NP_001129611.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,510 Da
NCBI Official Full Name
transcription factor E2-alpha isoform E47
NCBI Official Synonym Full Names
transcription factor 3
NCBI Official Synonym Symbols
E2A; E47; p75; AGM8; ITF1; VDIR; TCF-3; bHLHb21 [Similar Products]
NCBI Protein Information
transcription factor E2-alpha
UniProt Protein Name
Transcription factor E2-alpha
UniProt Synonym Protein Names
Class B basic helix-loop-helix protein 21; bHLHb21; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription factor 3; TCF-3; Transcription factor ITF-1
UniProt Synonym Gene Names
NCBI Summary for E2A
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
UniProt Comments for E2A
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
Product References and Citations for anti-E2A antibody
Kamps M.P., Cell 60:547-555(1990). Nourse J., Cell 60:535-545(1990). Grimwood J., Nature 428:529-535(2004).
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Products associated with anti-E2A antibody
Pathways associated with anti-E2A antibody
Diseases associated with anti-E2A antibody
Organs/Tissues associated with anti-E2A antibody
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