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anti-EPO antibody :: Mouse anti-Human EPO Antibody

Scan QR to view Datasheet Catalog #    MBS850677
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EPO, Antibody

 Also Known As   

EPO Antibody

 Product Synonym Names    EP; MVCD2; MGC138142; EPO
 Product Gene Name   

anti-EPO antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    133170
 3D Structure    ModBase 3D Structure for P01588
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 Isotype    IgG1
 Clone Number    4F11
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of human EPO expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C.
 Other Notes    Small volumes of anti-EPO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-EPO antibody

   Human erythropoietin is member of the EPO/TPO family and encodes a secreted, glycosylated cytokine hormone composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.
 Product Categories/Family for anti-EPO antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-EPO antibody   

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-EPO antibody    WB: 1:500-1:2000
IF: 1:200-1:1000
ELISA: 1:10000
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 Western Blot (WB) of anti-EPO antibody    Figure 1: Western blot analysis using EPO mAb against HEK293 (1) and EPO-hIgGFc transfected HEK293 (2) cell lysate.
anti-EPO antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-EPO antibody    Figure 2: Immunofluorescence analysis of GC7901 cells using EPO mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
anti-EPO antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for EPO. It may not necessarily be applicable to this product.
 NCBI GI #    62240997
 NCBI GeneID    2056
 NCBI Accession #    NP_000790.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000799.3 [Other Products]
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 UniProt Primary Accession #    P01588 [Other Products]
 UniProt Secondary Accession #    Q2M2L6; Q549U2; Q9UDZ0; Q9UEZ5; Q9UHA0 [Other Products]
 UniProt Related Accession #    P01588 [Other Products]
 Molecular Weight    21kDa
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 NCBI Official Full Name    erythropoietin
 NCBI Official Synonym Full Names    erythropoietin
 NCBI Official Symbol    EPO [Similar Products]
 NCBI Official Synonym Symbols   
EP; DBAL; ECYT5; MVCD2
[Similar Products]
 NCBI Protein Information    erythropoietin
 UniProt Protein Name    Erythropoietin
 UniProt Synonym Protein Names   
INN: Epoetin
 Protein Family    Erythropoietin
 UniProt Gene Name    EPO [Similar Products]
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 NCBI Summary for EPO    This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017]
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 UniProt Comments for EPO    Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
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 Research Articles on EPO    1. Circulating anti-EPO are detected in a significant proportion of treatment-naive HCV-infected patients and are independently associated with anemia, suggesting a further implication of autoimmunity in the pathophysiology of HCV-related anemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EPO antibodyPathways associated with anti-EPO antibody
 Reference Product  PubMed Publications
 EPOR antibody  >727 publications with EPO and EPOR
 JAK2 antibody  >326 publications with EPO and JAK2
 TNF antibody  >285 publications with EPO and TNF
 HIF1A antibody  >260 publications with EPO and HIF1A
 STAT3 antibody  >81 publications with EPO and STAT3
 VEGFA antibody  >47 publications with EPO and VEGFA
 GATA2 antibody  >28 publications with EPO and GATA2
 TFRC antibody  >4 publications with EPO and TFRC
 Products by Pathway  Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 EPO Signaling Pathway antibodies  EPO Signaling Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HIF-2-alpha Transcription Factor Network Pathway antibodies  HIF-2-alpha Transcription Factor Network Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
Diseases associated with anti-EPO antibodyOrgans/Tissues associated with anti-EPO antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >2805 publications with EPO and Anemia
 Kidney Diseases Antibodies  >1371 publications with EPO and Kidney Diseases
 Renal Insufficiency Antibodies  >1006 publications with EPO and Renal Insufficiency
 Kidney Failure, Chronic Antibodies  >926 publications with EPO and Kidney Failure, Chronic
 Vascular Diseases Antibodies  >885 publications with EPO and Vascular Diseases
 Nervous System Diseases Antibodies  >692 publications with EPO and Nervous System Diseases
 Inflammation Antibodies  >593 publications with EPO and Inflammation
 Central Nervous System Diseases Antibodies  >520 publications with EPO and Central Nervous System Diseases
 Necrosis Antibodies  >368 publications with EPO and Necrosis
 Heart Diseases Antibodies  >366 publications with EPO and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >809 publications with EPO and Brain
 Eye Antibodies  >159 publications with EPO and Eye
 Testis Antibodies  >33 publications with EPO and Testis
 Prostate Antibodies  >32 publications with EPO and Prostate
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