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anti-CK5 antibody :: Mouse anti-Human Cytokeratin 5 Antibody

Scan QR to view Datasheet Catalog #    MBS850011
Western Blot (WB)
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytokeratin 5 (CK5), Antibody

 Also Known As   

Cytokeratin 5 Antibody

 Product Synonym Names    K5; KRT5A; KRT5
 Product Gene Name   

anti-CK5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    131760
 3D Structure    ModBase 3D Structure for P13647
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 Isotype    IgG1
 Clone Number    1E1
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of Cytokeratin 5 expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C
 Other Notes    Small volumes of anti-CK5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CK5 antibody

   Cytokeratin 5, also known as CK5, KRT5. It is a member of the keratin gene family. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Cytokeratin 5 is expressed in normal basal cells. Mutations of the Cytokeratin5 gene (KRT5) have been shown to result in the autosomal dominant disorderepidermolysis bullosa (EB). Defects in KRT5 are a cause of epidermolysis bullosa simplex.
 Product Categories/Family for anti-CK5 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-CK5 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CK5 antibody    WB: 1:500-1:2000
ELISA: 1:10000
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 Western Blot (WB) of anti-CK5 antibody    Figure 1. Western blot analysis using CK5 mouse mAb against Hela cell lysate (1).
anti-CK5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CK5. It may not necessarily be applicable to this product.
 NCBI GI #    119395754
 NCBI GeneID    3852
 NCBI Accession #    NP_000415.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000424.3 [Other Products]
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 UniProt Primary Accession #    P13647 [Other Products]
 UniProt Secondary Accession #    Q6PI71; Q6UBJ0; Q8TA91 [Other Products]
 UniProt Related Accession #    P13647 [Other Products]
 Molecular Weight    62.3kDa
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 NCBI Official Full Name    keratin, type II cytoskeletal 5
 NCBI Official Synonym Full Names    keratin 5
 NCBI Official Symbol    KRT5 [Similar Products]
 NCBI Official Synonym Symbols   
K5; CK5; DDD; DDD1; EBS2; KRT5A
[Similar Products]
 NCBI Protein Information    keratin, type II cytoskeletal 5
 UniProt Protein Name    Keratin, type II cytoskeletal 5
 UniProt Synonym Protein Names   
58 kDa cytokeratin; Cytokeratin-5; CK-5; Keratin-5; K5; Type-II keratin Kb5
 UniProt Gene Name    KRT5 [Similar Products]
 UniProt Synonym Gene Names    CK-5; K5 [Similar Products]
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 NCBI Summary for CK5    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CK5    MiscellaneousThere are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
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 Research Articles on CK5    1. EGFR and CK5/6 expression could serve as biomarkers for identifying triple-negative breast cancer patients with poor survival
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CK5 antibodyPathways associated with anti-CK5 antibody
 Reference Product  PubMed Publications
 KRT14 antibody  >70 publications with CK5 and KRT14
 KRT1 antibody  >23 publications with CK5 and KRT1
 KRT18 antibody  >3 publications with CK5 and KRT18
 Products by Pathway  Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
Diseases associated with anti-CK5 antibodyOrgans/Tissues associated with anti-CK5 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >74 publications with CK5 and Neoplasms
 Congenital Abnormalities Antibodies  >71 publications with CK5 and Congenital Abnormalities
 Epidermolysis Bullosa Simplex Antibodies  >70 publications with CK5 and Epidermolysis Bullosa Simplex
 Carcinoma Antibodies  >54 publications with CK5 and Carcinoma
 Breast Neoplasms Antibodies  >32 publications with CK5 and Breast Neoplasms
 Adenocarcinoma Antibodies  >22 publications with CK5 and Adenocarcinoma
 Carcinoma, Basal Cell Antibodies  >20 publications with CK5 and Carcinoma, Basal Cell
 Epidermolysis bullosa simplex with mottled pigmentation Antibodies  >15 publications with CK5 and Epidermolysis bullosa simplex with mottled pigmentation
 Lung Neoplasms Antibodies  >14 publications with CK5 and Lung Neoplasms
 Dowling-Degos Disease Antibodies  >13 publications with CK5 and Dowling-Degos Disease
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >90 publications with CK5 and Skin
 Lung Antibodies  >16 publications with CK5 and Lung
 Blood Antibodies  >8 publications with CK5 and Blood
 Prostate Antibodies  >7 publications with CK5 and Prostate
 Muscle Antibodies  >7 publications with CK5 and Muscle
 Mouth Antibodies  >6 publications with CK5 and Mouth
 Embryonic Tissue Antibodies  >5 publications with CK5 and Embryonic Tissue
 Bladder Antibodies  >5 publications with CK5 and Bladder
 Eye Antibodies  >4 publications with CK5 and Eye
 Thyroid Antibodies  >4 publications with CK5 and Thyroid
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