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anti-MAPK1/ERK2, MAPK3/ERK1 antibody :: Rabbit anti-Human Erk1/2-T202/Y204 Antibody

Scan QR to view Datasheet Catalog #    MBS9127838
Western Blot (WB)
Unit / Price
0.05 mL  /  $265 +1 FREE 8GB USB
0.1 mL  /  $380 +1 FREE 8GB USB
0.2 mL  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Erk1/2-T202/Y204 (MAPK1/ERK2, MAPK3/ERK1), Antibody

★Popular Item★
 Also Known As   

Phospho-Erk1/2-T202/Y204 Polyclonal Antibody

 Product Synonym Names    Phospho-ERK1/2-T202/Y204: ERK; p38; p40; p41; ERK2; ERT1; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk
 Product Gene Name   

anti-MAPK1/ERK2, MAPK3/ERK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601795
 3D Structure    ModBase 3D Structure for P27361
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Route    Synthetic Peptide
 Immunogen    A phospho specific peptide corresponding to residues surrounding T202/Y204 of human Erk1/2
 Calculated Molecular Weight    42,44KD
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-MAPK1/ERK2, MAPK3/ERK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MAPK1/ERK2, MAPK3/ERK1 antibody

   The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
 Product Categories/Family for anti-MAPK1/ERK2, MAPK3/ERK1 antibody    Phosphorylation
 Applications Tested/Suitable for anti-MAPK1/ERK2, MAPK3/ERK1 antibody   

Western Blot (WB)

 Application Notes for anti-MAPK1/ERK2, MAPK3/ERK1 antibody    WB: 1:500 - 1:2000
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 Western Blot (WB) of anti-MAPK1/ERK2, MAPK3/ERK1 antibody    Western blot analysis of extracts of Jurkat cells, using Phospho-ERK1-T202/Y204 + ERK2-T185/Y187 antibody at 1:2000 dilution. Jurkat cells were treated by PMA/TPA (200nM) for 10 minutes.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% BSA.
Detection: ECL Basic Kit.
Exposure time: 5s.
anti-MAPK1/ERK2, MAPK3/ERK1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MAPK1/ERK2, MAPK3/ERK1. It may not necessarily be applicable to this product.
 NCBI GI #    232066
 NCBI GeneID    5595
 NCBI Accession #    P27361.4 [Other Products]
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 UniProt Primary Accession #    P27361 [Other Products]
 UniProt Secondary Accession #    Q8NHX1; A8CZ58; B0LPG3 [Other Products]
 UniProt Related Accession #    P27361 [Other Products]
 Molecular Weight    40,088 Da
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 NCBI Official Full Name    Mitogen-activated protein kinase 3
 NCBI Official Synonym Full Names    mitogen-activated protein kinase 3
 NCBI Official Symbol    MAPK3 [Similar Products]
 NCBI Official Synonym Symbols   
ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase 3; MAPK 1; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase
 UniProt Protein Name    Mitogen-activated protein kinase 3
 UniProt Synonym Protein Names   
ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1
 UniProt Gene Name    MAPK3 [Similar Products]
 UniProt Synonym Gene Names    ERK1; PRKM3; MAP kinase 3; MAPK 3; ERK-1; p44-MAPK [Similar Products]
 UniProt Entry Name    MK03_HUMAN
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 NCBI Summary for MAPK1/ERK2, MAPK3/ERK1    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAPK1/ERK2, MAPK3/ERK1    ERK1: a serine/threonine kinase of the GMGC group that plays a critical role in the regulation of cell growth and differentiation. ERK1 (MAPK3) and ERK2 (MAPK1) play central roles in MAPK cascades and are activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Depending on the cellular context, MAPK cascades mediate diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. MAPK cascades also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by upstream MAP kinase kinases, MEK1 and -2. Phosphorylation of both the threonine and tyrosine are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates.

Protein type: Protein kinase, CMGC; EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: Golgi apparatus; focal adhesion; mitochondrion; early endosome; nuclear envelope; caveola; pseudopodium; cytosol; microtubule cytoskeleton; nucleoplasm; cytoskeleton; late endosome; nucleus

Molecular Function: MAP kinase activity; protein binding; phosphotyrosine binding; ATP binding; phosphatase binding

Biological Process: axon guidance; viral reproduction; activation of MAPKK activity; positive regulation of histone phosphorylation; nerve growth factor receptor signaling pathway; DNA damage induced protein phosphorylation; activation of MAPK activity; apoptosis; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; sensory perception of pain; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; BMP signaling pathway; toll-like receptor 5 signaling pathway; response to exogenous dsRNA; regulation of transcription factor activity; small GTPase mediated signal transduction; lipopolysaccharide-mediated signaling pathway; toll-like receptor 4 signaling pathway; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; cytokine and chemokine mediated signaling pathway; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; transcription from RNA polymerase I promoter; cell cycle; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of stress-activated MAPK cascade; organ morphogenesis; cartilage development; Ras protein signal transduction; insulin receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of histone acetylation; gene expression; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; toll-like receptor 9 signaling pathway; transcription initiation from RNA polymerase I promoter; vascular endothelial growth factor receptor signaling pathway; blood coagulation; phosphorylation; regulation of cytoskeleton organization and biogenesis
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 Research Articles on MAPK1/ERK2, MAPK3/ERK1    1. ERK, AKT, and GSK-3beta have roles in boldine-induced cell cycle arrest and apoptosis in T24 human bladder cancer cell line
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAPK1/ERK2, MAPK3/ERK1 antibodyPathways associated with anti-MAPK1/ERK2, MAPK3/ERK1 antibody
 Reference Product  PubMed Publications
 MAP2K1 antibody  >364 publications with MAPK1/ERK2, MAPK3/ERK1 and MAP2K1
 MAP2K2 antibody  >153 publications with MAPK1/ERK2, MAPK3/ERK1 and MAP2K2
 ELK1 antibody  >109 publications with MAPK1/ERK2, MAPK3/ERK1 and ELK1
 DUSP1 antibody  >98 publications with MAPK1/ERK2, MAPK3/ERK1 and DUSP1
 CREB1 antibody  >34 publications with MAPK1/ERK2, MAPK3/ERK1 and CREB1
 DUSP6 antibody  >33 publications with MAPK1/ERK2, MAPK3/ERK1 and DUSP6
 DUSP4 antibody  >12 publications with MAPK1/ERK2, MAPK3/ERK1 and DUSP4
 PTPN7 antibody  >5 publications with MAPK1/ERK2, MAPK3/ERK1 and PTPN7
 PTPRR antibody  >2 publications with MAPK1/ERK2, MAPK3/ERK1 and PTPRR
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 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
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 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
Diseases associated with anti-MAPK1/ERK2, MAPK3/ERK1 antibodyOrgans/Tissues associated with anti-MAPK1/ERK2, MAPK3/ERK1 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >771 publications with MAPK1/ERK2, MAPK3/ERK1 and Necrosis
 Cardiovascular Diseases Antibodies  >737 publications with MAPK1/ERK2, MAPK3/ERK1 and Cardiovascular Diseases
 Inflammation Antibodies  >737 publications with MAPK1/ERK2, MAPK3/ERK1 and Inflammation
 Nervous System Diseases Antibodies  >545 publications with MAPK1/ERK2, MAPK3/ERK1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >383 publications with MAPK1/ERK2, MAPK3/ERK1 and Breast Neoplasms
 Heart Diseases Antibodies  >308 publications with MAPK1/ERK2, MAPK3/ERK1 and Heart Diseases
 Hypertension Antibodies  >253 publications with MAPK1/ERK2, MAPK3/ERK1 and Hypertension
 Hypertrophy Antibodies  >246 publications with MAPK1/ERK2, MAPK3/ERK1 and Hypertrophy
 Liver Diseases Antibodies  >231 publications with MAPK1/ERK2, MAPK3/ERK1 and Liver Diseases
 Fibrosis Antibodies  >228 publications with MAPK1/ERK2, MAPK3/ERK1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1682 publications with MAPK1/ERK2, MAPK3/ERK1 and Vascular
 Blood Antibodies  >1615 publications with MAPK1/ERK2, MAPK3/ERK1 and Blood
 Muscle Antibodies  >1520 publications with MAPK1/ERK2, MAPK3/ERK1 and Muscle
 Brain Antibodies  >1208 publications with MAPK1/ERK2, MAPK3/ERK1 and Brain
 Heart Antibodies  >689 publications with MAPK1/ERK2, MAPK3/ERK1 and Heart
 Lung Antibodies  >613 publications with MAPK1/ERK2, MAPK3/ERK1 and Lung
 Bone Antibodies  >522 publications with MAPK1/ERK2, MAPK3/ERK1 and Bone
 Liver Antibodies  >512 publications with MAPK1/ERK2, MAPK3/ERK1 and Liver
 Kidney Antibodies  >503 publications with MAPK1/ERK2, MAPK3/ERK1 and Kidney
 Nerve Antibodies  >485 publications with MAPK1/ERK2, MAPK3/ERK1 and Nerve
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