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anti-DVL3 antibody :: Rabbit anti-Human, mouse DVL3 Antibody

Scan QR to view Datasheet Catalog #    MBS004486 anti-DVL3 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DVL3, Antibody

 Also Known As   

Rabbit DVL3 Antibody

 Product Gene Name   

anti-DVL3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (183873284..183891314). Location: 3q27
 OMIM    601368
 3D Structure    ModBase 3D Structure for Q92997
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-DVL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DVL3 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for DVL3. It may not necessarily be applicable to this product.
 NCBI GI #    41406097
 NCBI GeneID    1857
 NCBI Accession #    NP_004414.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_004423.3 [Other Products]
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 UniProt Primary Accession #    Q92997 [Other Products]
 UniProt Secondary Accession #    O14642; Q13531; Q8N5E9; Q92607; D3DNT0 [Other Products]
 UniProt Related Accession #    Q92997 [Other Products]
 Molecular Weight    78,055 Da
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 NCBI Official Full Name    segment polarity protein dishevelled homolog DVL-3
 NCBI Official Synonym Full Names    dishevelled segment polarity protein 3
 NCBI Official Symbol    DVL3 [Similar Products]
 NCBI Protein Information    segment polarity protein dishevelled homolog DVL-3; DSH homolog 3; dishevelled-3; dishevelled, dsh homolog 3; dishevelled 3 (homologous to Drosophila dsh)
 UniProt Protein Name    Segment polarity protein dishevelled homolog DVL-3
 UniProt Synonym Protein Names   
DSH homolog 3
 Protein Family    Segment polarity protein dishevelled
 UniProt Gene Name    DVL3 [Similar Products]
 UniProt Synonym Gene Names    KIAA0208; Dishevelled-3 [Similar Products]
 UniProt Entry Name    DVL3_HUMAN
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 NCBI Summary for DVL3    This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DVL3    DVL3: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: cytosol

Molecular Function: protein binding; protease binding; protein heterodimerization activity; frizzled binding; beta-catenin binding; receptor binding

Biological Process: response to drug; positive regulation of JNK activity; Wnt receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin; positive regulation of protein amino acid phosphorylation
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 Research Articles on DVL3    1. Dvl3 protein transduce signals via the Wnt proteins non canonical pathways, namely via NFAT protein and Src kinase and novel NPM-ALK interacting proteins and possibly NPM-ALK substrates.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DVL3 antibodyPathways associated with anti-DVL3 antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >25 publications with DVL3 and CTNNB1
 DVL1 antibody  >16 publications with DVL3 and DVL1
 VANGL1 antibody  >5 publications with DVL3 and VANGL1
 AXIN1 antibody  >2 publications with DVL3 and AXIN1
 MARK2 antibody  >1 publications with DVL3 and MARK2
 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
Diseases associated with anti-DVL3 antibodyOrgans/Tissues associated with anti-DVL3 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >12 publications with DVL3 and Neoplasms
 Nervous System Diseases Antibodies  >3 publications with DVL3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >3 publications with DVL3 and Cardiovascular Diseases
 Melanoma Antibodies  >1 publications with DVL3 and Melanoma
 Brain Diseases Antibodies  >1 publications with DVL3 and Brain Diseases
 Dementia Antibodies  >1 publications with DVL3 and Dementia
 Liver Neoplasms Antibodies  >1 publications with DVL3 and Liver Neoplasms
 Learning Disorders Antibodies  >1 publications with DVL3 and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with DVL3 and Brain
 Embryonic Tissue Antibodies  >6 publications with DVL3 and Embryonic Tissue
 Lung Antibodies  >5 publications with DVL3 and Lung
 Heart Antibodies  >4 publications with DVL3 and Heart
 Kidney Antibodies  >4 publications with DVL3 and Kidney
 Ovary Antibodies  >3 publications with DVL3 and Ovary
 Nerve Antibodies  >3 publications with DVL3 and Nerve
 Prostate Antibodies  >2 publications with DVL3 and Prostate
 Blood Antibodies  >2 publications with DVL3 and Blood
 Bone Antibodies  >2 publications with DVL3 and Bone
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