Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource rightarrow Antibody rightarrow CYP3A4  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
Our Best Sellers moreseparator
 • colony stimulating factor 1 receptor (CSF1R) ELISA Kit
 • MCP-2 (CCL8) (MCP-2 (CCL8)) Protein
 • Beta-defensin 103 protein (DEFB103A) Recombinant Protein
 • GST Antibody
 • undercarboxylated matrix Gla protein (ucMGP) ELISA Kit
 • S100A1 Antibody
 • MAGEA3 Antibody
 • AXIN1 Antibody
 • Parathormone Intact (PTH) ELISA Kit
 • Vitellogenin-2 (VTG2) Antibody
 • BCAT1 Recombinant Protein
 • Surfactant Associated Protein B (SPB) ELISA Kit
 downarrow more ...
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CYP3A4 antibody :: Rabbit anti-Human Cytochrome P450 3A4 Antibody

Scan QR to view Datasheet Catalog #    MBS001349 anti-CYP3A4 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytochrome P450 3A4 (CYP3A4), Antibody

 Also Known As   

Rabbit Cytochrome P450 3A4 Antibody

 Product Gene Name   

anti-CYP3A4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 7; NC_000007.13 (99354583..99381811, complement). Location: 7q21.1
 OMIM    124010
 3D Structure    ModBase 3D Structure for P08684
Section Bar
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
Section Bar
Section Bar
 Other Notes    Small volumes of anti-CYP3A4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-CYP3A4 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CYP3A4. It may not necessarily be applicable to this product.
 NCBI GI #    322302351
 NCBI GeneID    1576
 NCBI Accession #    NP_001189784.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001202855.2 [Other Products]
Section Bar
 UniProt Primary Accession #    P08684 [Other Products]
 UniProt Secondary Accession #    P05184; Q16757; Q9UK50 [Other Products]
 UniProt Related Accession #    P08684 [Other Products]
 Molecular Weight    57,343 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    cytochrome P450 3A4 isoform 2
 NCBI Official Synonym Full Names    cytochrome P450, family 3, subfamily A, polypeptide 4
 NCBI Official Symbol    CYP3A4 [Similar Products]
 NCBI Official Synonym Symbols   
HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1
[Similar Products]
 NCBI Protein Information    cytochrome P450 3A4; nifedipine oxidase; cytochrome P450 3A3; cytochrome P450 HLp; cytochrome P450-PCN1; cytochrome P450 NF-25; albendazole sulfoxidase; quinine 3-monooxygenase; albendazole monooxygenase; P450-III, steroid inducible; glucocorticoid-inducible P450; 1,8-cineole 2-exo-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
 UniProt Protein Name    Cytochrome P450 3A4
 UniProt Synonym Protein Names   
1,8-cineole 2-exo-monooxygenase (EC:; Albendazole monooxygenase (EC:; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; Cytochrome P450 HLp; Cytochrome P450 NF-25; Cytochrome P450-PCN1; Nifedipine oxidase; Quinine 3-monooxygenase (EC:; Taurochenodeoxycholate 6-alpha-hydroxylase (EC:
 Protein Family    Cytochrome
 UniProt Gene Name    CYP3A4 [Similar Products]
 UniProt Synonym Gene Names    CYP3A3 [Similar Products]
 UniProt Entry Name    CP3A4_HUMAN
Section Bar
 NCBI Summary for CYP3A4    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
Section Bar
 UniProt Comments for CYP3A4    CYP3A4: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide. Belongs to the cytochrome P450 family.

Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Membrane protein, integral; Cell surface; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase; Lipid Metabolism - linoleic acid; EC; Cofactor and Vitamin Metabolism - retinol

Chromosomal Location of Human Ortholog: 7q21.1

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm; integral to membrane

Molecular Function: enzyme binding; quinine 3-monooxygenase activity; iron ion binding; taurochenodeoxycholate 6alpha-hydroxylase activity; albendazole monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity; oxidoreductase activity; oxygen binding; monooxygenase activity; testosterone 6-beta-hydroxylase activity; steroid binding; vitamin D3 25-hydroxylase activity

Biological Process: steroid metabolic process; drug catabolic process; xenobiotic metabolic process; exogenous drug catabolic process; androgen metabolic process; monoterpenoid metabolic process; alkaloid catabolic process; lipid metabolic process; heterocycle metabolic process; drug metabolic process; steroid catabolic process; vitamin D metabolic process
Table BarTOPTable Bar
 Research Articles on CYP3A4    1. Report effect of CYP3A4 inhibition on iloperidone-induced alterations of QT interval.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CYP3A4 antibodyPathways associated with anti-CYP3A4 antibody
 Reference Product  PubMed Publications
 UGT2B7 antibody  >41 publications with CYP3A4 and UGT2B7
 Products by Pathway  Pathway Diagram
 Aflatoxin B1 Metabolism Pathway antibodies  Aflatoxin B1 Metabolism Pathway Diagram
 Benzo(a)pyrene Metabolism Pathway antibodies  Benzo(a)pyrene Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Codeine And Morphine Metabolism Pathway antibodies  Codeine And Morphine Metabolism Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Drug Induction Of Bile Acid Pathway antibodies  Drug Induction Of Bile Acid Pathway Diagram
Diseases associated with anti-CYP3A4 antibodyOrgans/Tissues associated with anti-CYP3A4 antibody
 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >573 publications with CYP3A4 and Drug Toxicity
 Neoplasms Antibodies  >550 publications with CYP3A4 and Neoplasms
 Liver Diseases Antibodies  >277 publications with CYP3A4 and Liver Diseases
 Cardiovascular Diseases Antibodies  >220 publications with CYP3A4 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >217 publications with CYP3A4 and Nervous System Diseases
 Pain Antibodies  >133 publications with CYP3A4 and Pain
 Heart Diseases Antibodies  >127 publications with CYP3A4 and Heart Diseases
 Breast Neoplasms Antibodies  >107 publications with CYP3A4 and Breast Neoplasms
 Hypertension Antibodies  >103 publications with CYP3A4 and Hypertension
 Kidney Diseases Antibodies  >91 publications with CYP3A4 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2724 publications with CYP3A4 and Liver
 Intestine Antibodies  >436 publications with CYP3A4 and Intestine
 Kidney Antibodies  >303 publications with CYP3A4 and Kidney
 Brain Antibodies  >117 publications with CYP3A4 and Brain
 Muscle Antibodies  >74 publications with CYP3A4 and Muscle
 Mouth Antibodies  >27 publications with CYP3A4 and Mouth
 Stomach Antibodies  >24 publications with CYP3A4 and Stomach
 Adrenal Gland Antibodies  >11 publications with CYP3A4 and Adrenal Gland
 Connective Tissue Antibodies  >11 publications with CYP3A4 and Connective Tissue
 Mammary Gland Antibodies  >5 publications with CYP3A4 and Mammary Gland
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions