NP_006320.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,180 Da
NCBI Official Full Name
fibulin-5
NCBI Official Synonym Full Names
fibulin 5
NCBI Official Synonym Symbols
EVEC; UP50; ADCL2; ARMD3; DANCE; ARCL1A; FIBL-5; HNARMD [Similar Products]
NCBI Protein Information
fibulin-5
UniProt Protein Name
Fibulin-5
UniProt Synonym Protein Names
Developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50
UniProt Synonym Gene Names
NCBI Summary for FBLN5
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
UniProt Comments for FBLN5
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).
Product References and Citations for anti-FBLN5 antibody
Hwang S.-Y., Mol. Cells 10:584-591(2000). Cannon G., Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. Nagase T., DNA Res. 7:65-73(2000).
Research Articles on FBLN5
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Products associated with anti-FBLN5 antibody
Pathways associated with anti-FBLN5 antibody
Diseases associated with anti-FBLN5 antibody
Organs/Tissues associated with anti-FBLN5 antibody
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