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anti-CYP17A1 antibody :: Rabbit anti-Human Cytochrome P450 17A1 Antibody

Scan QR to view Datasheet Catalog #    MBS000945 anti-CYP17A1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytochrome P450 17A1 (CYP17A1), Antibody

 Also Known As   

Rabbit Cytochrome P450 17A1 Antibody

 Product Gene Name   

anti-CYP17A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (104590288..104597290, complement). Location: 10q24.3
 OMIM    202110
 3D Structure    ModBase 3D Structure for P05093
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 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-CYP17A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CYP17A1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CYP17A1. It may not necessarily be applicable to this product.
 NCBI GI #    4503195
 NCBI GeneID    1586
 NCBI Accession #    NP_000093.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000102.3 [Other Products]
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 UniProt Primary Accession #    P05093 [Other Products]
 UniProt Secondary Accession #    Q5TZV7 [Other Products]
 UniProt Related Accession #    P05093 [Other Products]
 Molecular Weight    57,371 Da [Similar Products]
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 NCBI Official Full Name    steroid 17-alpha-hydroxylase/17,20 lyase
 NCBI Official Synonym Full Names    cytochrome P450, family 17, subfamily A, polypeptide 1
 NCBI Official Symbol    CYP17A1 [Similar Products]
 NCBI Official Synonym Symbols   
CPT7; CYP17; S17AH; P450C17
[Similar Products]
 NCBI Protein Information    steroid 17-alpha-hydroxylase/17,20 lyase; CYPXVII; cytochrome P450c17; cytochrome P450-C17; cytochrome P450 17A1; cytochrome p450 XVIIA1; steroid 17-alpha-monooxygenase; 17-alpha-hydroxyprogesterone aldolase; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia
 UniProt Protein Name    Steroid 17-alpha-hydroxylase/17,20 lyase
 UniProt Synonym Protein Names   
17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase
 Protein Family    Steroid 17-alpha-hydroxylase/17,20 lyase
 UniProt Gene Name    CYP17A1 [Similar Products]
 UniProt Synonym Gene Names    CYP17; S17AH; Cytochrome P450c17 [Similar Products]
 UniProt Entry Name    CP17A_HUMAN
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 NCBI Summary for CYP17A1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP17A1    CYP17A1: Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5). AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: salt wasting (SW, the most severe type), simple virilizing (SV, less severely affected patients), with normal aldosterone biosynthesis, non-classic form or late onset (NC or LOAH), and cryptic (asymptomatic). Belongs to the cytochrome P450 family.

Protein type: EC 4.1.2.30; EC 1.14.99.9; Oxidoreductase; Lipid Metabolism - C21-steroid hormone

Chromosomal Location of Human Ortholog: 10q24.3

Cellular Component: endoplasmic reticulum membrane; cell soma; mitochondrion; endoplasmic reticulum; axon

Molecular Function: 17-alpha-hydroxyprogesterone aldolase activity; steroid 17-alpha-monooxygenase activity; iron ion binding; heme binding; oxygen binding

Biological Process: steroid metabolic process; response to cAMP; dibenzo-p-dioxin metabolic process; androgen biosynthetic process; progesterone metabolic process; response to insecticide; Leydig cell differentiation; biphenyl metabolic process; response to methylmercury; hormone biosynthetic process; response to drug; response to nutrient levels; response to retinoic acid; adrenal gland development; phthalate metabolic process; hippocampus development; response to herbicide; ovulation; response to acetate; response to steroid hormone stimulus; xenobiotic metabolic process; response to cytokine stimulus; response to ionizing radiation; glucocorticoid biosynthetic process; sex differentiation; sterol metabolic process; steroid biosynthetic process; phenol metabolic process

Disease: Adrenal Hyperplasia, Congenital, Due To 17-alpha-hydroxylase Deficiency
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 Research Articles on CYP17A1    1. Meta-analysis indicated significant associations of both CYP17A1 rs11191548 and FGF5 rs16998073 polymorphisms with hypertension susceptibility in East Asians.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Rabbit Cytochrome P450 17A1 Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS9400196  Cytochrome P450 17A1 Monoclonal Antibody  MBS820246  Anti-Cytochrome P450 17A1 Antibody
 MBS000945  Rabbit Cytochrome P450 17A1 Antibody  MBS851266  Cytochrome P450 17A1 Antibody
 MBS9216745  Rabbit Anti-Cytochrome P450 17A1 Polyclonal Antibody  MBS475082  Cytochrome P450 17A1
 MBS8502369  Cytochrome P450 17A1 Antibody  MBS9215368  Cytochrome P450 17A1 Antibody
 MBS9305673  Bovine Steroid 17-alpha-hydroxylase/17, 20 lyase;Cytochrome P450 17A1, CYP17A1 ELISA Kit  MBS824076  Cytochrome P450 17A1 Blocking Peptide
Products associated with anti-CYP17A1 antibodyPathways associated with anti-CYP17A1 antibody
 Reference Product  PubMed Publications
 POR antibody  >26 publications with CYP17A1 and POR
 CYB5A antibody  >5 publications with CYP17A1 and CYB5A
 Products by Pathway  Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 Glucocorticoid & Mineralcorticoid Metabolism Pathway antibodies  Glucocorticoid & Mineralcorticoid Metabolism Pathway Diagram
 Glucocorticoid Biosynthesis Pathway antibodies  Glucocorticoid Biosynthesis Pathway Diagram
Diseases associated with anti-CYP17A1 antibodyOrgans/Tissues associated with anti-CYP17A1 antibody
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >310 publications with CYP17A1 and Hyperplasia
 Disorders of Sex Development Antibodies  >302 publications with CYP17A1 and Disorders of Sex Development
 Genital Diseases, Male Antibodies  >243 publications with CYP17A1 and Genital Diseases, Male
 Prostatic Neoplasms Antibodies  >190 publications with CYP17A1 and Prostatic Neoplasms
 Hypertension Antibodies  >161 publications with CYP17A1 and Hypertension
 Breast Neoplasms Antibodies  >109 publications with CYP17A1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >86 publications with CYP17A1 and Cardiovascular Diseases
 Drug Toxicity Antibodies  >77 publications with CYP17A1 and Drug Toxicity
 Adenocarcinoma Antibodies  >39 publications with CYP17A1 and Adenocarcinoma
 Testicular Diseases Antibodies  >38 publications with CYP17A1 and Testicular Diseases
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >562 publications with CYP17A1 and Testis
 Adrenal Gland Antibodies  >524 publications with CYP17A1 and Adrenal Gland
 Ovary Antibodies  >487 publications with CYP17A1 and Ovary
 Brain Antibodies  >111 publications with CYP17A1 and Brain
 Kidney Antibodies  >58 publications with CYP17A1 and Kidney
 Embryonic Tissue Antibodies  >57 publications with CYP17A1 and Embryonic Tissue
 Muscle Antibodies  >26 publications with CYP17A1 and Muscle
 Thyroid Antibodies  >11 publications with CYP17A1 and Thyroid
 Mammary Gland Antibodies  >2 publications with CYP17A1 and Mammary Gland
 Bladder Antibodies  >2 publications with CYP17A1 and Bladder
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