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anti-DAXX antibody :: Rabbit Daxx (CT) Antibody

Scan QR to view Datasheet Catalog #    MBS194057 anti-DAXX antibody
Unit / Price
0.1 mg  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Daxx (CT), Antibody

 Also Known As   

Anti-Daxx (CT) Antibody

 Product Synonym Names    Anti-Daxx (CT); DAXX (CT)
 Product Gene Name   

anti-DAXX antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (33286335..33290793, complement). Location: 6p21.3
 3D Structure    ModBase 3D Structure for Q4VX54
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 Host    Rabbit
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 Specificity    Anti-Daxx (CT) [Rabbit antibody to peptide at C-terminus of human Fas binding protein DAXX.]
This antibody recognizes full-length human, monkey, and mouse Daxx (120 kD).
 Form/Format    100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
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 Antigen    Peptide corresponding to Cterminus of human Daxx.
 Stabilizer    None
 Preservatives    0.02% sodium azide.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of anti-DAXX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DAXX antibody

   Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain-containing receptors, TNFR1 and Fas. A novel Fas binding protein was recently cloned from human and mouse and designated Daxx. Daxx binds specifically to the Fas death domain, enhances Fas induced apoptosis, and activates the Jun Nterminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues, indicating its important function in Fas signaling pathways.
 Product Categories/Family for anti-DAXX antibody    Apoptosis Antibodies
 Applications Tested/Suitable for anti-DAXX antibody   

Immunoblot

 Application Notes for anti-DAXX antibody    Immunoblotting: use at 1:500-1:1,000 dilution.
Positive control: Whole cell lysate from HeLa cells.
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NCBI/Uniprot data below describe general gene information for DAXX. It may not necessarily be applicable to this product.
 NCBI GI #    2253709
 NCBI GeneID    1616
 NCBI Accession #    AAB63043.1 [Other Products]
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 UniProt Primary Accession #    Q4VX54 [Other Products]
 UniProt Secondary Accession #    Q5STK8 [Other Products]
 UniProt Related Accession #    Q4VX54; Q53F85; Q59FG7; Q5STK8; Q5STR5; Q9UER7 [Other Products]
 Molecular Weight    19,115 Da [Similar Products]
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 NCBI Official Full Name    Daxx
 NCBI Official Synonym Full Names    death-domain associated protein
 NCBI Official Symbol    DAXX [Similar Products]
 NCBI Official Synonym Symbols   
DAP6; EAP1; BING2; MGC126245; MGC126246
[Similar Products]
 NCBI Protein Information    death domain-associated protein 6; hDaxx; OTTHUMP00000029289; OTTHUMP00000029290; Fas-binding protein; CENP-C binding protein; ETS1-associated protein 1; death-associated protein 6; fas death domain-associated protein
 UniProt Protein Name    Death-associated protein 6
 Protein Family    Death domain-associated protein
 UniProt Gene Name    DAXX [Similar Products]
 UniProt Entry Name    Q4VX54_HUMAN
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 NCBI Summary for DAXX    This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
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 UniProt Comments for DAXX    DAXX: a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK1 in response to signaling from FAS and TGF-betaR2. Glucose deprivation activates the ASK1-SEK1-JNK1-HIPK1 pathway, relocalizing Daxx from the nucleus to the cytoplasm, where Daxx binds to ASK1, and subsequently leads to ASK1 oligomerization. Interaction with HSP27 may prevent interaction with TGF-betaR2 and ASK1 and block DAXX-mediated apoptosis. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Two alternatively spliced isoforms have been described.

Protein type: Transcription, coactivator/corepressor; Nucleolus; Apoptosis; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: heterochromatin; PML body; cytoplasm; nucleolus; cytosol; nucleus; chromosome, pericentric region

Molecular Function: protein homodimerization activity; histone binding; p53 binding; protein N-terminus binding; protein kinase binding; transcription factor binding; protein binding; enzyme binding; androgen receptor binding; ubiquitin protein ligase binding; heat shock protein binding; receptor signaling protein activity; transcription corepressor activity; protein kinase activator activity

Biological Process: chromatin remodeling; nucleosome assembly; transcription, DNA-dependent; viral reproduction; cytokinesis after mitosis; regulation of transcription, DNA-dependent; induction of apoptosis via death domain receptors; regulation of protein ubiquitination; apoptosis; positive regulation of protein kinase activity; androgen receptor signaling pathway; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; activation of JNK activity
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 Research Articles on DAXX    1. Using the transcriptional coregulator Daxx as a model, we show that SUMO paralog-selective binding and conjugation are regulated by phosphorylation of the Daxx SUMO-interacting motif (SIM).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DAXX antibodyPathways associated with anti-DAXX antibody
 Reference Product  PubMed Publications
 PML antibody  >102 publications with DAXX and PML
 FAS antibody  >94 publications with DAXX and FAS
 ATRX antibody  >27 publications with DAXX and ATRX
 MAP3K5 antibody  >17 publications with DAXX and MAP3K5
 MDM2 antibody  >11 publications with DAXX and MDM2
 FASLG antibody  >9 publications with DAXX and FASLG
 TP53 antibody  >6 publications with DAXX and TP53
 ETS1 antibody  >6 publications with DAXX and ETS1
 HSF1 antibody  >6 publications with DAXX and HSF1
 HIPK2 antibody  >6 publications with DAXX and HIPK2
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 HIV-1 Nef: Negative Effector Of Fas And TNF-alpha Pathway antibodies  HIV-1 Nef: Negative Effector Of Fas And TNF-alpha Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with anti-DAXX antibodyOrgans/Tissues associated with anti-DAXX antibody
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >80 publications with DAXX and Leukemia
 Neoplasms Antibodies  >56 publications with DAXX and Neoplasms
 Necrosis Antibodies  >21 publications with DAXX and Necrosis
 Leukemia, Myeloid Antibodies  >19 publications with DAXX and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >17 publications with DAXX and Leukemia, Myeloid, Acute
 Leukemia, Promyelocytic, Acute Antibodies  >16 publications with DAXX and Leukemia, Promyelocytic, Acute
 Nervous System Diseases Antibodies  >16 publications with DAXX and Nervous System Diseases
 Carcinoma Antibodies  >14 publications with DAXX and Carcinoma
 Lymphoma Antibodies  >10 publications with DAXX and Lymphoma
 Herpes Simplex Antibodies  >10 publications with DAXX and Herpes Simplex
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with DAXX and Blood
 Brain Antibodies  >19 publications with DAXX and Brain
 Prostate Antibodies  >14 publications with DAXX and Prostate
 Kidney Antibodies  >7 publications with DAXX and Kidney
 Muscle Antibodies  >7 publications with DAXX and Muscle
 Liver Antibodies  >6 publications with DAXX and Liver
 Heart Antibodies  >6 publications with DAXX and Heart
 Bone Antibodies  >5 publications with DAXX and Bone
 Bone Marrow Antibodies  >5 publications with DAXX and Bone Marrow
 Embryonic Tissue Antibodies  >3 publications with DAXX and Embryonic Tissue
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