NP_001229395.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
phosphatidylinositol 3-kinase regulatory subunit alpha isoform 4
NCBI Official Synonym Full Names
phosphoinositide-3-kinase regulatory subunit 1
NCBI Official Synonym Symbols
p85; AGM7; GRB1; IMD36; p85-ALPHA [Similar Products]
NCBI Protein Information
phosphatidylinositol 3-kinase regulatory subunit alpha
UniProt Protein Name
Phosphatidylinositol 3-kinase regulatory subunit alpha
UniProt Synonym Protein Names
Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha
UniProt Synonym Gene Names
GRB1; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha [Similar Products]
NCBI Summary for EGFR
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
UniProt Comments for EGFR
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Product References and Citations for anti-EGFR antibody
1. Cantley, L.C. (2002) Science 296, 1655-7. 2. Simpson, L. and Parsons, R. (2001) Exp Cell Res 264, 29-41. 3. Neri, L.M. et al. (2002) Biochim Biophys Acta 1584, 73-80. 4. Stoyanov, B. et al. (1995) Science 269, 690-3.
Research Articles on EGFR
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Pathways associated with anti-EGFR antibody
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Organs/Tissues associated with anti-EGFR antibody
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