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anti-CYP21A2 antibody :: Rabbit anti-Human Cytochrome P450 21A2 Antibody

Scan QR to view Datasheet Catalog #    MBS856347
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytochrome P450 21A2 (CYP21A2), Antibody

 Also Known As   

Cytochrome P450 21A2 Antibody

 Product Synonym Names    Cytochrome P450 21; EC 1.14.99.10; Cytochrome P450 XXI; Steroid 21-hydroxylase; 21-Ohase; P450-C21; P-450c21; P450-C21B; CYP21; CYP21B; CP21A
 Product Gene Name   

anti-CYP21A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    613815
 3D Structure    ModBase 3D Structure for P08686
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 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Cytochrome P450 21A2 antibody detects endogenous levels of total Cytochrome P450 21A2 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human Cytochrome P450 21A2.
 Pathway    Translation
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-CYP21A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CYP21A2 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-CYP21A2 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CYP21A2 antibody    WB: 1:500~1:1000, ELISA: 1:20000
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 Testing Data of anti-CYP21A2 antibody    Western blot analysis of extracts from 293 cells, using Cytochrome P450 21A2 antibody.
anti-CYP21A2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CYP21A2. It may not necessarily be applicable to this product.
 NCBI GI #    323510663
 NCBI GeneID    1589
 NCBI Accession #    NP_000491.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_000500.7 [Other Products]
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 UniProt Primary Accession #    P08686 [Other Products]
 UniProt Secondary Accession #    P04033; Q01204; Q08AG8; Q16749; Q16806; Q5ST44; Q96NU8; A2BHY6 [Other Products]
 UniProt Related Accession #    P08686 [Other Products]
 Molecular Weight    52,597 Da [Similar Products]
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 NCBI Official Full Name    steroid 21-hydroxylase isoform a
 NCBI Official Synonym Full Names    cytochrome P450, family 21, subfamily A, polypeptide 2
 NCBI Official Symbol    CYP21A2 [Similar Products]
 NCBI Official Synonym Symbols   

CAH1; CPS1; CA21H; CYP21; CYP21B; P450c21B

[Similar Products]
 NCBI Protein Information    steroid 21-hydroxylase; 21-OHase; cytochrome P450 XXI; cytochrome P450-C21B; steroid 21-monooxygenase; cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2
 UniProt Protein Name    Steroid 21-hydroxylase
 UniProt Synonym Protein Names   

21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21; Cytochrome P450-C21B

 UniProt Gene Name    CYP21A2 [Similar Products]
 UniProt Synonym Gene Names    CYP21; CYP21B [Similar Products]
 UniProt Entry Name    CP21A_HUMAN
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 NCBI Summary for CYP21A2    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP21A2    CYP21A2: Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. Defects in CYP21A2 are the cause of adrenal hyperplasia type 3 (AH3). AH3 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late onset (NC or LOAH), and 'cryptic' (asymptomatic). Belongs to the cytochrome P450 family.

Protein type: EC 1.14.99.10; Oxidoreductase; Lipid Metabolism - C21-steroid hormone

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: endoplasmic reticulum membrane

Molecular Function: steroid 21-monooxygenase activity; iron ion binding; heme binding; steroid hydroxylase activity; steroid binding

Biological Process: steroid metabolic process; xenobiotic metabolic process; mineralocorticoid biosynthetic process; glucocorticoid biosynthetic process; sterol metabolic process

Disease: Adrenal Hyperplasia, Congenital, Due To 21-hydroxylase Deficiency
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Product References and Citations for anti-CYP21A2 antibody

   Helmberg A., Mol. Endocrinol. 6:1318-1322(1992).
Collier S., Nat. Genet. 3:260-265(1993).
White P.C., Hum. Mutat. 3:373-378(1994).
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 Research Articles on CYP21A2    1. Mutations of CYP21A2 including IVS2-13A/C>G, Arg356Trp and Arg149Pro were associated with congenital adrenal hyperplasia due to 21 hydroxylase deficiency.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Cytochrome P450 21A2 Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS8208176  Cytochrome P450 21A2 Blocking Peptide  MBS856347  Cytochrome P450 21A2 Antibody
 MBS000914  Rabbit Cytochrome P450 21A2 Antibody  MBS8243866  Cytochrome P450 21A2 Blocking Peptide
 MBS8241813  Anti-Cytochrome P450 21A2 Antibody  MBS8215428  Cytochrome P450 21A2 Blocking Peptide
 MBS8208761  Anti-Cytochrome P450 21A2 Antibody  MBS8207772  Anti-Cytochrome P450 21A2 Antibody
Products associated with anti-CYP21A2 antibodyPathways associated with anti-CYP21A2 antibody
 Reference Product  PubMed Publications
 POMC antibody  >25 publications with CYP21A2 and POMC
 HSD3B2 antibody  >10 publications with CYP21A2 and HSD3B2
 TNX antibody  >5 publications with CYP21A2 and TNX
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
 C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies  C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 Glucocorticoid & Mineralcorticoid Metabolism Pathway antibodies  Glucocorticoid & Mineralcorticoid Metabolism Pathway Diagram
 Glucocorticoid Biosynthesis Pathway antibodies  Glucocorticoid Biosynthesis Pathway Diagram
Diseases associated with anti-CYP21A2 antibodyOrgans/Tissues associated with anti-CYP21A2 antibody
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >283 publications with CYP21A2 and Hyperplasia
 Adrenal Hyperplasia, Congenital Antibodies  >281 publications with CYP21A2 and Adrenal Hyperplasia, Congenital
 Congenital adrenal hyperplasia due to 21 hydroxylase deficiency Antibodies  >63 publications with CYP21A2 and Congenital adrenal hyperplasia due to 21 hydroxylase deficiency
 Cardiovascular Diseases Antibodies  >17 publications with CYP21A2 and Cardiovascular Diseases
 Mental Disorders Antibodies  >10 publications with CYP21A2 and Mental Disorders
 Obesity Antibodies  >8 publications with CYP21A2 and Obesity
 Pregnancy Complications Antibodies  >8 publications with CYP21A2 and Pregnancy Complications
 Adenoma Antibodies  >7 publications with CYP21A2 and Adenoma
 Brain Diseases Antibodies  >7 publications with CYP21A2 and Brain Diseases
 Heart Diseases Antibodies  >6 publications with CYP21A2 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Adrenal Gland Antibodies  >34 publications with CYP21A2 and Adrenal Gland
 Ovary Antibodies  >11 publications with CYP21A2 and Ovary
 Testis Antibodies  >8 publications with CYP21A2 and Testis
 Liver Antibodies  >8 publications with CYP21A2 and Liver
 Brain Antibodies  >7 publications with CYP21A2 and Brain
 Heart Antibodies  >6 publications with CYP21A2 and Heart
 Eye Antibodies  >2 publications with CYP21A2 and Eye
 Muscle Antibodies  >2 publications with CYP21A2 and Muscle
 Spleen Antibodies  >1 publications with CYP21A2 and Spleen
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