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anti-ERI1 antibody :: Rabbit ERI1 Antibody

Scan QR to view Datasheet Catalog #    MBS003429 anti-ERI1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ERI1, Antibody

 Also Known As   

Rabbit ERI1 Antibody

 Product Gene Name   

anti-ERI1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 8; NC_000008.10 (8860314..8890849). Location: 8p23.1
 OMIM    608739
 3D Structure    ModBase 3D Structure for Q8IV48
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-ERI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ERI1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ERI1. It may not necessarily be applicable to this product.
 NCBI GI #    31543184
 NCBI GeneID    90459
 NCBI Accession #    NP_699163.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_153332.3 [Other Products]
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 UniProt Primary Accession #    Q8IV48 [Other Products]
 UniProt Secondary Accession #    Q9NSX3; A8K4U7 [Other Products]
 UniProt Related Accession #    Q8IV48 [Other Products]
 Molecular Weight    40,064 Da
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 NCBI Official Full Name    3'-5' exoribonuclease 1
 NCBI Official Synonym Full Names    exoribonuclease 1
 NCBI Official Symbol    ERI1 [Similar Products]
 NCBI Official Synonym Symbols   
HEXO; THEX1; 3'HEXO
[Similar Products]
 NCBI Protein Information    3'-5' exoribonuclease 1; Eri-1 homolog; protein 3'hExo; 3' exoribonuclease; 3'-5' exonuclease ERI1; histone mRNA 3'-exonuclease 1; three prime mRNA exonuclease 1; three prime histone mRNA exonuclease 1; histone mRNA 3' end-specific exonuclease; histone mRNA 3'-end-specific exoribonuclease; enhanced RNAi three prime mRNA exonuclease homolog 1
 UniProt Protein Name    3'-5' exoribonuclease 1
 UniProt Synonym Protein Names   
3'-5' exonuclease ERI1; Eri-1 homolog; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; Protein 3'hExo
 Protein Family    ERI1 exoribonuclease
 UniProt Gene Name    ERI1 [Similar Products]
 UniProt Synonym Gene Names    3'EXO; THEX1; HEXO [Similar Products]
 UniProt Entry Name    ERI1_HUMAN
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 UniProt Comments for ERI1    THEX1: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs. Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Interacts in a cooperative manner with SLBP to the mature 3'-end of histone mRNAs. Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the stem-loop structure of the 3'-end of histone mRNAs. Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity.

Protein type: Hydrolase; EC 3.1.-.-; Nucleolus

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function: rRNA binding; 3'-5'-exoribonuclease activity; metal ion binding; ribosome binding; 3'-5' exonuclease activity

Biological Process: RNA-mediated gene silencing; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA 3'-end processing
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 Research Articles on ERI1    1. the crystal structure of a ternary complex of human SLBP RNA binding domain, human 3'hExo, and a 26-nucleotide stem-loop RNA is reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ERI1 antibodyOrgans/Tissues associated with anti-ERI1 antibody
 Disease Name  Pubmed Publications
 Hepatitis Antibodies  >1 publications with ERI1 and Hepatitis
 Disease Models, Animal Antibodies  >1 publications with ERI1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with ERI1 and Blood
 Bone Marrow Antibodies  >1 publications with ERI1 and Bone Marrow
 Bone Antibodies  >1 publications with ERI1 and Bone
 Brain Antibodies  >1 publications with ERI1 and Brain
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