NP_001019831.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
141,164 Da
NCBI Official Full Name
kalirin isoform 1
NCBI Official Synonym Full Names
kalirin RhoGEF kinase
NCBI Official Synonym Symbols
DUO; CHD5; DUET; TRAD; CHDS5; HAPIP; ARHGEF24 [Similar Products]
NCBI Protein Information
kalirin
UniProt Protein Name
Kalirin
UniProt Synonym Protein Names
Huntingtin-associated protein-interacting protein; Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
NCBI Summary for DUET
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
UniProt Comments for DUET
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Research Articles on DUET
Precautions
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Disclaimer
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Products associated with anti-DUET antibody
Pathways associated with anti-DUET antibody
Diseases associated with anti-DUET antibody
Organs/Tissues associated with anti-DUET antibody
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