NP_002926.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,385 Da
NCBI Official Full Name
eosinophil cationic protein
NCBI Official Synonym Full Names
ribonuclease A family member 3
NCBI Protein Information
eosinophil cationic protein
UniProt Protein Name
Eosinophil cationic protein
UniProt Synonym Protein Names
Ribonuclease 3; RNase 3
UniProt Synonym Gene Names
NCBI Summary for ECP
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]
UniProt Comments for ECP
RNASE3: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. Belongs to the pancreatic ribonuclease family.
Protein type: EC 3.1.27.-; Ribonuclease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: extracellular region; extracellular space
Molecular Function: endonuclease activity; ribonuclease activity
Biological Process: antibacterial humoral response; defense response to Gram-positive bacterium; innate immune response in mucosa; RNA catabolic process
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Products associated with anti-ECP antibody
Pathways associated with anti-ECP antibody
Diseases associated with anti-ECP antibody
Organs/Tissues associated with anti-ECP antibody
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