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anti-EPHA2/3 antibody :: anti-Human, Mouse EPHA2/3 Antibody

Scan QR to view Datasheet Catalog #    MBS854845
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EPHA2/3, Antibody

★Popular Item★
 Also Known As   

EPHA2/3 (Phospho-Tyr588/596) Antibody

 Product Synonym Names    EC 2.7.10.1; ECK; Ephrin type-A receptor 2 precursor; Epithelial cell kinase; MPK-5; SEK-2; SEK2; Tyrosine-protein kinase receptor ECK; kinase EphA2
 Product Gene Name   

anti-EPHA2/3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    116600
 3D Structure    ModBase 3D Structure for P29317
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 Species Reactivity    Human, Mouse
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 Specificity    EPHA2/3/4 (Phospho-Tyr588/596) antibody detects endogenous levels of EPHA2/3/4 only when phosphorylated at tyrosine 588/596.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human EPHA2/3/4 around the phosphorylation site of tyrosine 588/596 (T-YP-V-D-P).
 All Sites    Human: Tyr588/Tyr596/Tyr596
Mouse: Tyr589/Tyr596/Tyr596
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-EPHA2/3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-EPHA2/3 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-EPHA2/3 antibody   

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-EPHA2/3 antibody    WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:20000
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 Testing Data of anti-EPHA2/3 antibody    anti-EPHA2/3 antibody Testing Data image
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 Western Blot (WB) of anti-EPHA2/3 antibody    P-peptide-+ Western blot analysis of extracts from HepG2 cells, using EPHA2/3/4 (Phospho-Tyr588/596) antibody. Immunofluorescence analysis of HeLa cells, using EPHA2/3/4 (Phospho-Tyr588/596) antibody.
anti-EPHA2/3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for EPHA2/3. It may not necessarily be applicable to this product.
 NCBI GI #    32967311
 NCBI GeneID    1969
 NCBI Accession #    NP_004422.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004431.4 [Other Products]
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 UniProt Primary Accession #    P29317 [Other Products]
 UniProt Secondary Accession #    Q8N3Z2; B5A968 [Other Products]
 UniProt Related Accession #    P29317 [Other Products]
 Molecular Weight    54,305 Da
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 NCBI Official Full Name    ephrin type-A receptor 2 isoform 1
 NCBI Official Synonym Full Names    EPH receptor A2
 NCBI Official Symbol    EPHA2 [Similar Products]
 NCBI Official Synonym Symbols   
ECK; CTPA; ARCC2; CTPP1; CTRCT6
[Similar Products]
 NCBI Protein Information    ephrin type-A receptor 2
 UniProt Protein Name    Ephrin type-A receptor 2
 UniProt Synonym Protein Names   
Epithelial cell kinase; Tyrosine-protein kinase receptor ECK
 UniProt Gene Name    EPHA2 [Similar Products]
 UniProt Synonym Gene Names    ECK [Similar Products]
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 NCBI Summary for EPHA2/3    This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
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 UniProt Comments for EPHA2/3    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
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Product References and Citations for anti-EPHA2/3 antibody

   Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990). Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005). Zhuang G., J. Biol. Chem. 282:2683-2694(2007).
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 Research Articles on EPHA2/3    1. These observations demonstrate that EphA2 affects the sensitivity to oxaliplatin by inducing EMT in oxaliplatin-resistant gastric cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EPHA2/3 antibodyPathways associated with anti-EPHA2/3 antibody
 Reference Product  PubMed Publications
 EGFR antibody  >22 publications with EPHA2/3 and EGFR
 EFNA1 antibody  >11 publications with EPHA2/3 and EFNA1
 PTK2 antibody  >10 publications with EPHA2/3 and PTK2
 CBL antibody  >7 publications with EPHA2/3 and CBL
 GRB2 antibody  >5 publications with EPHA2/3 and GRB2
 ACP1 antibody  >4 publications with EPHA2/3 and ACP1
 EFNA5 antibody  >2 publications with EPHA2/3 and EFNA5
 EFNA4 antibody  >2 publications with EPHA2/3 and EFNA4
 SLA antibody  >2 publications with EPHA2/3 and SLA
 CLDN4 antibody  >1 publications with EPHA2/3 and CLDN4
 Products by Pathway  Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 EPHA2 Forward Signaling Pathway antibodies  EPHA2 Forward Signaling Pathway Diagram
 EphrinA-EPHA Pathway antibodies  EphrinA-EPHA Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Stabilization And Expansion Of The E-cadherin Adherens Junction Pathway antibodies  Stabilization And Expansion Of The E-cadherin Adherens Junction Pathway Diagram
Diseases associated with anti-EPHA2/3 antibodyOrgans/Tissues associated with anti-EPHA2/3 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >269 publications with EPHA2/3 and Neoplasms
 Breast Neoplasms Antibodies  >56 publications with EPHA2/3 and Breast Neoplasms
 Lung Neoplasms Antibodies  >31 publications with EPHA2/3 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >29 publications with EPHA2/3 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >29 publications with EPHA2/3 and Ovarian Neoplasms
 Disease Models, Animal Antibodies  >26 publications with EPHA2/3 and Disease Models, Animal
 Nervous System Diseases Antibodies  >23 publications with EPHA2/3 and Nervous System Diseases
 Lung Diseases Antibodies  >22 publications with EPHA2/3 and Lung Diseases
 Brain Diseases Antibodies  >22 publications with EPHA2/3 and Brain Diseases
 Carcinoma, Squamous Cell Antibodies  >21 publications with EPHA2/3 and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >79 publications with EPHA2/3 and Vascular
 Brain Antibodies  >56 publications with EPHA2/3 and Brain
 Lung Antibodies  >53 publications with EPHA2/3 and Lung
 Prostate Antibodies  >36 publications with EPHA2/3 and Prostate
 Eye Antibodies  >26 publications with EPHA2/3 and Eye
 Embryonic Tissue Antibodies  >24 publications with EPHA2/3 and Embryonic Tissue
 Lymph Node Antibodies  >24 publications with EPHA2/3 and Lymph Node
 Liver Antibodies  >23 publications with EPHA2/3 and Liver
 Kidney Antibodies  >15 publications with EPHA2/3 and Kidney
 Skin Antibodies  >15 publications with EPHA2/3 and Skin
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