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anti-EPHA4 antibody :: anti-Human, Mouse EPHA4 Antibody

Scan QR to view Datasheet Catalog #    MBS854677
Western Blot (WB)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EPHA4, Antibody

★Popular Item★
 Also Known As   

EPHA4 (Phospho-Tyr596) Antibody

 Product Synonym Names    Ephrin type-A receptor 4; EC=2.7.10.1; EPH-like kinase 8; EK8; hEK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK
 Product Gene Name   

anti-EPHA4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602188
 3D Structure    ModBase 3D Structure for P54764
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 Species Reactivity    Human, Mouse
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 Specificity    EPHA4 (Phospho-Tyr596) antibody detects endogenous levels of EPHA4 only when phosphorylated at tyrosine 596
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human EPHA4 around the phosphorylation site of tyrosine 596.
 All Sites    Human: Tyr596
Mouse: Tyr596
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-EPHA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-EPHA4 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-EPHA4 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-EPHA4 antibody    WB: 1:500~1:1000
ELISA: 1:20000
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 Western Blot (WB) of anti-EPHA4 antibody    Western blot analysis of extracts from JurKat cells, using EPHA4 (Phospho-Tyr596) antibody.
anti-EPHA4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for EPHA4. It may not necessarily be applicable to this product.
 NCBI GI #    751557656
 NCBI GeneID    2043
 NCBI Accession #    NP_001291465.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001304536.1 [Other Products]
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 UniProt Primary Accession #    P54764 [Other Products]
 UniProt Secondary Accession #    Q2M380; A8K2P1; B2R601; B7Z6Q8 [Other Products]
 UniProt Related Accession #    P54764 [Other Products]
 Molecular Weight    104,507 Da
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 NCBI Official Full Name    ephrin type-A receptor 4 isoform a
 NCBI Official Synonym Full Names    EPH receptor A4
 NCBI Official Symbol    EPHA4 [Similar Products]
 NCBI Official Synonym Symbols   
SEK; HEK8; TYRO1
[Similar Products]
 NCBI Protein Information    ephrin type-A receptor 4
 UniProt Protein Name    Ephrin type-A receptor 4
 UniProt Synonym Protein Names   
EPH-like kinase 8; EK8; hEK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK
 Protein Family    Ephrin type-A receptor
 UniProt Gene Name    EPHA4 [Similar Products]
 UniProt Synonym Gene Names    HEK8; SEK; TYRO1; EK8; hEK8 [Similar Products]
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 NCBI Summary for EPHA4    This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
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 UniProt Comments for EPHA4    Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.
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Product References and Citations for anti-EPHA4 antibody

   Rikova K., Cell 131:1190-1203(2007) [PubMed: 18083107]. Richter M., J. Neurosci. 27:14205-14215(2007) [PubMed: 18094260]. Fu W.Y., Nat. Neurosci. 10:67-76(2007) [PubMed: 17143272].
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 Research Articles on EPHA4    1. High erythropoietin-producing hepatocellular carcinoma receptor A (EphA) 1, 2, and 4 expression levels were significantly related to recurrence.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EPHA4 antibodyPathways associated with anti-EPHA4 antibody
 Reference Product  PubMed Publications
 EFNB3 antibody  >32 publications with EPHA4 and EFNB3
 EFNB1 antibody  >5 publications with EPHA4 and EFNB1
 EFNB2 antibody  >5 publications with EPHA4 and EFNB2
 NGEF antibody  >4 publications with EPHA4 and NGEF
 EFNA3 antibody  >3 publications with EPHA4 and EFNA3
 EFNA4 antibody  >2 publications with EPHA4 and EFNA4
 EFNA2 antibody  >2 publications with EPHA4 and EFNA2
 EFNA5 antibody  >1 publications with EPHA4 and EFNA5
 EFNA1 antibody  >1 publications with EPHA4 and EFNA1
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPH-ephrin Mediated Repulsion Of Cells Pathway antibodies  EPH-ephrin Mediated Repulsion Of Cells Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 EPHA-mediated Growth Cone Collapse Pathway antibodies  EPHA-mediated Growth Cone Collapse Pathway Diagram
 EphrinA-EPHA Pathway antibodies  EphrinA-EPHA Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
Diseases associated with anti-EPHA4 antibodyOrgans/Tissues associated with anti-EPHA4 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >17 publications with EPHA4 and Disease Models, Animal
 Embryo Loss Antibodies  >11 publications with EPHA4 and Embryo Loss
 Inflammation Antibodies  >11 publications with EPHA4 and Inflammation
 Immune System Diseases Antibodies  >8 publications with EPHA4 and Immune System Diseases
 Adenocarcinoma Antibodies  >8 publications with EPHA4 and Adenocarcinoma
 Atherosclerosis Antibodies  >6 publications with EPHA4 and Atherosclerosis
 Necrosis Antibodies  >6 publications with EPHA4 and Necrosis
 Prostatic Neoplasms Antibodies  >4 publications with EPHA4 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >4 publications with EPHA4 and Breast Neoplasms
 Heart Diseases Antibodies  >4 publications with EPHA4 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >203 publications with EPHA4 and Brain
 Embryonic Tissue Antibodies  >66 publications with EPHA4 and Embryonic Tissue
 Blood Antibodies  >38 publications with EPHA4 and Blood
 Muscle Antibodies  >33 publications with EPHA4 and Muscle
 Eye Antibodies  >32 publications with EPHA4 and Eye
 Bone Antibodies  >25 publications with EPHA4 and Bone
 Vascular Antibodies  >24 publications with EPHA4 and Vascular
 Skin Antibodies  >11 publications with EPHA4 and Skin
 Heart Antibodies  >11 publications with EPHA4 and Heart
 Kidney Antibodies  >10 publications with EPHA4 and Kidney
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