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anti-FAK antibody :: Rabbit FAK (Ab-407) Antibody

Scan QR to view Datasheet Catalog #    MBS004639
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FAK (Ab-407), Antibody

★Popular Item★
 Also Known As   

Rabbit FAK (Ab-407) Antibody

 Product Synonym Names    EC 2.7.10.2, FADK 1, FAK1, Focal adhesion kinase 1, PTK2, Protein- tyrosine kinase 2, pp125FAK
 Product Gene Name   

anti-FAK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 8; NC_000008.10 (141668481..142011412, complement). Location: 8q24.3
 OMIM    600758
 3D Structure    ModBase 3D Structure for Q05397
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Specificity    FAK (Ab-407) antibody detects endogenous levels of total FAK protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1 mg/ml (lot specific)
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-FAK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FAK antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-FAK antibody    WB: 1:500-1:1000
IHC: 1:50-1:100
ELISA: 1:5000
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 Immnunohistochemistry of anti-FAK antibody    anti-FAK antibody Immnunohistochemistry image
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 Western Blot of anti-FAK antibody    anti-FAK antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for FAK. It may not necessarily be applicable to this product.
 NCBI GI #    313851044
 NCBI GeneID    5747
 NCBI Accession #    NP_001186578.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199649.1 [Other Products]
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 UniProt Primary Accession #    Q05397 [Other Products]
 UniProt Secondary Accession #    Q14291; Q9UD85; B4E2N6; F5H4S4 [Other Products]
 UniProt Related Accession #    Q05397 [Other Products]
 Molecular Weight    119,233 Da
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 NCBI Official Full Name    focal adhesion kinase 1 isoform c
 NCBI Official Synonym Full Names    protein tyrosine kinase 2
 NCBI Official Symbol    PTK2 [Similar Products]
 NCBI Official Synonym Symbols   
FAK; FADK; FAK1; FRNK; PPP1R71; p125FAK; pp125FAK
[Similar Products]
 NCBI Protein Information    focal adhesion kinase 1; FADK 1; PTK2 protein tyrosine kinase 2; FAK-related non-kinase polypeptide; focal adhesion kinase-related nonkinase; protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71
 UniProt Protein Name    Focal adhesion kinase 1
 UniProt Synonym Protein Names   
Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK
 UniProt Gene Name    PTK2 [Similar Products]
 UniProt Synonym Gene Names    FAK; FAK1; FADK 1; FRNK; PPP1R71 [Similar Products]
 UniProt Entry Name    FAK1_HUMAN
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 NCBI Summary for FAK    This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]
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 UniProt Comments for FAK    FAK: a tyrosine kinase of the FAK family required for cell migration and contact-dependent survival signaling. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Downstream of integrins and Src, upstream of Ras/MAPK. Localizes to focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with Shb. Required for full Ras transformation of fibroblasts. Increased expression in breast and other cancers, related to chromosome 8q amplification. Overexpression and activation associated with increased migration, invasion and progression of ovarian cancer, and with progression in hepatocellular carcinoma, thyroid cancer, and acute myelogenous leukemia. siRNA increases chemosensitivity of pancreatic adenocarcinoma xenografts. Inhibitor: ISI15421 (antisense). Four splice-variant isoforms have been observed.

Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; TK group; Fak family

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; focal adhesion; lamellipodium; apical plasma membrane; cytoplasm; plasma membrane; stress fiber; microtubule organizing center; cell cortex; nucleus; cytosol

Molecular Function: JUN kinase binding; protein binding; signal transducer activity; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; SH2 domain binding; actin binding; protein kinase binding; ATP binding; receptor binding; protein kinase activity

Biological Process: heart morphogenesis; axon guidance; extracellular matrix organization and biogenesis; establishment of nucleus localization; peptidyl-tyrosine phosphorylation; apoptosis; protein amino acid autophosphorylation; cell motility involved in cell locomotion; neuron migration; negative regulation of synaptogenesis; regulation of cell shape; regulation of cell adhesion mediated by integrin; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; ephrin receptor signaling pathway; negative regulation of axonogenesis; angiogenesis; vasculogenesis; cell structure disassembly during apoptosis; placenta development; epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; platelet activation; regulation of osteoblast differentiation; central nervous system neuron axonogenesis; signal complex assembly; positive regulation of phosphoinositide 3-kinase activity; cytoskeleton organization and biogenesis; microtubule cytoskeleton organization and biogenesis; negative regulation of organ growth; regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; embryonic development; establishment of cell polarity; positive regulation of protein kinase activity; regulation of focal adhesion formation; endothelial cell migration; innate immune response; positive regulation of protein amino acid phosphorylation; negative regulation of cell-cell adhesion; blood coagulation; vascular endothelial growth factor receptor signaling pathway; regulation of cytoskeleton organization and biogenesis; positive regulation of cell migration; negative regulation of apoptosis
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 Research Articles on FAK    1. Tyr-397 phosphorylation, rather than kinase activity of FAK, is the key determinant of cell migration
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FAK antibodyPathways associated with anti-FAK antibody
 Reference Product  PubMed Publications
 SRC antibody  >574 publications with FAK and SRC
 CRK antibody  >151 publications with FAK and CRK
 BCAR1 antibody  >102 publications with FAK and BCAR1
 FYN antibody  >69 publications with FAK and FYN
 PTK2B antibody  >64 publications with FAK and PTK2B
 GRB2 antibody  >59 publications with FAK and GRB2
 EGFR antibody  >48 publications with FAK and EGFR
 CSK antibody  >48 publications with FAK and CSK
 SYK antibody  >25 publications with FAK and SYK
 PTPN11 antibody  >25 publications with FAK and PTPN11
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
Diseases associated with anti-FAK antibodyOrgans/Tissues associated with anti-FAK antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >757 publications with FAK and Neoplasms
 Neoplasm Invasiveness Antibodies  >176 publications with FAK and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >152 publications with FAK and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >116 publications with FAK and Breast Neoplasms
 Lung Diseases Antibodies  >77 publications with FAK and Lung Diseases
 Neoplasms, Experimental Antibodies  >76 publications with FAK and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >74 publications with FAK and Lung Neoplasms
 Liver Diseases Antibodies  >72 publications with FAK and Liver Diseases
 Liver Neoplasms Antibodies  >70 publications with FAK and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >69 publications with FAK and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >360 publications with FAK and Vascular
 Blood Antibodies  >309 publications with FAK and Blood
 Muscle Antibodies  >225 publications with FAK and Muscle
 Brain Antibodies  >161 publications with FAK and Brain
 Kidney Antibodies  >150 publications with FAK and Kidney
 Lung Antibodies  >126 publications with FAK and Lung
 Bone Antibodies  >118 publications with FAK and Bone
 Liver Antibodies  >113 publications with FAK and Liver
 Embryonic Tissue Antibodies  >94 publications with FAK and Embryonic Tissue
 Heart Antibodies  >84 publications with FAK and Heart
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