NP_009042.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,070 Da
NCBI Official Full Name
transcription factor Dp-1
NCBI Official Synonym Full Names
transcription factor Dp-1
NCBI Protein Information
transcription factor Dp-1; DRTF1-polypeptide 1; E2F dimerization partner 1; E2F-related transcription factor
UniProt Protein Name
Transcription factor Dp-1
UniProt Synonym Protein Names
DRTF1-polypeptide 1; DRTF1; E2F dimerization partner 1
UniProt Synonym Gene Names
UniProt Entry Name
TFDP1_HUMAN
NCBI Summary for DP-1
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
UniProt Comments for DP-1
TFDP1: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis. Belongs to the E2F/DP family.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: nucleoplasm; transcription factor complex
Molecular Function: protein domain specific binding; protein binding; DNA binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; epidermis development; transcription, DNA-dependent; apoptosis; anoikis; regulation of transcription from RNA polymerase II promoter; cell proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; gene expression; mitotic cell cycle; G1/S transition of mitotic cell cycle
Research Articles on DP-1
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Products associated with anti-DP-1 antibody
Pathways associated with anti-DP-1 antibody
Diseases associated with anti-DP-1 antibody
Organs/Tissues associated with anti-DP-1 antibody
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