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EGFR antibody :: EGFR (Epidermal Growth Factor Receptor) Antibody

Scan QR to view Datasheet Catalog #    MBS439925 EGFR antibody
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EGFR (Epidermal Growth Factor Receptor), Antibody

★Popular Item★
 Also Known As   

EGFR (Epidermal Growth Factor Receptor)

 Product Synonym Names    Erbb1; ERBB1; Errp; HER1; mENA; PIG61; Proto-oncogene c-ErbB-1; Receptor Tyrosine Protein Kinase; ErbB1; Urogastrone; wa2; Wa5
 Product Gene Name   

EGFR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P00533
 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    GFR/1667
 Host    Mouse
 Species Reactivity    Human. Others not known.
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 Specificity    This MAb recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1mg/ml.
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 Immunogen    Recombinant full-length human EGFR protein
 Cellular Localization    Cell Surface
 Hu-chromosome Location    7p11.2
 Positive Control    A431 cells. Placenta, Breast, Colon or Bladder cancer
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of EGFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for EGFR antibody   

Immunohistochemistry (IHC) Formalin

 Application Notes for EGFR antibody    IHC-F: 1-2ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
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NCBI/Uniprot data below describe general gene information for EGFR. It may not necessarily be applicable to this product.
 NCBI GI #    29725609
 NCBI GeneID    1956
 NCBI Accession #    NP_005219.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005228.4 [Other Products]
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 UniProt Primary Accession #    P00533 [Other Products]
 UniProt Secondary Accession #    O00688; O00732; P06268; Q14225; Q68GS5; Q92795; Q9BZS2; Q9GZX1; Q9H2C9; Q9H3C9; Q9UMD7 [Other Products]
 UniProt Related Accession #    P00533 [Other Products]
 Molecular Weight    ~170kDa (wild type); ~145kDa (vIII variant)
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 NCBI Official Full Name    epidermal growth factor receptor isoform a
 NCBI Official Synonym Full Names    epidermal growth factor receptor
 NCBI Official Symbol    EGFR [Similar Products]
 NCBI Official Synonym Symbols   
ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
[Similar Products]
 NCBI Protein Information    epidermal growth factor receptor
 UniProt Protein Name    Epidermal growth factor receptor
 UniProt Synonym Protein Names   
Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
 Protein Family    Epidermal growth factor receptor
 UniProt Gene Name    EGFR [Similar Products]
 UniProt Synonym Gene Names    ERBB; ERBB1; HER1 [Similar Products]
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 NCBI Summary for EGFR    The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
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 UniProt Comments for EGFR    Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Plays a role in enhancing learning and memory performance ().
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Product References and Citations for EGFR antibody

   Tungekar MF et. al. Journal of Clinical Pathology. 51: 583-587 (1998).
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 Research Articles on EGFR    1. The prognosis of patients with the single rare non-small cell lung cancer EGFR mutations treated with tyrosine kinase inhibitors is poor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EGFR antibody Pathways associated with EGFR antibody
 Reference Product  PubMed Publications
 EGF antibody  >4897 publications with EGFR and EGF
 ERBB2 antibody  >2515 publications with EGFR and ERBB2
 MET antibody  >673 publications with EGFR and MET
 MAPK1 antibody  >421 publications with EGFR and MAPK1
 STAT3 antibody  >348 publications with EGFR and STAT3
 ERBB3 antibody  >332 publications with EGFR and ERBB3
 CTNNB1 antibody  >271 publications with EGFR and CTNNB1
 GRB2 antibody  >229 publications with EGFR and GRB2
 ERBB4 antibody  >224 publications with EGFR and ERBB4
 CBL antibody  >221 publications with EGFR and CBL
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
Diseases associated with EGFR antibody Organs/Tissues associated with EGFR antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13105 publications with EGFR and Neoplasms
 Carcinoma Antibodies  >7383 publications with EGFR and Carcinoma
 Lung Neoplasms Antibodies  >3848 publications with EGFR and Lung Neoplasms
 Adenocarcinoma Antibodies  >2924 publications with EGFR and Adenocarcinoma
 Kidney Diseases Antibodies  >2669 publications with EGFR and Kidney Diseases
 Small Cell Lung Carcinoma Antibodies  >2587 publications with EGFR and Small Cell Lung Carcinoma
 Carcinoma, Non-Small-Cell Lung Antibodies  >2553 publications with EGFR and Carcinoma, Non-Small-Cell Lung
 Breast Neoplasms Antibodies  >2207 publications with EGFR and Breast Neoplasms
 Disease Progression Antibodies  >2145 publications with EGFR and Disease Progression
 Carcinoma, Squamous Cell Antibodies  >2042 publications with EGFR and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5123 publications with EGFR and Lung
 Kidney Antibodies  >3722 publications with EGFR and Kidney
 Vascular Antibodies  >1971 publications with EGFR and Vascular
 Brain Antibodies  >1600 publications with EGFR and Brain
 Skin Antibodies  >979 publications with EGFR and Skin
 Liver Antibodies  >953 publications with EGFR and Liver
 Heart Antibodies  >806 publications with EGFR and Heart
 Prostate Antibodies  >571 publications with EGFR and Prostate
 Muscle Antibodies  >556 publications with EGFR and Muscle
 Stomach Antibodies  >403 publications with EGFR and Stomach
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