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anti-ERN1 antibody :: Mouse anti-Human ERN1 Antibody

Scan QR to view Datasheet Catalog #    MBS850823
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ERN1, Antibody

 Also Known As   

ERN1 Antibody

 Product Synonym Names    IRE1; IRE1P; IRE1a; hIRE1p; FLJ30999; MGC163277; MGC163279; ERN1
 Product Gene Name   

anti-ERN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604033
 3D Structure    ModBase 3D Structure for O75460
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 Isotype    IgG1
 Clone Number    9F2
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of human ERN1(aa282-433) expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C.
 Other Notes    Small volumes of anti-ERN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ERN1 antibody

   The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.
 Product Categories/Family for anti-ERN1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-ERN1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-ERN1 antibody    WB: 1:500-1:2000
IHC: 1:200-1:1000
ELISA: 1:10000
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 Western Blot (WB) of anti-ERN1 antibody    Figure 1: Western blot analysis using ERN1 mouse mAb against Raji (1), A431 (2), Jurkat (3), Hela(4) and HEK293 (5) cell lysate.
anti-ERN1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ERN1 antibody    Figure 2: Immunohistochemical analysis of paraffin-embedded human brain tissue (A) and stomach tissue (B), showing cytoplasmic localization using ERN1 mouse mAb with DAB staining.
anti-ERN1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ERN1 antibody    Figure 3: Immunohistochemical analysis of paraffin-embedded human Placenta tissues using ERN1 mouse mAb
anti-ERN1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ERN1. It may not necessarily be applicable to this product.
 NCBI GI #    153946421
 NCBI GeneID    2081
 NCBI Accession #    NP_001424.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001433.4 [Other Products]
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 UniProt Primary Accession #    O75460 [Other Products]
 UniProt Secondary Accession #    Q59EE2; A1L457; A8K8N8; A8MXS7 [Other Products]
 UniProt Related Accession #    O75460 [Other Products]
 Molecular Weight    109kDa
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 NCBI Official Full Name    serine/threonine-protein kinase/endoribonuclease IRE1
 NCBI Official Synonym Full Names    endoplasmic reticulum to nucleus signaling 1
 NCBI Official Symbol    ERN1 [Similar Products]
 NCBI Official Synonym Symbols   
IRE1; IRE1P; IRE1a; hIRE1p
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase/endoribonuclease IRE1
 UniProt Protein Name    Serine/threonine-protein kinase/endoribonuclease IRE1
 UniProt Synonym Protein Names   
Endoplasmic reticulum-to-nucleus signaling 1
 UniProt Gene Name    ERN1 [Similar Products]
 UniProt Synonym Gene Names    IRE1a [Similar Products]
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 NCBI Summary for ERN1    This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
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 UniProt Comments for ERN1    Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875).
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 Research Articles on ERN1    1. Three branches of the Unfolded Protein Response (UPR) have been described, including the activation of the inositol-requiring enzyme 1 (IRE1), the pancreatic ER kinase (PKR)-like ER kinase (PERK), and the activating transcription factor 6 (ATF6).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ERN1 antibodyPathways associated with anti-ERN1 antibody
 Reference Product  PubMed Publications
 XBP1 antibody  >78 publications with ERN1 and XBP1
 ATF6 antibody  >52 publications with ERN1 and ATF6
 JUN antibody  >36 publications with ERN1 and JUN
 TRAF2 antibody  >10 publications with ERN1 and TRAF2
 HSPA5 antibody  >8 publications with ERN1 and HSPA5
 TMBIM6 antibody  >7 publications with ERN1 and TMBIM6
 SYVN1 antibody  >2 publications with ERN1 and SYVN1
 VEGFA antibody  >1 publications with ERN1 and VEGFA
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
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 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 IRE1alpha Activates Chaperones Pathway antibodies  IRE1alpha Activates Chaperones Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with anti-ERN1 antibodyOrgans/Tissues associated with anti-ERN1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >23 publications with ERN1 and Inflammation
 Insulin Resistance Antibodies  >14 publications with ERN1 and Insulin Resistance
 Liver Diseases Antibodies  >14 publications with ERN1 and Liver Diseases
 Nervous System Diseases Antibodies  >14 publications with ERN1 and Nervous System Diseases
 Fatty Liver Antibodies  >11 publications with ERN1 and Fatty Liver
 Brain Diseases Antibodies  >11 publications with ERN1 and Brain Diseases
 Necrosis Antibodies  >10 publications with ERN1 and Necrosis
 Breast Neoplasms Antibodies  >6 publications with ERN1 and Breast Neoplasms
 Hyperglycemia Antibodies  >6 publications with ERN1 and Hyperglycemia
 Disease Models, Animal Antibodies  >6 publications with ERN1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >31 publications with ERN1 and Liver
 Blood Antibodies  >22 publications with ERN1 and Blood
 Pancreas Antibodies  >16 publications with ERN1 and Pancreas
 Nerve Antibodies  >8 publications with ERN1 and Nerve
 Eye Antibodies  >6 publications with ERN1 and Eye
 Kidney Antibodies  >5 publications with ERN1 and Kidney
 Prostate Antibodies  >5 publications with ERN1 and Prostate
 Lung Antibodies  >4 publications with ERN1 and Lung
 Mixed Antibodies  >1 publications with ERN1 and Mixed
 Testis Antibodies  >1 publications with ERN1 and Testis
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