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CD324 antibody :: E-Cadherin/CD324 Antibody

Scan QR to view Datasheet Catalog #    MBS4380381
Immunohistochemistry (IHC)
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

E-Cadherin/CD324, Antibody

★Popular Item★
 Also Known As   

E-Cadherin/CD324 (Intercellular Junction Marker)

 Product Synonym Names    Arc 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD324; CDH1; CDHE; E-Cad/CTF3; E-cadherin; ECAD; Epithelial cadherin; epithelial calcium dependent adhesion protein; Liver cell adhesion molecule (LCAM); Uvomorulin (UVO)
 Product Gene Name   

CD324 antibody

[Similar Products]
 Product Synonym Gene Name    CDH1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P12830
 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    SPM381
 Host    Mouse
 Species Reactivity    Human. Others not known
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 Specificity    Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Recombinant human full-length E-Cadherin protein
 Cellular Localization    Cell Surface
 Hu-chromosome Location    16q22.1
 Positive Control    LS174T, Raji, HT29, SK-BR3 cells. Prostate or Colon carcinomas.
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of CD324 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for CD324 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin

 Application Notes for CD324 antibody    FC/FACS: 0.5-1ug/million cells
IF: 0.5-1ug/ml
WB: 0.5-1ug/ml
IHC-F: 0.5-1ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
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 Immunohistochemistry (IHC) of CD324 antibody    Formalin-fixed, paraffin-embedded human Skin stained with E-Cadherin Monoclonal Antibody (SPM381).
CD324 antibody  Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD324. It may not necessarily be applicable to this product.
 NCBI GI #    953768348
 NCBI GeneID    999
 NCBI Accession #    NP_001304113.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001317184.1 [Other Products]
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 UniProt Primary Accession #    P12830 [Other Products]
 UniProt Secondary Accession #    Q13799; Q14216; Q15855; Q16194; Q4PJ14; Q9UII8; A8K1U7 [Other Products]
 Molecular Weight    120-80kDa (Mature); 135kDa (Precursor)
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 NCBI Official Full Name    cadherin-1 isoform 2
 UniProt Protein Name    Cadherin-1
 UniProt Synonym Protein Names   
CAM 120/80; Epithelial cadherin; E-cadherin
 UniProt Gene Name    CDH1 [Similar Products]
 UniProt Synonym Gene Names    CDHE; UVO; E-cadherin [Similar Products]
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 UniProt Comments for CD324    Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
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Product References and Citations for CD324 antibody

   Umbas, R., et al. 1992. Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer. Cancer Res. 52: 5104-5109.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD324 antibody Pathways associated with CD324 antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >234 publications with CD324 and CTNNB1
 SNAI1 antibody  >76 publications with CD324 and SNAI1
 EGFR antibody  >65 publications with CD324 and EGFR
 SRC antibody  >20 publications with CD324 and SRC
 CTNNA1 antibody  >19 publications with CD324 and CTNNA1
 VCL antibody  >2 publications with CD324 and VCL
 CBLL1 antibody  >2 publications with CD324 and CBLL1
 UBC antibody  >1 publications with CD324 and UBC
 CTNND1 antibody  >1 publications with CD324 and CTNND1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
Diseases associated with CD324 antibody Organs/Tissues associated with CD324 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >641 publications with CD324 and Carcinoma
 Stomach Neoplasms Antibodies  >366 publications with CD324 and Stomach Neoplasms
 Breast Neoplasms Antibodies  >309 publications with CD324 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >224 publications with CD324 and Neoplasm Metastasis
 Neoplasm Invasiveness Antibodies  >206 publications with CD324 and Neoplasm Invasiveness
 Disease Progression Antibodies  >144 publications with CD324 and Disease Progression
 Colorectal Neoplasms Antibodies  >133 publications with CD324 and Colorectal Neoplasms
 Lung Neoplasms Antibodies  >99 publications with CD324 and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >92 publications with CD324 and Carcinoma, Squamous Cell
 Lung Diseases Antibodies  >92 publications with CD324 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Stomach Antibodies  >383 publications with CD324 and Stomach
 Blood Antibodies  >142 publications with CD324 and Blood
 Lung Antibodies  >140 publications with CD324 and Lung
 Lymph Node Antibodies  >123 publications with CD324 and Lymph Node
 Liver Antibodies  >103 publications with CD324 and Liver
 Brain Antibodies  >76 publications with CD324 and Brain
 Prostate Antibodies  >70 publications with CD324 and Prostate
 Embryonic Tissue Antibodies  >54 publications with CD324 and Embryonic Tissue
 Kidney Antibodies  >52 publications with CD324 and Kidney
 Muscle Antibodies  >40 publications with CD324 and Muscle
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