NP_001387.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1
NCBI Official Synonym Full Names
dual specificity tyrosine phosphorylation regulated kinase 1A
NCBI Official Synonym Symbols
MNB; DYRK; HP86; MNBH; MRD7; DYRK1 [Similar Products]
NCBI Protein Information
dual specificity tyrosine-phosphorylation-regulated kinase 1A
UniProt Protein Name
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
UniProt Synonym Protein Names
Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog; MNBH; hMNB
UniProt Synonym Gene Names
NCBI Summary for DYRK1A/B
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for DYRK1A/B
DYRK1A: a dual-specificity protein kinase of the DYRK family. Contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. May play a significant role in a pathway regulating cell proliferation and may be involved in brain development. Its gene is localized in the Down syndrome (DS) critical region of chromosome 21, and is a strong candidate gene for learning defects associated with Down syndrome. Overexpression in mice gives rise to neurological abnormalities similar to those observed in DS. Five splice-variant isoforms have been described.
Protein type: CMGC group; DYRK family; Dyrk1 subfamily; EC 2.7.12.2; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of Human Ortholog: 21q22.13
Cellular Component: nuclear speck; nucleoplasm; nucleus
Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein self-association; protein serine/threonine kinase activity; protein-tyrosine kinase activity; tau protein binding
Biological Process: circadian rhythm; negative regulation of DNA damage response, signal transduction by p53 class mediator; nervous system development; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation
Disease: Mental Retardation, Autosomal Dominant 7
Research Articles on DYRK1A/B
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Products associated with anti-DYRK1A/B antibody
Pathways associated with anti-DYRK1A/B antibody
Diseases associated with anti-DYRK1A/B antibody
Organs/Tissues associated with anti-DYRK1A/B antibody
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