Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow FLT3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • HOXA6 Antibody
 • OR51A4 Antibody
 • CDH10 Antibody
 • Heat Shock 70Kda Protein 4 (HSPA4) ELISA Kit
 • Teichoic Acid Antibody (TA) ELISA Kit
 • Poly Serium Antigen (PHSA) ELISA Kit
 • Dermato-Pontin (DPT) ELISA Kit
 • Macrophage Inflammatory Protein-3alpha (MIP-3alpha) ELISA Kit
 • Cobra Venom Neuronal Protective Factor (CVNPE) ELISA Kit
 • Monocyte Chemotactic Protein 4 (MCP-4) ELISA Kit
 • Fibromodulin (FMOD) ELISA Kit
 • Apolipoprotein Antibodies (AHA) ELISA Kit
 • Procollagen Type I C-Terminal Propeptide (PICP) ELISA Kit
 • Pl12-Antibody ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-FLT3 antibody :: Rabbit anti-Human, mouse FLT3 (Ab-599) Antibody

Scan QR to view Datasheet Catalog #    MBS003049 anti-FLT3 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FLT3 (Ab-599), Antibody

 Also Known As   

Rabbit FLT3 (Ab-599) Antibody

 Product Gene Name   

anti-FLT3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 13; NC_000013.10 (28577411..28674729, complement). Location: 13q12
 OMIM    136351
 3D Structure    ModBase 3D Structure for P36888
Section Bar
 Host    Rabbit
 Species Reactivity    Human, mouse
Section Bar
 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
Section Bar
Section Bar
 Other Notes    Small volumes of anti-FLT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-FLT3 antibody   

ELISA (EIA), Western Blot (WB)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for FLT3. It may not necessarily be applicable to this product.
 NCBI GI #    121114304
 NCBI GeneID    2322
 NCBI Accession #    NP_004110.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004119.2 [Other Products]
Section Bar
 UniProt Primary Accession #    P36888 [Other Products]
 UniProt Secondary Accession #    Q13414; A0AVG9; B7ZLT7; B7ZLT8; F5H0A0 [Other Products]
 UniProt Related Accession #    P36888 [Other Products]
 Molecular Weight    112,903 Da
Table BarTOPTable Bar
 NCBI Official Full Name    receptor-type tyrosine-protein kinase FLT3
 NCBI Official Synonym Full Names    fms-related tyrosine kinase 3
 NCBI Official Symbol    FLT3 [Similar Products]
 NCBI Official Synonym Symbols   
FLK2; STK1; CD135; FLK-2
[Similar Products]
 NCBI Protein Information    receptor-type tyrosine-protein kinase FLT3; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III
 UniProt Protein Name    Receptor-type tyrosine-protein kinase FLT3
 UniProt Synonym Protein Names   
FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1
 Protein Family    Receptor-type tyrosine-protein kinase
 UniProt Gene Name    FLT3 [Similar Products]
 UniProt Synonym Gene Names    CD135; FLK2; STK1; FLK-2; FLT-3; STK-1 [Similar Products]
 UniProt Entry Name    FLT3_HUMAN
Section Bar
 NCBI Summary for FLT3    This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for FLT3    FLT3: a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412.

Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; Oncoprotein; Kinase, protein; EC 2.7.10.1; TK group; PDGFR family

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: protein complex; integral to plasma membrane; endoplasmic reticulum lumen; cytosol; nucleus; external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; vascular endothelial growth factor receptor activity; protein binding; protein homodimerization activity; protein complex binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding; glucocorticoid receptor binding

Biological Process: negative regulation of B cell differentiation; pro-B cell differentiation; lymphocyte proliferation; organ regeneration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; positive regulation of phosphoinositide 3-kinase activity; response to organic nitrogen; positive regulation of phosphoinositide 3-kinase cascade; regulation of apoptosis; positive regulation of MAP kinase activity; negative regulation of cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; myeloid progenitor cell differentiation; positive regulation of MAPKKK cascade; B cell differentiation; positive regulation of cell proliferation; hemopoiesis; pro-T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; leukocyte homeostasis

Disease: Leukemia, Acute Lymphoblastic
Table BarTOPTable Bar
 Research Articles on FLT3    1. Data suggest that FLT3 internal tandem duplication mutations result in overall poor prognosis in acute myeloid leukemia patients.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-FLT3 antibodyPathways associated with anti-FLT3 antibody
 Reference Product  PubMed Publications
 GRB2 antibody  >7 publications with FLT3 and GRB2
 FIZ1 antibody  >7 publications with FLT3 and FIZ1
 SOCS1 antibody  >7 publications with FLT3 and SOCS1
 PTPN6 antibody  >6 publications with FLT3 and PTPN6
 FLT3LG antibody  >4 publications with FLT3 and FLT3LG
 CBLB antibody  >4 publications with FLT3 and CBLB
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with anti-FLT3 antibodyOrgans/Tissues associated with anti-FLT3 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1788 publications with FLT3 and Neoplasms
 Leukemia, Myeloid, Acute Antibodies  >1489 publications with FLT3 and Leukemia, Myeloid, Acute
 Bone Marrow Diseases Antibodies  >264 publications with FLT3 and Bone Marrow Diseases
 Cell Transformation, Neoplastic Antibodies  >137 publications with FLT3 and Cell Transformation, Neoplastic
 Leukemia, Promyelocytic, Acute Antibodies  >125 publications with FLT3 and Leukemia, Promyelocytic, Acute
 Necrosis Antibodies  >113 publications with FLT3 and Necrosis
 Neoplasms, Experimental Antibodies  >91 publications with FLT3 and Neoplasms, Experimental
 Carcinoma Antibodies  >85 publications with FLT3 and Carcinoma
 Inflammation Antibodies  >69 publications with FLT3 and Inflammation
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >66 publications with FLT3 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1619 publications with FLT3 and Blood
 Bone Marrow Antibodies  >965 publications with FLT3 and Bone Marrow
 Lung Antibodies  >78 publications with FLT3 and Lung
 Thymus Antibodies  >66 publications with FLT3 and Thymus
 Brain Antibodies  >58 publications with FLT3 and Brain
 Kidney Antibodies  >36 publications with FLT3 and Kidney
 Intestine Antibodies  >18 publications with FLT3 and Intestine
 Testis Antibodies  >5 publications with FLT3 and Testis
 Stomach Antibodies  >2 publications with FLT3 and Stomach
 Bladder Antibodies  >2 publications with FLT3 and Bladder
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions