; Osteogenesis Imperfecta, Type Iv
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 Research Articles on COL1A2    1. A spontaneous novel mutation in COL1A2 (c.1171G>A; p.Gly391Ser) causing only dentin defects and a novel mutation in PAX9 (c.43T>A; p.Phe15Ile) causing hypodontia were identified and correlated with the phenotypic presentations in the family.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-COL1A2 antibodyPathways associated with anti-COL1A2 antibody
 Reference Product  PubMed Publications
 SPARC antibody  >28 publications with COL1A2 and SPARC
 FN1 antibody  >10 publications with COL1A2 and FN1
 LUM antibody  >5 publications with COL1A2 and LUM
 TGFBI antibody  >4 publications with COL1A2 and TGFBI
 MMP9 antibody  >4 publications with COL1A2 and MMP9
 DCN antibody  >4 publications with COL1A2 and DCN
 BGN antibody  >3 publications with COL1A2 and BGN
 VWF antibody  >2 publications with COL1A2 and VWF
 COL5A3 antibody  >1 publications with COL1A2 and COL5A3
 CD44 antibody  >1 publications with COL1A2 and CD44
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with anti-COL1A2 antibodyOrgans/Tissues associated with anti-COL1A2 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >156 publications with COL1A2 and Fibrosis
 Cardiovascular Diseases Antibodies  >81 publications with COL1A2 and Cardiovascular Diseases
 Neoplasms Antibodies  >65 publications with COL1A2 and Neoplasms
 Liver Diseases Antibodies  >39 publications with COL1A2 and Liver Diseases
 Osteoporosis Antibodies  >32 publications with COL1A2 and Osteoporosis
 Heart Diseases Antibodies  >30 publications with COL1A2 and Heart Diseases
 Necrosis Antibodies  >29 publications with COL1A2 and Necrosis
 Liver Cirrhosis Antibodies  >28 publications with COL1A2 and Liver Cirrhosis
 Inflammation Antibodies  >28 publications with COL1A2 and Inflammation
 Brain Diseases Antibodies  >22 publications with COL1A2 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >242 publications with COL1A2 and Bone
 Connective Tissue Antibodies  >176 publications with COL1A2 and Connective Tissue
 Skin Antibodies  >170 publications with COL1A2 and Skin
 Muscle Antibodies  >67 publications with COL1A2 and Muscle
 Blood Antibodies  >65 publications with COL1A2 and Blood
 Liver Antibodies  >65 publications with COL1A2 and Liver
 Embryonic Tissue Antibodies  >45 publications with COL1A2 and Embryonic Tissue
 Vascular Antibodies  >41 publications with COL1A2 and Vascular
 Lung Antibodies  >37 publications with COL1A2 and Lung
 Heart Antibodies  >35 publications with COL1A2 and Heart
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