Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow COL6A3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • CDK7 (Phospho-Thr170) Antibody
 • VEGFR1 (Phospho-Tyr1213) Antibody
 • SGK269 Antibody
 • Immunoglobulin M (IgM) ELISA Kit
 • Chemokine Like Factor Superfamily 4 (CKLFSF4) ELISA Kit
 • Podocalyxin (PCX) ELISA Kit
 • Aquaporin 1 (AQP-1) ELISA Kit
 • Dynorphin ELISA Kit
 • Pancreatic Carcinoma Marker-Ca242 ELISA Kit
 • Interferon gamma (IFN-gamma) ELISA Kit
 • Glycogen Synthase Kinase 3 (GSK-3) ELISA Kit
 • Myelin Associated Glycoprotein Antibody (MAG) ELISA Kit
 • Tar DNA Binding Protein 43 (TDP43) ELISA Kit
 • Beta 1 Adrenergic Receptor Antibodies (B1AR) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-COL6A3 antibody :: Rabbit anti-Human, mouse Collagen VI alpha3 Antibody

Scan QR to view Datasheet Catalog #    MBS001579 anti-COL6A3 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen VI alpha3 (COL6A3), Antibody

 Also Known As   

Rabbit Collagen VI alpha3 Antibody

 Product Synonym Names    Collagen VI a3
 Product Gene Name   

anti-COL6A3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 2; NC_000002.11 (238232655..238322850, complement). Location: 2q37
 OMIM    120250
 3D Structure    ModBase 3D Structure for P12111
Section Bar
 Host    Rabbit
 Species Reactivity    Human, mouse
Section Bar
 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
Section Bar
Section Bar
 Other Notes    Small volumes of anti-COL6A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-COL6A3 antibody   

Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA (EIA)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for COL6A3. It may not necessarily be applicable to this product.
 NCBI GI #    55743098
 NCBI GeneID    1293
 NCBI Accession #    NP_004360.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004369.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P12111 [Other Products]
 UniProt Secondary Accession #    Q16501; Q53QF4; Q53QF6; A8MT30; B7ZMJ7; E9PFQ6 [Other Products]
 UniProt Related Accession #    P12111 [Other Products]
 Molecular Weight    343,669 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    collagen alpha-3(VI) chain isoform 1
 NCBI Official Synonym Full Names    collagen, type VI, alpha 3
 NCBI Official Symbol    COL6A3 [Similar Products]
 NCBI Protein Information    collagen alpha-3(VI) chain; collagen alpha-3(VI) chain; collagen VI, alpha-3 polypeptide
 UniProt Protein Name    Collagen alpha-3(VI) chain
 Protein Family    Collagen
 UniProt Gene Name    COL6A3 [Similar Products]
 UniProt Entry Name    CO6A3_HUMAN
Section Bar
 NCBI Summary for COL6A3    This gene encodes the alpha-3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The alpha-3 chain of type VI collagen is much larger than the alpha-1 and -2 chains. This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, that are found in the amino terminal globular domain of all the alpha chains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in the type VI collagen genes are associated with Bethlem myopathy, a rare autosomal dominant proximal myopathy with early childhood onset. Mutations in this gene are also a cause of Ullrich congenital muscular dystrophy, also referred to as Ullrich scleroatonic muscular dystrophy, an autosomal recessive congenital myopathy that is more severe than Bethlem myopathy. Multiple transcript variants have been identified, but the full-length nature of only some of these variants has been described. [provided by RefSeq, Jun 2009]
Section Bar
 UniProt Comments for COL6A3    COL6A3: Collagen VI acts as a cell-binding protein. Defects in COL6A3 are a cause of Bethlem myopathy (BM). BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles. Defects in COL6A3 are a cause of Ullrich congenital muscular dystrophy (UCMD); also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy. Belongs to the type VI collagen family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Extracellular matrix

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum lumen; extracellular region; collagen type VI; vesicle; sarcolemma

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: axon guidance; extracellular matrix disassembly; collagen catabolic process; muscle development; extracellular matrix organization and biogenesis; cell adhesion

Disease: Bethlem Myopathy; Ullrich Congenital Muscular Dystrophy; Dystonia 27
Table BarTOPTable Bar
 Research Articles on COL6A3    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-COL6A3 antibodyPathways associated with anti-COL6A3 antibody
 Reference Product  PubMed Publications
 MMP2 antibody  >1 publications with COL6A3 and MMP2
 Products by Pathway  Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with anti-COL6A3 antibodyOrgans/Tissues associated with anti-COL6A3 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >39 publications with COL6A3 and Nervous System Diseases
 Bethlem myopathy Antibodies  >28 publications with COL6A3 and Bethlem myopathy
 Neoplasms Antibodies  >17 publications with COL6A3 and Neoplasms
 Inflammation Antibodies  >4 publications with COL6A3 and Inflammation
 Fibrosis Antibodies  >4 publications with COL6A3 and Fibrosis
 Scleroatonic muscular dystrophy Antibodies  >4 publications with COL6A3 and Scleroatonic muscular dystrophy
 Brain Diseases Antibodies  >3 publications with COL6A3 and Brain Diseases
 Adenocarcinoma Antibodies  >3 publications with COL6A3 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >3 publications with COL6A3 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >2 publications with COL6A3 and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >29 publications with COL6A3 and Muscle
 Skin Antibodies  >19 publications with COL6A3 and Skin
 Connective Tissue Antibodies  >9 publications with COL6A3 and Connective Tissue
 Lung Antibodies  >4 publications with COL6A3 and Lung
 Adipose Tissue Antibodies  >4 publications with COL6A3 and Adipose Tissue
 Brain Antibodies  >4 publications with COL6A3 and Brain
 Placenta Antibodies  >2 publications with COL6A3 and Placenta
 Vascular Antibodies  >2 publications with COL6A3 and Vascular
 Liver Antibodies  >2 publications with COL6A3 and Liver
 Embryonic Tissue Antibodies  >2 publications with COL6A3 and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions