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anti-EGFR antibody :: Rabbit EGFR Antibody

Scan QR to view Datasheet Catalog #    MBS851834
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EGFR, Antibody

 Also Known As   

EGFR (Phospho-Ser1071) Antibody

 Product Synonym Names    EC 2.7.10.1; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog; avian); Epidermal growth factor receptor precursor; ERBB1; kinase EGFR; Receptor protein-tyrosine kinase ErbB-1
 Product Gene Name   

anti-EGFR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 211980
 3D Structure    ModBase 3D Structure for P00533
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    EGFR (Phospho-Ser1071) antibody detects endogenous levels of EGFR only when phosphorylated at serine 1071.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 92%, Positives = 100%); Rat (Identities = 85%, Positives = 85%)
 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human EGFR around the phosphorylation site of serine 1071 (Y-S-SP-D-P).
 All Sites    Human: Ser1071; Mouse: Ser1071; Rat: Ser1071
 Pathway    Phospho-specific
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-EGFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-EGFR antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-EGFR antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-EGFR antibody    WB: 1:500~1:1000, ELISA: 1:5000
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 Testing Data of anti-EGFR antibody    Western blot analysis of extracts from HepG2 cells, treated with serum (20%, 15mins), using EGFR (Phospho-Ser1071) antibody.
anti-EGFR antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for EGFR. It may not necessarily be applicable to this product.
 NCBI GI #    29725609
 NCBI GeneID    1956
 NCBI Accession #    NP_005219.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005228.3 [Other Products]
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 UniProt Primary Accession #    P00533 [Other Products]
 UniProt Secondary Accession #    O00688; O00732; P06268; Q14225; Q68GS5; Q92795; Q9BZS2; Q9GZX1; Q9H2C9; Q9H3C9; Q9UMD7 [Other Products]
 UniProt Related Accession #    P00533 [Other Products]
 Molecular Weight    69,228 Da
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 NCBI Official Full Name    epidermal growth factor receptor isoform a
 NCBI Official Synonym Full Names    epidermal growth factor receptor
 NCBI Official Symbol    EGFR [Similar Products]
 NCBI Official Synonym Symbols   
ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
[Similar Products]
 NCBI Protein Information    epidermal growth factor receptor; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
 UniProt Protein Name    Epidermal growth factor receptor
 UniProt Synonym Protein Names   
Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
 Protein Family    Epidermal growth factor receptor
 UniProt Gene Name    EGFR [Similar Products]
 UniProt Synonym Gene Names    ERBB; ERBB1; HER1 [Similar Products]
 UniProt Entry Name    EGFR_HUMAN
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 NCBI Summary for EGFR    The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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 UniProt Comments for EGFR    EGFR: a receptor tyrosine kinase. This is a receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30, and vaccinia virus growth factor. EGFR is involved in the control of cell growth and differentiation. It is a single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation. It can be phosphorylated and activated by Src. Activated EGFR binds the SH2 domain of phospholipase C-gamma (PLC-gamma), activating PLC-gamma-mediated downstream signaling. Phosphorylated EGFR binds Cbl, leading to its ubiquitination and degradation. Grb2 and SHC bind to phospho-EGFR and are involved in the activation of MAP kinase signaling pathways. Phosphorylation on Ser and Thr residues is thought to represent a mechanism for attenuation of EGFR kinase activity. EGFR is overexpressed in breast, head and neck cancers, correlating with poor survival. Activating somatic mutations are seen in lung cancer, corresponding to the minority of patients with strong responses to the EGFR inhibitor Iressa (gefitinib). Mutations and amplifications are also seen in glioblastoma, and upregulation is seen in colon cancer and neoplasms. In xenografts, inhibitors synergize with cytotoxic drugs in the inhibition of many tumor types. Inhibitors include: Iressa/ZD1839, Erbitux, Tarceva, and lapatinib. Four alternatively spliced isoforms have been described.

Protein type: Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; Protein kinase, TK; Tumor suppressor; EC 2.7.10.1; TK group; EGFR family

Chromosomal Location of Human Ortholog: 7p12

Cellular Component: extracellular space; endoplasmic reticulum membrane; nuclear membrane; focal adhesion; cell surface; basolateral plasma membrane; integral to membrane; lipid raft; Golgi membrane; membrane; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; plasma membrane; AP-2 adaptor complex; endosome membrane; nucleus; receptor complex; endosome

Molecular Function: identical protein binding; epidermal growth factor receptor activity; epidermal growth factor binding; nitric-oxide synthase regulator activity; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; protein phosphatase binding; protein kinase binding; integrin binding; actin filament binding; protein binding; enzyme binding; transmembrane receptor activity; MAP kinase kinase kinase activity; protein heterodimerization activity; protein-tyrosine kinase activity; ubiquitin protein ligase binding; double-stranded DNA binding; chromatin binding; glycoprotein binding; ATP binding

Biological Process: circadian rhythm; diterpenoid metabolic process; positive regulation of nitric oxide biosynthetic process; nerve growth factor receptor signaling pathway; activation of MAPKK activity; alkanesulfonate metabolic process; protein insertion into membrane; positive regulation of vasodilation; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; positive regulation of MAP kinase activity; positive regulation of fibroblast proliferation; cell-cell adhesion; ovulation cycle; cell surface receptor linked signal transduction; hair follicle development; positive regulation of superoxide release; negative regulation of mitotic cell cycle; positive regulation of DNA repair; fibroblast growth factor receptor signaling pathway; digestive tract morphogenesis; response to osmotic stress; phospholipase C activation; response to hydroxyisoflavone; hydrogen peroxide metabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of nitric-oxide synthase activity; response to oxidative stress; negative regulation of protein catabolic process; response to calcium ion; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of epidermal growth factor receptor signaling pathway; tongue development; axon guidance; embryonic placenta development; peptidyl-tyrosine phosphorylation; translation; protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; signal transduction; positive regulation of synaptic transmission, glutamatergic; learning and/or memory; positive regulation of cell proliferation; salivary gland morphogenesis; response to stress; regulation of peptidyl-tyrosine phosphorylation; epidermal growth factor receptor signaling pathway; ossification; phosphoinositide-mediated signaling; MAPKKK cascade; liver development; cell proliferation; positive regulation of protein kinase B signaling cascade; cerebral cortex cell migration; calcium-dependent phospholipase A2 activation; positive regulation of vasoconstriction; innate immune response; positive regulation of protein amino acid phosphorylation; astrocyte activation; positive regulation of DNA replication; response to cobalamin; positive regulation of phosphorylation; positive regulation of cell migration; positive regulation of inflammatory response; lung development

Disease: Lung Cancer
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Product References and Citations for anti-EGFR antibody

   Ullrich A., Nature 309:418-425(1984).
Ilekis J.V., Mol. Reprod. Dev. 41:149-156(1995).
Reiter J.L., Nucleic Acids Res. 24:4050-4056(1996).
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 Research Articles on EGFR    1. A novel role for Ack1 in diverting activated EGFR into a non-canonical degradative pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-EGFR antibodyDiseases associated with anti-EGFR antibody
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >9135 publications with EGFR and Carcinoma
 Lung Neoplasms Antibodies  >5022 publications with EGFR and Lung Neoplasms
 Adenocarcinoma Antibodies  >3780 publications with EGFR and Adenocarcinoma
 Kidney Diseases Antibodies  >3670 publications with EGFR and Kidney Diseases
 Small Cell Lung Carcinoma Antibodies  >3383 publications with EGFR and Small Cell Lung Carcinoma
 Carcinoma, Non-Small-Cell Lung Antibodies  >3344 publications with EGFR and Carcinoma, Non-Small-Cell Lung
 Disease Progression Antibodies  >2864 publications with EGFR and Disease Progression
 Breast Neoplasms Antibodies  >2583 publications with EGFR and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >2459 publications with EGFR and Carcinoma, Squamous Cell
 Head and Neck Neoplasms Antibodies  >1945 publications with EGFR and Head and Neck Neoplasms
Organs/Tissues associated with anti-EGFR antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >6787 publications with EGFR and Lung
 Kidney Antibodies  >5099 publications with EGFR and Kidney
 Vascular Antibodies  >2397 publications with EGFR and Vascular
 Brain Antibodies  >2002 publications with EGFR and Brain
 Liver Antibodies  >1216 publications with EGFR and Liver
 Skin Antibodies  >1168 publications with EGFR and Skin
 Heart Antibodies  >1109 publications with EGFR and Heart
 Muscle Antibodies  >658 publications with EGFR and Muscle
 Prostate Antibodies  >647 publications with EGFR and Prostate
 Bone Antibodies  >489 publications with EGFR and Bone
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