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anti-FLT1 antibody :: Mouse anti-Human FLT1 Antibody

Scan QR to view Datasheet Catalog #    MBS850439
Western Blot (WB)
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FLT1, Antibody

 Also Known As   

FLT1 Antibody

 Product Synonym Names    FLT; VEGFR1
 Product Gene Name   

anti-FLT1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    165070
 3D Structure    ModBase 3D Structure for P17948
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 Isotype    IgG1
 Clone Number    3D10
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant extracellular fragment of human FLT1 fused with hIgGFc tag expressed in HEK293 cells.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C
 Other Notes    Small volumes of anti-FLT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FLT1 antibody

   Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), also known as FLT1 or VEGFR-1. It is a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
 Product Categories/Family for anti-FLT1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-FLT1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-FLT1 antibody    WB: 1:500-1:2000
ELISA: 1:10000
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 Western Blot (WB) of anti-FLT1 antibody    Figure 1. Western blot analysis using FLT1 mouse mAb against extracellular domain of human FLT1.
anti-FLT1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for FLT1. It may not necessarily be applicable to this product.
 NCBI GI #    229892220
 NCBI GeneID    2321
 NCBI Accession #    NP_001153392.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001159920.1 [Other Products]
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 UniProt Primary Accession #    P17948 [Other Products]
 UniProt Secondary Accession #    O60722; A3E342; A3E344; A8KA71; B0LPF1; B2BF46; B2BF47; B2BF48; B3FR89; B5A923; F5H5L6 [Other Products]
 UniProt Related Accession #    P17948 [Other Products]
 Molecular Weight    100kDa
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 NCBI Official Full Name    vascular endothelial growth factor receptor 1 isoform 2
 NCBI Official Synonym Full Names    fms related tyrosine kinase 1
 NCBI Official Symbol    FLT1 [Similar Products]
 NCBI Official Synonym Symbols   
FLT; FLT-1; VEGFR1; VEGFR-1
[Similar Products]
 NCBI Protein Information    vascular endothelial growth factor receptor 1
 UniProt Protein Name    Vascular endothelial growth factor receptor 1
 UniProt Synonym Protein Names   
Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; FLT; Vascular permeability factor receptor
 Protein Family    Vascular endothelial growth factor receptor
 UniProt Gene Name    FLT1 [Similar Products]
 UniProt Synonym Gene Names    FLT; FRT; VEGFR1; VEGFR-1; FLT-1; FLT [Similar Products]
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 NCBI Summary for FLT1    This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
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 UniProt Comments for FLT1    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.
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 Research Articles on FLT1    1. The VEGF/sVEGF-R1 ratio in follicular fluid on the day of oocyte retrieval in women undergoing IVF procedure, regardless of the type of stimulation protocol, might predict the risk of developing ovarian hyperstimulation syndrome (OHSS). To the best of our knowledge this is the first paper in the literature to show interplay among VEGF, EG-VEGF and sVEGF-R1 and the correlation between their concentration and OHSS risk.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FLT1 antibodyPathways associated with anti-FLT1 antibody
 Reference Product  PubMed Publications
 KDR antibody  >173 publications with FLT1 and KDR
 VEGFA antibody  >125 publications with FLT1 and VEGFA
 PGF antibody  >15 publications with FLT1 and PGF
 NRP1 antibody  >8 publications with FLT1 and NRP1
 VEGFB antibody  >8 publications with FLT1 and VEGFB
 CTNNB1 antibody  >5 publications with FLT1 and CTNNB1
 PTK2 antibody  >4 publications with FLT1 and PTK2
 FYN antibody  >3 publications with FLT1 and FYN
 PTK2B antibody  >2 publications with FLT1 and PTK2B
 NRP2 antibody  >2 publications with FLT1 and NRP2
 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Glypican 1 Network Pathway antibodies  Glypican 1 Network Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
Diseases associated with anti-FLT1 antibodyOrgans/Tissues associated with anti-FLT1 antibody
 Disease Name  Pubmed Publications
 Pre-Eclampsia Antibodies  >232 publications with FLT1 and Pre-Eclampsia
 Neoplasms Antibodies  >202 publications with FLT1 and Neoplasms
 Hypertension Antibodies  >93 publications with FLT1 and Hypertension
 Proteinuria Antibodies  >55 publications with FLT1 and Proteinuria
 Inflammation Antibodies  >42 publications with FLT1 and Inflammation
 Nervous System Diseases Antibodies  >41 publications with FLT1 and Nervous System Diseases
 Adenocarcinoma Antibodies  >35 publications with FLT1 and Adenocarcinoma
 Necrosis Antibodies  >31 publications with FLT1 and Necrosis
 Brain Diseases Antibodies  >31 publications with FLT1 and Brain Diseases
 Neoplasms, Experimental Antibodies  >28 publications with FLT1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >873 publications with FLT1 and Vascular
 Blood Antibodies  >494 publications with FLT1 and Blood
 Placenta Antibodies  >267 publications with FLT1 and Placenta
 Embryonic Tissue Antibodies  >115 publications with FLT1 and Embryonic Tissue
 Muscle Antibodies  >81 publications with FLT1 and Muscle
 Bone Antibodies  >75 publications with FLT1 and Bone
 Liver Antibodies  >64 publications with FLT1 and Liver
 Lung Antibodies  >58 publications with FLT1 and Lung
 Kidney Antibodies  >51 publications with FLT1 and Kidney
 Eye Antibodies  >49 publications with FLT1 and Eye
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