NP_001073380.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,115 Da
NCBI Official Full Name
dentin matrix acidic phosphoprotein 1 isoform 2
NCBI Official Synonym Full Names
dentin matrix acidic phosphoprotein 1
NCBI Protein Information
dentin matrix acidic phosphoprotein 1
UniProt Protein Name
Dentin matrix acidic phosphoprotein 1
UniProt Synonym Gene Names
NCBI Summary for DMP1
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DMP1
DMP1: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. Defects in DMP1 are the cause of rickets hypophosphatemic autosomal recessive type 1 (ARHR1). A hereditary form of hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss, hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms are bone pain, fractures and growth abnormalities. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component: extracellular region; intracellular membrane-bound organelle; nucleolus; nucleus
Molecular Function: calcium ion binding; integrin binding
Biological Process: extracellular matrix organization and biogenesis
Disease: Hypophosphatemic Rickets, Autosomal Recessive, 1
Research Articles on DMP1
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Products associated with anti-DMP1 antibody
Pathways associated with anti-DMP1 antibody
Diseases associated with anti-DMP1 antibody
Organs/Tissues associated with anti-DMP1 antibody
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