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anti-FLT3 antibody :: anti-Human, Mouse FLT3 Antibody

Scan QR to view Datasheet Catalog #    MBS851371
Western Blot (WB)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FLT3, Antibody

★Popular Item★
 Also Known As   

FLT3 (Phospho-Tyr842) Antibody

 Product Synonym Names    CD135; EC 2.7.10.1; fetal liver kinase 2; FL cytokine receptor; FLK-2; FLT-3; FLT3; fms-related tyrosine kinase 3; kinase Flt3; stem cell tyrosine kinase 1; STK-1; STK1
 Product Gene Name   

anti-FLT3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    136351
 3D Structure    ModBase 3D Structure for P36888
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 Species Reactivity    Human, Mouse
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 Specificity    FLT3 (Phospho-Tyr842) antibody detects endogenous levels of FLT3 only when phosphorylated at tyrosine 842.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human FLT3 around the phosphorylation site of tyrosine 842 (S-N-YP-V-V).
 All Sites    Human: Tyr842
Mouse: Tyr845
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-FLT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-FLT3 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-FLT3 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-FLT3 antibody    WB: 1:500-1:1000
ELISA: 1:10000
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 Western Blot (WB) of anti-FLT3 antibody    Western blot analysis of extracts from HepG2 cells, treated with EGF (200ng/ml, 30mins), using FLT3 (Phospho-Tyr842)) antibody.
anti-FLT3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for FLT3. It may not necessarily be applicable to this product.
 NCBI GI #    121114304
 NCBI GeneID    2322
 NCBI Accession #    NP_004110.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004119.2 [Other Products]
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 UniProt Primary Accession #    P36888 [Other Products]
 UniProt Secondary Accession #    Q13414; A0AVG9; B7ZLT7; B7ZLT8; F5H0A0 [Other Products]
 UniProt Related Accession #    P36888 [Other Products]
 Molecular Weight    108,378 Da
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 NCBI Official Full Name    receptor-type tyrosine-protein kinase FLT3
 NCBI Official Synonym Full Names    fms related tyrosine kinase 3
 NCBI Official Symbol    FLT3 [Similar Products]
 NCBI Official Synonym Symbols   
FLK2; STK1; CD135; FLK-2
[Similar Products]
 NCBI Protein Information    receptor-type tyrosine-protein kinase FLT3
 UniProt Protein Name    Receptor-type tyrosine-protein kinase FLT3
 UniProt Synonym Protein Names   
FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen: CD135
 Protein Family    Flt3 receptor-interacting lectin
 UniProt Gene Name    FLT3 [Similar Products]
 UniProt Synonym Gene Names    CD135; FLK2; STK1; FLK-2; FLT-3; STK-1 [Similar Products]
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 NCBI Summary for FLT3    This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
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 UniProt Comments for FLT3    Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
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Product References and Citations for anti-FLT3 antibody

   Small D., Proc. Natl. Acad. Sci. U.S.A. 91:459-463(1994). Rosnet O., Blood 82:1110-1119(1993). Rosnet O., Genomics 9:380-385(1991).
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 Research Articles on FLT3    1. The high expressions of BCRP mRNA calculated with Pfaffl's rule and FLT3-ITD are independent poor risk factors in adult patients with AML and intermediate or normal karyotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FLT3 antibodyPathways associated with anti-FLT3 antibody
 Reference Product  PubMed Publications
 GRB2 antibody  >7 publications with FLT3 and GRB2
 FIZ1 antibody  >7 publications with FLT3 and FIZ1
 SOCS1 antibody  >7 publications with FLT3 and SOCS1
 PTPN6 antibody  >6 publications with FLT3 and PTPN6
 FLT3LG antibody  >4 publications with FLT3 and FLT3LG
 CBLB antibody  >4 publications with FLT3 and CBLB
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with anti-FLT3 antibodyOrgans/Tissues associated with anti-FLT3 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1788 publications with FLT3 and Neoplasms
 Leukemia, Myeloid, Acute Antibodies  >1489 publications with FLT3 and Leukemia, Myeloid, Acute
 Bone Marrow Diseases Antibodies  >264 publications with FLT3 and Bone Marrow Diseases
 Cell Transformation, Neoplastic Antibodies  >137 publications with FLT3 and Cell Transformation, Neoplastic
 Leukemia, Promyelocytic, Acute Antibodies  >125 publications with FLT3 and Leukemia, Promyelocytic, Acute
 Necrosis Antibodies  >113 publications with FLT3 and Necrosis
 Neoplasms, Experimental Antibodies  >91 publications with FLT3 and Neoplasms, Experimental
 Carcinoma Antibodies  >85 publications with FLT3 and Carcinoma
 Inflammation Antibodies  >69 publications with FLT3 and Inflammation
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >66 publications with FLT3 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1619 publications with FLT3 and Blood
 Bone Marrow Antibodies  >965 publications with FLT3 and Bone Marrow
 Lung Antibodies  >78 publications with FLT3 and Lung
 Thymus Antibodies  >66 publications with FLT3 and Thymus
 Brain Antibodies  >58 publications with FLT3 and Brain
 Kidney Antibodies  >36 publications with FLT3 and Kidney
 Intestine Antibodies  >18 publications with FLT3 and Intestine
 Testis Antibodies  >5 publications with FLT3 and Testis
 Stomach Antibodies  >2 publications with FLT3 and Stomach
 Bladder Antibodies  >2 publications with FLT3 and Bladder
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