NP_001013417.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cyclin-C isoform b
NCBI Official Synonym Full Names
cyclin C
NCBI Official Synonym Symbols
NCBI Protein Information
cyclin-C; hSRB11; SRB11 homolog
UniProt Protein Name
Cyclin-C
UniProt Synonym Protein Names
SRB11 homolog
UniProt Synonym Gene Names
UniProt Entry Name
CCNC_HUMAN
NCBI Summary for CCNC
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CCNC
CCNC: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Belongs to the cyclin family. Cyclin C subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: nucleoplasm; Srb-mediator complex; DNA-directed RNA polymerase II, holoenzyme
Molecular Function: protein binding; protein kinase binding
Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of cyclin-dependent protein kinase activity
Research Articles on CCNC
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Products associated with anti-CCNC antibody
Pathways associated with anti-CCNC antibody
Diseases associated with anti-CCNC antibody
Organs/Tissues associated with anti-CCNC antibody
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