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anti-CYP2C18 antibody :: Rabbit anti-Human Cytochrome P450 2C8/9/18/19 Antibody

Scan QR to view Datasheet Catalog #    MBS851250
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytochrome P450 2C8/9/18/19 (CYP2C18), Antibody

 Also Known As   

Cytochrome P450 2C8/9/18/19 Antibody

 Product Synonym Names    CP2CI; CPCI; CYPIIC18; EC 1.14.14.1; P450-6B/29C; cytochrome P450 2C18
 Product Gene Name   

anti-CYP2C18 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601131
 3D Structure    ModBase 3D Structure for P33260
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 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Cytochrome P450 2C8/9/18/19 antibody detects endogenous levels of total Cytochrome P450 2C8/9/18/19 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human Cytochrome P450 2C8/9/18/19.
 Pathway    Translation
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-CYP2C18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CYP2C18 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-CYP2C18 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CYP2C18 antibody    WB: 1:500~1:1000, ELISA: 1:20000
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 Testing Data of anti-CYP2C18 antibody    Western blot analysis of extracts from LOVO cells, using Cytochrome P450 2C8/9/18/19 antibody.
anti-CYP2C18 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CYP2C18. It may not necessarily be applicable to this product.
 NCBI GI #    13699816
 NCBI GeneID    1562
 NCBI Accession #    NP_000763.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000772.2 [Other Products]
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 UniProt Primary Accession #    P33260 [Other Products]
 UniProt Secondary Accession #    Q16703; Q16751; Q4VAT5; Q6GRG1; B2R8K2 [Other Products]
 UniProt Related Accession #    P33260 [Other Products]
 Molecular Weight    48,805 Da [Similar Products]
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 NCBI Official Full Name    cytochrome P450 2C18 isoform 1
 NCBI Official Synonym Full Names    cytochrome P450, family 2, subfamily C, polypeptide 18
 NCBI Official Symbol    CYP2C18 [Similar Products]
 NCBI Official Synonym Symbols   
CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C
[Similar Products]
 NCBI Protein Information    cytochrome P450 2C18; CYPIIC18; cytochrome P450-6B/29C; microsomal monooxygenase; unspecific monooxygenase; flavoprotein-linked monooxygenase; (S)-mephenytoin hydroxylase associated cytochrome P450; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18
 UniProt Protein Name    Cytochrome P450 2C18
 UniProt Synonym Protein Names   
CYPIIC18; Cytochrome P450-6b/29c
 Protein Family    Cytochrome
 UniProt Gene Name    CYP2C18 [Similar Products]
 UniProt Entry Name    CP2CI_HUMAN
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 NCBI Summary for CYP2C18    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP2C18    CYP2C18: a member of the cytochrome P450 superfamily of enzymes. Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. Participates in the oxidation of a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Protein type: Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.14.14.1

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm

Molecular Function: iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen binding; monooxygenase activity

Biological Process: xenobiotic metabolic process; exogenous drug catabolic process; epoxygenase P450 pathway
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Product References and Citations for anti-CYP2C18 antibody

   Romkes M., Biochemistry 30:3247-3255(1991).
de Morais S.M., Biochem. Biophys. Res. Commun. 194:194-201(1993).
Deloukas P., Nature 429:375-381(2004).
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 Research Articles on CYP2C18    1. These results suggest that there is no notable influence of sequence variation in the CYP2C genes on longevity in the examined German population
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP2C18 antibodyPathways associated with anti-CYP2C18 antibody
 Reference Product  PubMed Publications
 CYP3A4 antibody  >42 publications with CYP2C18 and CYP3A4
 UGT1A1 antibody  >5 publications with CYP2C18 and UGT1A1
 CYP4F2 antibody  >4 publications with CYP2C18 and CYP4F2
 CYP4A11 antibody  >4 publications with CYP2C18 and CYP4A11
 CYP4F3 antibody  >2 publications with CYP2C18 and CYP4F3
 CYP4F11 antibody  >1 publications with CYP2C18 and CYP4F11
 UGT1A3 antibody  >1 publications with CYP2C18 and UGT1A3
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram
 Retinol Metabolism Pathway antibodies  Retinol Metabolism Pathway Diagram
 Retinol Metabolism Pathway antibodies  Retinol Metabolism Pathway Diagram
Diseases associated with anti-CYP2C18 antibodyOrgans/Tissues associated with anti-CYP2C18 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >4 publications with CYP2C18 and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with CYP2C18 and Liver Neoplasms
 Nervous System Diseases Antibodies  >2 publications with CYP2C18 and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with CYP2C18 and Brain Diseases
 Ovarian Neoplasms Antibodies  >1 publications with CYP2C18 and Ovarian Neoplasms
 Kidney Diseases Antibodies  >1 publications with CYP2C18 and Kidney Diseases
 Inflammation Antibodies  >1 publications with CYP2C18 and Inflammation
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with CYP2C18 and Drug-Related Side Effects and Adverse Reactions
 Drug-Induced Liver Injury Antibodies  >1 publications with CYP2C18 and Drug-Induced Liver Injury
 Immune System Diseases Antibodies  >1 publications with CYP2C18 and Immune System Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >70 publications with CYP2C18 and Liver
 Lung Antibodies  >8 publications with CYP2C18 and Lung
 Brain Antibodies  >6 publications with CYP2C18 and Brain
 Intestine Antibodies  >5 publications with CYP2C18 and Intestine
 Stomach Antibodies  >2 publications with CYP2C18 and Stomach
 Muscle Antibodies  >1 publications with CYP2C18 and Muscle
 Pancreas Antibodies  >1 publications with CYP2C18 and Pancreas
 Uterus Antibodies  >1 publications with CYP2C18 and Uterus
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