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anti-ESR1 antibody :: Rabbit anti-Human Estrogen Receptor-alpha (Phospho-Ser305) Antibody

Scan QR to view Datasheet Catalog #    MBS001040 anti-ESR1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Estrogen Receptor-alpha (Phospho-Ser305) (ESR1), Antibody

 Also Known As   

Rabbit Estrogen Receptor-alpha (Phospho-Ser305) Antibody

 Product Synonym Names    Estrogen Receptor-a (Phospho-Ser305)
 Product Gene Name   

anti-ESR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (152011631..152424409). Location: 6q25.1
 OMIM    133430
 3D Structure    ModBase 3D Structure for P03372
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 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-ESR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ESR1 antibody   

Immunofluorescence (IF), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for ESR1. It may not necessarily be applicable to this product.
 NCBI GI #    62821794
 NCBI GeneID    2099
 NCBI Accession #    NP_000116.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000125.3 [Other Products]
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 UniProt Primary Accession #    P03372 [Other Products]
 UniProt Secondary Accession #    Q13511; Q14276; Q5T5H7; Q6MZQ9; Q9NU51; Q9UDZ7; Q9UIS7 [Other Products]
 UniProt Related Accession #    P03372 [Other Products]
 Molecular Weight    66,216 Da [Similar Products]
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 NCBI Official Full Name    estrogen receptor
 NCBI Official Synonym Full Names    estrogen receptor 1
 NCBI Official Symbol    ESR1 [Similar Products]
 NCBI Official Synonym Symbols   
ER; ESR; Era; ESRA; NR3A1
[Similar Products]
 NCBI Protein Information    estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha delta 4 +49 isoform; nuclear receptor subfamily 3 group A member 1; estrogen receptor alpha 3*,4,5,6,7*/822 isoform; estrogen receptor alpha delta 4*,5,6,7*/654 isoform; estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform; estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform; estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform
 UniProt Protein Name    Estrogen receptor
 UniProt Synonym Protein Names   
ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
 Protein Family    Estrogen receptor
 UniProt Gene Name    ESR1 [Similar Products]
 UniProt Synonym Gene Names    ESR; NR3A1; ER [Similar Products]
 UniProt Entry Name    ESR1_HUMAN
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 NCBI Summary for ESR1    This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ESR1    ER-alpha: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: nucleoplasm; Golgi apparatus; membrane; cytoplasm; integral to membrane; plasma membrane; nucleus

Molecular Function: identical protein binding; estrogen receptor activity; zinc ion binding; nitric-oxide synthase regulator activity; beta-catenin binding; estrogen response element binding; transcription factor binding; steroid binding; protein binding; enzyme binding; steroid hormone receptor activity; chromatin binding; transcription factor activity

Biological Process: estrogen receptor signaling pathway; positive regulation of nitric oxide biosynthetic process; signal transduction; uterus development; response to estradiol stimulus; regulation of apoptosis; elevation of cytosolic calcium ion concentration; positive regulation of fibroblast proliferation; regulation of transcription, DNA-dependent; epithelial cell development; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; antral ovarian follicle growth; positive regulation of nitric-oxide synthase activity; negative regulation of transcription factor activity; male gonad development; androgen metabolic process; vagina development; positive regulation of retinoic acid receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; chromatin remodeling; response to estrogen stimulus; gene expression; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)

Disease: Migraine With Or Without Aura, Susceptibility To, 1; Breast Cancer; Myocardial Infarction, Susceptibility To; Estrogen Resistance
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 Research Articles on ESR1    1. The expression of deltaEF1 is up-regulated by 17beta-estradiol (E2) in MCF-7 cells in an ER-alpha-dependent manner.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ESR1 antibodyPathways associated with anti-ESR1 antibody
 Reference Product  PubMed Publications
 ESR2 antibody  >235 publications with ESR1 and ESR2
 JUN antibody  >100 publications with ESR1 and JUN
 PGR antibody  >89 publications with ESR1 and PGR
 ERBB2 antibody  >45 publications with ESR1 and ERBB2
 BRCA1 antibody  >27 publications with ESR1 and BRCA1
 MYC antibody  >25 publications with ESR1 and MYC
 EGFR antibody  >20 publications with ESR1 and EGFR
 CCND1 antibody  >19 publications with ESR1 and CCND1
 TP53 antibody  >14 publications with ESR1 and TP53
 SP1 antibody  >11 publications with ESR1 and SP1
 Products by Pathway  Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 FOXM1 Transcription Factor Network Pathway antibodies  FOXM1 Transcription Factor Network Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with anti-ESR1 antibodyOrgans/Tissues associated with anti-ESR1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >349 publications with ESR1 and Neoplasms
 Breast Neoplasms Antibodies  >220 publications with ESR1 and Breast Neoplasms
 Female Urogenital Diseases Antibodies  >87 publications with ESR1 and Female Urogenital Diseases
 Carcinoma Antibodies  >85 publications with ESR1 and Carcinoma
 Adenocarcinoma Antibodies  >43 publications with ESR1 and Adenocarcinoma
 Disease Progression Antibodies  >38 publications with ESR1 and Disease Progression
 Bone Diseases, Metabolic Antibodies  >35 publications with ESR1 and Bone Diseases, Metabolic
 Obesity Antibodies  >32 publications with ESR1 and Obesity
 Coronary Artery Disease Antibodies  >23 publications with ESR1 and Coronary Artery Disease
 Prostatic Neoplasms Antibodies  >22 publications with ESR1 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >78 publications with ESR1 and Brain
 Uterus Antibodies  >60 publications with ESR1 and Uterus
 Ovary Antibodies  >52 publications with ESR1 and Ovary
 Heart Antibodies  >41 publications with ESR1 and Heart
 Testis Antibodies  >38 publications with ESR1 and Testis
 Prostate Antibodies  >33 publications with ESR1 and Prostate
 Muscle Antibodies  >28 publications with ESR1 and Muscle
 Connective Tissue Antibodies  >26 publications with ESR1 and Connective Tissue
 Lung Antibodies  >25 publications with ESR1 and Lung
 Lymph Node Antibodies  >17 publications with ESR1 and Lymph Node
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