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anti-Estrogen Receptor beta antibody :: Rabbit Estrogen Receptor beta Antibody

Scan QR to view Datasheet Catalog #    MBS462047
Testing Data
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Estrogen Receptor beta, Antibody

 Also Known As   

Estrogen Receptor beta

 Product Synonym Names    Rabbit anti-ER beta
 Product Gene Name   

anti-Estrogen Receptor beta antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000014.8 (64693751..64805268, complement). Location: 14q23.2
 OMIM    HIX0011730
 3D Structure    ModBase 3D Structure for Q7LCB3
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    This antibody recognizes ~53 kDa of human estrogen receptor beta. It also reacts to mouse and rat. The other species are not tested.
 Purity/Purification    The Rabbit IgG is purified by Epitope Affinity Purification.
 Form/Format    This affinity purified antibody is supplied in sterile phosphatebuffered saline (pH7.2) containing antibody stabilizer
 Concentration    Size: 100 ug/200 ul (lot specific)
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 Antigen Preparation    A synthetic peptide corresponding to the c-terminus of human Estrogen Receptor Beta.
 Positive Control    MCF-7
 Cellular Location    Nuclear
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 Preparation and Storage    The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
 Other Notes    Small volumes of anti-Estrogen Receptor beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Estrogen Receptor beta antibody

   ER (estrogen receptor) belongs to a member of the steroid receptor superfamily. It contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). The transcriptional effects of 17b-estradiol (E2) in the body are mediated by two distinct ERs, ER-alpha and ER-beta. ER-alpha plays an important role in differentiation by regulating target genes such as that for the progesterone receptor (PR). Both the stroma and epithelium express PR, and estrogen induces PR in the stromal and glandular epithelial cells. ER-alpha and ER-beta may have opposite effects on gene transcription. ER-beta can act as a transdominant repressor on ER-alpha transcriptional activity. ER-beta acts as a modulator of ER-alpha-mediated gene transcription in the uterus, and furthermore, that it is responsible for down regulation of PR in the luminal epithelium.
 Applications Tested/Suitable for anti-Estrogen Receptor beta antibody   

ELISA, Western Blot

 Application Notes for anti-Estrogen Receptor beta antibody    Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 1:200
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 Testing Data of anti-Estrogen Receptor beta antibody    anti-Estrogen Receptor beta antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for Estrogen Receptor beta. It may not necessarily be applicable to this product.
 NCBI GI #    6166154
 NCBI GeneID    2100
 NCBI Accession #    Q92731.2 [Other Products]
 NCBI GenBank Nucleotide #    Q92731 [Other Products]
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 UniProt Primary Accession #    Q7LCB3 [Other Products]
 UniProt Related Accession #    Q0PTK2; Q59F41; Q7LCB3; Q86U33; Q92731 [Other Products]
 Molecular Weight    53 kDa
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 NCBI Official Full Name    Estrogen receptor beta
 NCBI Official Synonym Full Names    estrogen receptor 2 (ER beta)
 NCBI Official Symbol    ESR2 [Similar Products]
 NCBI Official Synonym Symbols   
Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA
[Similar Products]
 NCBI Protein Information    estrogen receptor beta; OTTHUMP00000180647; estrogen receptor beta 4; estrogen nuclear receptor beta variant a; estrogen nuclear receptor beta variant b; nuclear receptor subfamily 3 group A member 2
 UniProt Protein Name    5p152
 Protein Family    Estrogen receptor
 UniProt Gene Name    ESR2 [Similar Products]
 UniProt Synonym Gene Names    NR3A2 [Similar Products]
 UniProt Entry Name    Q7LCB3_HUMAN
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 NCBI Summary for Estrogen Receptor beta    This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq]
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 UniProt Comments for Estrogen Receptor beta    Sequence similarities: Belongs to the nuclear hormone receptor family. RuleBase RU000377Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536
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Product References and Citations for anti-Estrogen Receptor beta antibody

   Zhang W et al, Estrogen receptor (ER) beta, a modulator of ER alpha in the uterus. PNAS, 97 (11): 5936-5941. 2000
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 Research Articles on Estrogen Receptor beta    1. Study provides evidence that 5-androsten-3beta,17beta-diol (ADIOL) functions as a selective modulator of estrogen receptor (ER)beta to suppress inflammatory responses of microglia and astrocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Estrogen Receptor beta antibodyPathways associated with anti-Estrogen Receptor beta antibody
 Reference Product  PubMed Publications
 ESR1 antibody  >171 publications with Estrogen Receptor beta and ESR1
 NRIP1 antibody  >4 publications with Estrogen Receptor beta and NRIP1
 SRC antibody  >2 publications with Estrogen Receptor beta and SRC
 NCOA1 antibody  >2 publications with Estrogen Receptor beta and NCOA1
 STAT5A antibody  >1 publications with Estrogen Receptor beta and STAT5A
 SP1 antibody  >1 publications with Estrogen Receptor beta and SP1
 OXT antibody  >1 publications with Estrogen Receptor beta and OXT
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
 Plasma Membrane Estrogen Receptor Signaling Pathway antibodies  Plasma Membrane Estrogen Receptor Signaling Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with anti-Estrogen Receptor beta antibodyOrgans/Tissues associated with anti-Estrogen Receptor beta antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >42 publications with Estrogen Receptor beta and Neoplasms
 Cardiovascular Diseases Antibodies  >23 publications with Estrogen Receptor beta and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >19 publications with Estrogen Receptor beta and Breast Neoplasms
 Female Urogenital Diseases Antibodies  >19 publications with Estrogen Receptor beta and Female Urogenital Diseases
 Genital Diseases, Male Antibodies  >14 publications with Estrogen Receptor beta and Genital Diseases, Male
 Male Urogenital Diseases Antibodies  >14 publications with Estrogen Receptor beta and Male Urogenital Diseases
 Nervous System Diseases Antibodies  >13 publications with Estrogen Receptor beta and Nervous System Diseases
 Osteoporosis Antibodies  >12 publications with Estrogen Receptor beta and Osteoporosis
 Gonadal Disorders Antibodies  >11 publications with Estrogen Receptor beta and Gonadal Disorders
 Infertility Antibodies  >10 publications with Estrogen Receptor beta and Infertility
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >46 publications with Estrogen Receptor beta and Blood
 Bone Antibodies  >28 publications with Estrogen Receptor beta and Bone
 Ovary Antibodies  >24 publications with Estrogen Receptor beta and Ovary
 Brain Antibodies  >19 publications with Estrogen Receptor beta and Brain
 Testis Antibodies  >13 publications with Estrogen Receptor beta and Testis
 Prostate Antibodies  >12 publications with Estrogen Receptor beta and Prostate
 Vascular Antibodies  >11 publications with Estrogen Receptor beta and Vascular
 Uterus Antibodies  >9 publications with Estrogen Receptor beta and Uterus
 Heart Antibodies  >8 publications with Estrogen Receptor beta and Heart
 Liver Antibodies  >6 publications with Estrogen Receptor beta and Liver
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