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anti-FOXO3 antibody :: Rabbit FOXO3-S253 Antibody

Scan QR to view Datasheet Catalog #    MBS128272
Western Blot (WB)
Unit / Price
0.05 mL  /  $265 +1 FREE 8GB USB
0.1 mL  /  $380 +1 FREE 8GB USB
0.2 mL  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FOXO3-S253, Antibody

★Popular Item★
 Also Known As   

Phospho-FOXO3-S253 Polyclonal Antibody

 Product Synonym Names    Phospho-FOXO3-S253: FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
 Product Gene Name   

anti-FOXO3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602681
 3D Structure    ModBase 3D Structure for O43524
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Route    Synthetic Peptide
 Category    Primary antibody
 Immunogen    A phospho specific peptide corresponding to residues surrounding S253 of human FOXO3
 Calculated MW    48kDa/71kDa
 Observed MW    100kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-FOXO3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FOXO3 antibody

   This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
 Product Categories/Family for anti-FOXO3 antibody    Phosphorylation
 Applications Tested/Suitable for anti-FOXO3 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-FOXO3 antibody    WB: 1:500 - 1:1000
IHC: 1:50 - 1:100
IF: 1:50 - 1:200
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 Western Blot (WB) of anti-FOXO3 antibody    Western blot analysis of extracts of Untreated and treated 293 cell line, using Phospho-FOXO3-S253 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% BSA.
anti-FOXO3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for FOXO3. It may not necessarily be applicable to this product.
 NCBI GI #    8134467
 NCBI GeneID    2309
 NCBI Accession #    O43524.1 [Other Products]
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 UniProt Primary Accession #    O43524 [Other Products]
 UniProt Secondary Accession #    O15171; Q5T2I7; Q9BZ04; B4DVZ6; E1P5E6 [Other Products]
 UniProt Related Accession #    O43524 [Other Products]
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 NCBI Official Full Name    Forkhead box protein O3
 NCBI Official Synonym Full Names    forkhead box O3
 NCBI Official Symbol    FOXO3 [Similar Products]
 NCBI Official Synonym Symbols   
FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
[Similar Products]
 NCBI Protein Information    forkhead box protein O3; forkhead box O3A; forkhead in rhabdomyosarcoma-like 1; forkhead homolog (rhabdomyosarcoma) like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
 UniProt Protein Name    Forkhead box protein O3
 UniProt Synonym Protein Names   
AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1
 Protein Family    Forkhead box protein
 UniProt Gene Name    FOXO3 [Similar Products]
 UniProt Synonym Gene Names    FKHRL1; FOXO3A [Similar Products]
 UniProt Entry Name    FOXO3_HUMAN
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 NCBI Summary for FOXO3    This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FOXO3    FOXO3A: a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia.

Protein type: Oncoprotein; DNA-binding; Transcription factor; Autophagy

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; DNA binding; chromatin DNA binding; sequence-specific DNA binding; transcription factor activity; protein kinase binding

Biological Process: epidermal growth factor receptor signaling pathway; transcription from RNA polymerase II promoter; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator; nerve growth factor receptor signaling pathway; initiation of primordial ovarian follicle growth; positive regulation of transcription, DNA-dependent; antral ovarian follicle growth; positive regulation of erythrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; ovulation from ovarian follicle; oocyte maturation; regulation of translation; regulation of transcription from RNA polymerase II promoter; positive regulation of neuron apoptosis; innate immune response; positive regulation of transcription from RNA polymerase II promoter
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 Research Articles on FOXO3    1. Decreased FOXO3A levels are associated with idiopathic pulmonary fibrosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FOXO3 antibodyPathways associated with anti-FOXO3 antibody
 Reference Product  PubMed Publications
 SIRT1 antibody  >68 publications with FOXO3 and SIRT1
 AKT1 antibody  >63 publications with FOXO3 and AKT1
 CTNNB1 antibody  >23 publications with FOXO3 and CTNNB1
 IKBKB antibody  >18 publications with FOXO3 and IKBKB
 SMAD2 antibody  >7 publications with FOXO3 and SMAD2
 SMAD4 antibody  >6 publications with FOXO3 and SMAD4
 BCL2L11 antibody  >4 publications with FOXO3 and BCL2L11
 YWHAZ antibody  >1 publications with FOXO3 and YWHAZ
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Nucleus Pathway antibodies  AKT Phosphorylates Targets In The Nucleus Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
Diseases associated with anti-FOXO3 antibodyOrgans/Tissues associated with anti-FOXO3 antibody
 Disease Name  Pubmed Publications
 Atrophy Antibodies  >87 publications with FOXO3 and Atrophy
 Inflammation Antibodies  >60 publications with FOXO3 and Inflammation
 Breast Neoplasms Antibodies  >59 publications with FOXO3 and Breast Neoplasms
 Disease Models, Animal Antibodies  >58 publications with FOXO3 and Disease Models, Animal
 Necrosis Antibodies  >52 publications with FOXO3 and Necrosis
 Adenocarcinoma Antibodies  >48 publications with FOXO3 and Adenocarcinoma
 Heart Diseases Antibodies  >36 publications with FOXO3 and Heart Diseases
 Hypertrophy Antibodies  >29 publications with FOXO3 and Hypertrophy
 Liver Diseases Antibodies  >28 publications with FOXO3 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >27 publications with FOXO3 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >196 publications with FOXO3 and Muscle
 Blood Antibodies  >187 publications with FOXO3 and Blood
 Brain Antibodies  >78 publications with FOXO3 and Brain
 Heart Antibodies  >73 publications with FOXO3 and Heart
 Liver Antibodies  >68 publications with FOXO3 and Liver
 Vascular Antibodies  >65 publications with FOXO3 and Vascular
 Lung Antibodies  >62 publications with FOXO3 and Lung
 Bone Antibodies  >46 publications with FOXO3 and Bone
 Ovary Antibodies  >40 publications with FOXO3 and Ovary
 Prostate Antibodies  >36 publications with FOXO3 and Prostate
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