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anti-EphA1 antibody :: Mouse anti-Human EphA1 Antibody

Scan QR to view Datasheet Catalog #    MBS850785
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EphA1, Antibody

 Also Known As   

EphA1 Antibody

 Product Synonym Names    EPH; EPHT; EPHT1
 Product Gene Name   

anti-EphA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    179610
 3D Structure    ModBase 3D Structure for P21709
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 Isotype    IgG1
 Clone Number    5D2
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Purified antibody in PBS containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of EphA1 expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C
 Other Notes    Small volumes of anti-EphA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-EphA1 antibody

   EPH receptor A1 (EphA1), with 976-amino acid protein(about 107 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date and their ligands, the ephrins, can be subdivided into two major subclasses, ephrin-A and ephrin-B. Interaction of Eph receptor tyrosine kinases with their membrane bound ephrin ligands initiates bidirectional signaling events that regulate cell migratory and adhesive behavior, particularly in the nervous system. They have been implicated in various developmental processes, including axonal guidance, angiogenesis, morphogenesis and carcinogenesis.
 Product Categories/Family for anti-EphA1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-EphA1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-EphA1 antibody    WB: 1:500-1:2000
IHC: 1:200-1:1000
ELISA: 1:10000
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 Western Blot (WB) of anti-EphA1 antibody    Figure 1. Western blot analysis using EphA1 mouse mAb against A549 (1) and Hela (2) cell lysate.
anti-EphA1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-EphA1 antibody    Figure 2. Immunohistochemical analysis of paraffin-embedded human ovary carcinoma (left) and breast carcinoma (right), showing cytoplasmic localization using EphA1 mouse mAb with DAB staining.
anti-EphA1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for EphA1. It may not necessarily be applicable to this product.
 NCBI GI #    221316650
 NCBI GeneID    2041
 NCBI Accession #    NP_005223.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_005232.4 [Other Products]
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 UniProt Primary Accession #    P21709 [Other Products]
 UniProt Secondary Accession #    Q15405; A1L3V3; B5A966; B5A967 [Other Products]
 UniProt Related Accession #    P21709 [Other Products]
 Molecular Weight    108kDa
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 NCBI Official Full Name    ephrin type-A receptor 1
 NCBI Official Synonym Full Names    EPH receptor A1
 NCBI Official Symbol    EPHA1 [Similar Products]
 NCBI Official Synonym Symbols   
EPH; EPHT; EPHT1
[Similar Products]
 NCBI Protein Information    ephrin type-A receptor 1
 UniProt Protein Name    Ephrin type-A receptor 1
 UniProt Synonym Protein Names   
EPH tyrosine kinase; EPH tyrosine kinase 1; Erythropoietin-producing hepatoma receptor; Tyrosine-protein kinase receptor EPH
 Protein Family    Ephrin type-A receptor
 UniProt Gene Name    EPHA1 [Similar Products]
 UniProt Synonym Gene Names    EPH; EPHT; EPHT1; hEpha1 [Similar Products]
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 NCBI Summary for EphA1    This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EphA1    Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
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 Research Articles on EphA1    1. High erythropoietin-producing hepatocellular carcinoma receptor A (EphA) 1, 2, and 4 expression levels were significantly related to recurrence.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EphA1 antibodyPathways associated with anti-EphA1 antibody
 Reference Product  PubMed Publications
 EFNA1 antibody  >3 publications with EphA1 and EFNA1
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
Diseases associated with anti-EphA1 antibodyOrgans/Tissues associated with anti-EphA1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with EphA1 and Neoplasms
 Alzheimer Disease Antibodies  >14 publications with EphA1 and Alzheimer Disease
 Neurodegenerative Diseases Antibodies  >13 publications with EphA1 and Neurodegenerative Diseases
 Colorectal Neoplasms Antibodies  >6 publications with EphA1 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >6 publications with EphA1 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >4 publications with EphA1 and Carcinoma, Squamous Cell
 Prostatic Neoplasms Antibodies  >4 publications with EphA1 and Prostatic Neoplasms
 Inflammation Antibodies  >4 publications with EphA1 and Inflammation
 Neoplasm Invasiveness Antibodies  >4 publications with EphA1 and Neoplasm Invasiveness
 Cell Transformation, Neoplastic Antibodies  >3 publications with EphA1 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >29 publications with EphA1 and Brain
 Blood Antibodies  >19 publications with EphA1 and Blood
 Embryonic Tissue Antibodies  >11 publications with EphA1 and Embryonic Tissue
 Lung Antibodies  >8 publications with EphA1 and Lung
 Lymph Node Antibodies  >5 publications with EphA1 and Lymph Node
 Liver Antibodies  >5 publications with EphA1 and Liver
 Thymus Antibodies  >3 publications with EphA1 and Thymus
 Testis Antibodies  >2 publications with EphA1 and Testis
 Pancreas Antibodies  >2 publications with EphA1 and Pancreas
 Thyroid Antibodies  >1 publications with EphA1 and Thyroid
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