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anti-CYP19A1 antibody :: Rabbit Cytochrome P450 19A1 Antibody

Scan QR to view Datasheet Catalog #    MBS853593
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytochrome P450 19A1 (CYP19A1), Antibody

 Also Known As   

Cytochrome P450 19A1 Antibody

 Product Synonym Names    ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; aromatase; cytochrome P450 19A1; estrogen synthetase
 Product Gene Name   

anti-CYP19A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    613546
 3D Structure    ModBase 3D Structure for P11511
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Cytochrome P450 19A1 antibody detects endogenous levels of total Cytochrome P450 19A1 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human Cytochrome P450 19A1.
 Pathway    Translation
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-CYP19A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CYP19A1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-CYP19A1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-CYP19A1 antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:20000
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 Testing Data of anti-CYP19A1 antibody    anti-CYP19A1 antibody Testing Data image
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 Testing Data #2 of anti-CYP19A1 antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using Cytochrome P450 19A1 antibody.
Western blot analysis of extracts from 293 cells, using Cytochrome P450 19A1 antibody.
anti-CYP19A1 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for CYP19A1. It may not necessarily be applicable to this product.
 NCBI GI #    13904858
 NCBI GeneID    1588
 NCBI Accession #    NP_000094.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000103.3 [Other Products]
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 UniProt Primary Accession #    P11511 [Other Products]
 UniProt Secondary Accession #    Q16731; Q3B764; Q58FA0; Q8IYJ7 [Other Products]
 UniProt Related Accession #    P11511 [Other Products]
 Molecular Weight    24,518 Da [Similar Products]
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 NCBI Official Full Name    aromatase
 NCBI Official Synonym Full Names    cytochrome P450, family 19, subfamily A, polypeptide 1
 NCBI Official Symbol    CYP19A1 [Similar Products]
 NCBI Official Synonym Symbols   
ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM
[Similar Products]
 NCBI Protein Information    aromatase; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; cytochrome P450 19A1; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily XIX (aromatization of androgens)
 UniProt Protein Name    Aromatase
 UniProt Synonym Protein Names   
CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase
 Protein Family    Aromatase
 UniProt Gene Name    CYP19A1 [Similar Products]
 UniProt Synonym Gene Names    ARO1; CYAR; CYP19 [Similar Products]
 UniProt Entry Name    CP19A_HUMAN
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 NCBI Summary for CYP19A1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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 UniProt Comments for CYP19A1    CYP19A1: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family.

Protein type: Oxidoreductase; EC 1.14.14.14; Lipid Metabolism - androgen and estrogen

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum

Molecular Function: electron carrier activity; iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding

Biological Process: steroid metabolic process; xenobiotic metabolic process; androgen metabolic process; estrogen biosynthetic process; steroid biosynthetic process; sterol metabolic process

Disease: Aromatase Deficiency; Aromatase Excess Syndrome
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Product References and Citations for anti-CYP19A1 antibody

   Chen S., Biochem. Biophys. Res. Commun. 135:713-719(1986).
Honda S., Biochem. Biophys. Res. Commun. 198:1153-1160(1994).
Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).
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 Research Articles on CYP19A1    1. These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2, which does not appear to be the case in the human and rat.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP19A1 antibodyPathways associated with anti-CYP19A1 antibody
 Reference Product  PubMed Publications
 HSD17B2 antibody  >313 publications with CYP19A1 and HSD17B2
 SRD5A2 antibody  >153 publications with CYP19A1 and SRD5A2
 FOXL2 antibody  >65 publications with CYP19A1 and FOXL2
 HSD17B1 antibody  >49 publications with CYP19A1 and HSD17B1
 HSD3B1 antibody  >42 publications with CYP19A1 and HSD3B1
 NR0B1 antibody  >20 publications with CYP19A1 and NR0B1
 HSD3B2 antibody  >15 publications with CYP19A1 and HSD3B2
 SRD5A1 antibody  >13 publications with CYP19A1 and SRD5A1
 HSD17B3 antibody  >13 publications with CYP19A1 and HSD17B3
 HSD17B6 antibody  >2 publications with CYP19A1 and HSD17B6
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 Estrogen Biosynthesis Pathway antibodies  Estrogen Biosynthesis Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with anti-CYP19A1 antibodyOrgans/Tissues associated with anti-CYP19A1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4141 publications with CYP19A1 and Breast Neoplasms
 Ovarian Diseases Antibodies  >464 publications with CYP19A1 and Ovarian Diseases
 Osteoporosis Antibodies  >431 publications with CYP19A1 and Osteoporosis
 Adenocarcinoma Antibodies  >394 publications with CYP19A1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >378 publications with CYP19A1 and Neoplasms, Experimental
 Infertility, Female Antibodies  >360 publications with CYP19A1 and Infertility, Female
 Endometriosis Antibodies  >319 publications with CYP19A1 and Endometriosis
 Hyperplasia Antibodies  >281 publications with CYP19A1 and Hyperplasia
 Nervous System Diseases Antibodies  >279 publications with CYP19A1 and Nervous System Diseases
 Polycystic Ovary Syndrome Antibodies  >226 publications with CYP19A1 and Polycystic Ovary Syndrome
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >2364 publications with CYP19A1 and Ovary
 Blood Antibodies  >2074 publications with CYP19A1 and Blood
 Brain Antibodies  >1672 publications with CYP19A1 and Brain
 Testis Antibodies  >986 publications with CYP19A1 and Testis
 Placenta Antibodies  >812 publications with CYP19A1 and Placenta
 Liver Antibodies  >495 publications with CYP19A1 and Liver
 Embryonic Tissue Antibodies  >317 publications with CYP19A1 and Embryonic Tissue
 Vascular Antibodies  >237 publications with CYP19A1 and Vascular
 Adrenal Gland Antibodies  >189 publications with CYP19A1 and Adrenal Gland
 Lung Antibodies  >155 publications with CYP19A1 and Lung
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