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anti-Dab1 antibody :: Rabbit Dab1 (Phospho-Tyr232) Antibody

Scan QR to view Datasheet Catalog #    MBS000209 anti-Dab1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dab1 (Phospho-Tyr232), Antibody

 Also Known As   

Rabbit Dab1 (Phospho-Tyr232) Antibody

 Product Gene Name   

anti-Dab1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (57463579..58716211, complement). Location: 1p32-p31
 OMIM    603448
 3D Structure    ModBase 3D Structure for O75553
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-Dab1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-Dab1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for Dab1. It may not necessarily be applicable to this product.
 NCBI GI #    33350928
 NCBI GeneID    1600
 NCBI Accession #    NP_066566.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_021080.3 [Other Products]
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 UniProt Primary Accession #    O75553 [Other Products]
 UniProt Secondary Accession #    Q4LE59; Q5T6M6; Q5T6M9; Q5T835; Q5T836; Q5T837; Q6NWS9; Q6NWT0; Q6NWT1; A4FU90; B3KTG3 [Other Products]
 UniProt Related Accession #    O75553 [Other Products]
 Molecular Weight    63,775 Da
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 NCBI Official Full Name    disabled homolog 1
 NCBI Official Synonym Full Names    Dab, reelin signal transducer, homolog 1 (Drosophila)
 NCBI Official Symbol    DAB1 [Similar Products]
 NCBI Protein Information    disabled homolog 1
 UniProt Protein Name    Disabled homolog 1
 Protein Family    Disabled
 UniProt Gene Name    DAB1 [Similar Products]
 UniProt Entry Name    DAB1_HUMAN
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 NCBI Summary for Dab1    The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Dab1    DAB1: an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1p32-p31

Cellular Component: neuron projection; cell soma; membrane; apical part of cell; perinuclear region of cytoplasm; postsynaptic density; cytosol; brush border

Molecular Function: phosphoinositide 3-kinase binding

Biological Process: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; response to drug; Golgi localization; cerebellum structural organization; ventral spinal cord development; negative regulation of cell adhesion; adult walking behavior; small GTPase mediated signal transduction; radial glia guided migration of Purkinje cell; positive regulation of protein kinase activity; negative regulation of astrocyte differentiation; dendrite development; midgut development; negative regulation of axonogenesis; cerebral cortex radially oriented cell migration; positive regulation of neuron differentiation; negative regulation of JAK-STAT cascade
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 Research Articles on Dab1    1. Variation in genes encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1, was examined.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Dab1 antibodyPathways associated with anti-Dab1 antibody
 Reference Product  PubMed Publications
 VLDLR antibody  >62 publications with Dab1 and VLDLR
 SRC antibody  >48 publications with Dab1 and SRC
 RELN antibody  >28 publications with Dab1 and RELN
 APP antibody  >20 publications with Dab1 and APP
 CDK5 antibody  >15 publications with Dab1 and CDK5
 CRKL antibody  >13 publications with Dab1 and CRKL
 CRK antibody  >12 publications with Dab1 and CRK
 LRP8 antibody  >7 publications with Dab1 and LRP8
 PAFAH1B1 antibody  >5 publications with Dab1 and PAFAH1B1
 APLP1 antibody  >4 publications with Dab1 and APLP1
 Products by Pathway  Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
 Reelin Signaling Pathway antibodies  Reelin Signaling Pathway Diagram
Diseases associated with anti-Dab1 antibodyOrgans/Tissues associated with anti-Dab1 antibody
 Disease Name  Pubmed Publications
 Movement Disorders Antibodies  >9 publications with Dab1 and Movement Disorders
 Disease Models, Animal Antibodies  >4 publications with Dab1 and Disease Models, Animal
 Pain Antibodies  >3 publications with Dab1 and Pain
 Neoplasms, Experimental Antibodies  >3 publications with Dab1 and Neoplasms, Experimental
 Inflammation Antibodies  >2 publications with Dab1 and Inflammation
 Mood Disorders Antibodies  >2 publications with Dab1 and Mood Disorders
 Abnormalities, Drug-Induced Antibodies  >1 publications with Dab1 and Abnormalities, Drug-Induced
 Microcephaly Antibodies  >1 publications with Dab1 and Microcephaly
 Neurobehavioral Manifestations Antibodies  >1 publications with Dab1 and Neurobehavioral Manifestations
 Breast Neoplasms Antibodies  >1 publications with Dab1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >229 publications with Dab1 and Brain
 Embryonic Tissue Antibodies  >72 publications with Dab1 and Embryonic Tissue
 Eye Antibodies  >14 publications with Dab1 and Eye
 Liver Antibodies  >7 publications with Dab1 and Liver
 Kidney Antibodies  >5 publications with Dab1 and Kidney
 Lung Antibodies  >2 publications with Dab1 and Lung
 Testis Antibodies  >1 publications with Dab1 and Testis
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