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anti-TNFRSF25 antibody :: Rabbit DR3 (ED) Antibody

Scan QR to view Datasheet Catalog #    MBS194070 anti-TNFRSF25 antibody
Unit / Price
0.1 mg  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DR3 (ED) (TNFRSF25), Antibody

 Also Known As   

Anti-DR3 (ED) Antibody

 Product Synonym Names    Anti-DR3 (ED); DR3 (ED)
 Product Gene Name   

anti-TNFRSF25 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (6521211..6526255, complement). Location: 1p36.2
 OMIM    603366
 3D Structure    ModBase 3D Structure for Q93038
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 Host    Rabbit
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 Specificity    Anti-DR3 (ED) [Rabbit antibody to extracellular domain of human cell death receptor DR3.]
This antibody recognizes full-length human DR3 (59 kD).
 Form/Format    100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
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 Antigen    Peptide corresponding to the extracellular domain of human DR3.
 Stabilizer    None
 Preservatives    0.02% sodium azide.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of anti-TNFRSF25 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TNFRSF25 antibody

   Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domaincontaining receptors, TNFR1 and Fas. Another cell death receptor was recently identified and designated DR3, Wsl-1, Apo- 3, TRAMP, and LARD. DR3 is widely expressed in tissues enriched in lymphocytes including peripheral blood, thymus, and spleen. Like TNFR1, DR3 induces apoptosis and NF- kappa B activation.
 Product Categories/Family for anti-TNFRSF25 antibody    Apoptosis Antibodies
 Applications Tested/Suitable for anti-TNFRSF25 antibody   

Immunoblot

 Application Notes for anti-TNFRSF25 antibody    Immunoblotting : use at 1:500-1:1,000 dilution.
Positive control: Whole cell lysate from Jurkat cells.
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NCBI/Uniprot data below describe general gene information for TNFRSF25. It may not necessarily be applicable to this product.
 NCBI GI #    37181738
 NCBI GeneID    8718
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 UniProt Primary Accession #    Q93038 [Other Products]
 UniProt Secondary Accession #    O00275; O00276; O00277; O00278; O00279; O00280; O14865; O14866; B1ALX2; B1ALX3; B7ZLL7 [Other Products]
 UniProt Related Accession #    Q93038 [Other Products]
 Molecular Weight    45,385 Da [Similar Products]
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 NCBI Official Full Name    DR3
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 25
 NCBI Official Symbol    TNFRSF25 [Similar Products]
 NCBI Official Synonym Symbols   
DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 25; protein WSL-1; death receptor 3; OTTHUMP00000000922; OTTHUMP00000000923; OTTHUMP00000000924; OTTHUMP00000000925; OTTHUMP00000220969; OTTHUMP00000220970; OTTHUMP00000220971; OTTHUMP00000220974; OTTHUMP00000220975; death receptor beta; apoptosis inducing receptor; apoptosis-inducing receptor AIR; apoptosis-mediating receptor DR3; apoptosis-mediating receptor TRAMP; death domain receptor 3 soluble form; lymphocyte associated receptor of death; lymphocyte-associated receptor of death; translocating chain-association membrane protein; tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 25
 UniProt Synonym Protein Names   
Apo-3; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; Death receptor 3; Lymphocyte-associated receptor of death; LARD; Protein WSL; Protein WSL-1
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF25 [Similar Products]
 UniProt Synonym Gene Names    APO3; DDR3; DR3; TNFRSF12; WSL; WSL1 [Similar Products]
 UniProt Entry Name    TNR25_HUMAN
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 NCBI Summary for TNFRSF25    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq]
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 UniProt Comments for TNFRSF25    TNFRSF25: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4. Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate. 12 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Apoptosis

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; cytosol

Molecular Function: tumor necrosis factor receptor activity; receptor activity

Biological Process: regulation of apoptosis; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; apoptosis; signal transduction
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 Research Articles on TNFRSF25    1. role of TNFRSF25:TNFSF15 in disease and health
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNFRSF25 antibodyPathways associated with anti-TNFRSF25 antibody
 Reference Product  PubMed Publications
 TNFSF15 antibody  >23 publications with TNFRSF25 and TNFSF15
 TRADD antibody  >11 publications with TNFRSF25 and TRADD
 TRAF2 antibody  >5 publications with TNFRSF25 and TRAF2
 TNFSF12 antibody  >4 publications with TNFRSF25 and TNFSF12
 BAG4 antibody  >4 publications with TNFRSF25 and BAG4
 TNFRSF1A antibody  >3 publications with TNFRSF25 and TNFRSF1A
 MAPK1 antibody  >2 publications with TNFRSF25 and MAPK1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with anti-TNFRSF25 antibodyOrgans/Tissues associated with anti-TNFRSF25 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >49 publications with TNFRSF25 and Neoplasms
 Male Urogenital Diseases Antibodies  >21 publications with TNFRSF25 and Male Urogenital Diseases
 Carcinoma Antibodies  >17 publications with TNFRSF25 and Carcinoma
 Prostatic Neoplasms Antibodies  >16 publications with TNFRSF25 and Prostatic Neoplasms
 Inflammation Antibodies  >14 publications with TNFRSF25 and Inflammation
 Adenocarcinoma Antibodies  >13 publications with TNFRSF25 and Adenocarcinoma
 Nervous System Diseases Antibodies  >9 publications with TNFRSF25 and Nervous System Diseases
 Arthritis, Rheumatoid Antibodies  >7 publications with TNFRSF25 and Arthritis, Rheumatoid
 Female Urogenital Diseases Antibodies  >6 publications with TNFRSF25 and Female Urogenital Diseases
 Lymphoma Antibodies  >5 publications with TNFRSF25 and Lymphoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >40 publications with TNFRSF25 and Blood
 Lung Antibodies  >7 publications with TNFRSF25 and Lung
 Brain Antibodies  >7 publications with TNFRSF25 and Brain
 Intestine Antibodies  >5 publications with TNFRSF25 and Intestine
 Spleen Antibodies  >5 publications with TNFRSF25 and Spleen
 Thymus Antibodies  >4 publications with TNFRSF25 and Thymus
 Heart Antibodies  >3 publications with TNFRSF25 and Heart
 Embryonic Tissue Antibodies  >2 publications with TNFRSF25 and Embryonic Tissue
 Connective Tissue Antibodies  >2 publications with TNFRSF25 and Connective Tissue
 Pancreas Antibodies  >1 publications with TNFRSF25 and Pancreas
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