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anti-CYP51A1 antibody :: Rabbit anti-Human Cytochrome P450 51A1 Antibody

Scan QR to view Datasheet Catalog #    MBS003678 anti-CYP51A1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytochrome P450 51A1 (CYP51A1), Antibody

 Also Known As   

Rabbit Cytochrome P450 51A1 Antibody

 Product Gene Name   

anti-CYP51A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (91741463..91764059, complement). Location: 7q21.2
 OMIM    601637
 3D Structure    ModBase 3D Structure for Q16850
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 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-CYP51A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CYP51A1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CYP51A1. It may not necessarily be applicable to this product.
 NCBI GI #    4503243
 NCBI GeneID    1595
 NCBI Accession #    NP_000777.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000786.3 [Other Products]
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 UniProt Primary Accession #    Q16850 [Other Products]
 UniProt Secondary Accession #    O00770; O00772; Q16784; Q8N1A8; Q99868; A4D1F8; B2RAI4; B4DJ55 [Other Products]
 UniProt Related Accession #    Q16850 [Other Products]
 Molecular Weight    56,806 Da [Similar Products]
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 NCBI Official Full Name    lanosterol 14-alpha demethylase isoform 1
 NCBI Official Synonym Full Names    cytochrome P450, family 51, subfamily A, polypeptide 1
 NCBI Official Symbol    CYP51A1 [Similar Products]
 NCBI Official Synonym Symbols   
LDM; CP51; CYP51; CYPL1; P450L1; P450-14DM
[Similar Products]
 NCBI Protein Information    lanosterol 14-alpha demethylase; CYPLI; cytochrome P450LI; cytochrome P45014DM; cytochrome P450 51A1; cytochrome P450-14DM; lanosterol 14-alpha-demethylase; cytochrome P450, 51 (lanosterol 14-alpha-demethylase)
 UniProt Protein Name    Lanosterol 14-alpha demethylase
 UniProt Synonym Protein Names   
CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase
 UniProt Gene Name    CYP51A1 [Similar Products]
 UniProt Synonym Gene Names    CYP51; LDM [Similar Products]
 UniProt Entry Name    CP51A_HUMAN
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 NCBI Summary for CYP51A1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for CYP51A1    CYP51A1: Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 1.14.13.70; Lipid Metabolism - steroid biosynthesis; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q21.2

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane

Molecular Function: sterol 14-demethylase activity; iron ion binding; heme binding

Biological Process: xenobiotic metabolic process; sterol metabolic process; cholesterol biosynthetic process; steroid biosynthetic process; cholesterol biosynthetic process via 24,25-dihydrolanosterol
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 Research Articles on CYP51A1    1. The new CYP51A1 inhibitor 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LEK-935) on the proteome of primary human hepatocytes were analyzed.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CYP51A1 antibodyDiseases associated with anti-CYP51A1 antibody
 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBP (SREBF) Pathway antibodies  Activation Of Gene Expression By SREBP (SREBF) Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Disease Name  Pubmed Publications
 Mycoses Antibodies  >25 publications with CYP51A1 and Mycoses
 Candidiasis Antibodies  >19 publications with CYP51A1 and Candidiasis
 Neoplasms Antibodies  >9 publications with CYP51A1 and Neoplasms
 Cardiovascular Diseases Antibodies  >5 publications with CYP51A1 and Cardiovascular Diseases
 Liver Diseases Antibodies  >5 publications with CYP51A1 and Liver Diseases
 Inflammation Antibodies  >4 publications with CYP51A1 and Inflammation
 Fatty Liver Antibodies  >3 publications with CYP51A1 and Fatty Liver
 Liver Neoplasms Antibodies  >3 publications with CYP51A1 and Liver Neoplasms
 Drug Toxicity Antibodies  >3 publications with CYP51A1 and Drug Toxicity
 Candidiasis, Oral Antibodies  >3 publications with CYP51A1 and Candidiasis, Oral
Organs/Tissues associated with anti-CYP51A1 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >23 publications with CYP51A1 and Liver
 Blood Antibodies  >17 publications with CYP51A1 and Blood
 Testis Antibodies  >11 publications with CYP51A1 and Testis
 Ovary Antibodies  >7 publications with CYP51A1 and Ovary
 Kidney Antibodies  >6 publications with CYP51A1 and Kidney
 Lung Antibodies  >4 publications with CYP51A1 and Lung
 Skin Antibodies  >2 publications with CYP51A1 and Skin
 Eye Antibodies  >2 publications with CYP51A1 and Eye
 Prostate Antibodies  >2 publications with CYP51A1 and Prostate
 Bone Antibodies  >2 publications with CYP51A1 and Bone
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