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anti-FYN antibody :: Mouse anti-Human FYN Antibody

Scan QR to view Datasheet Catalog #    MBS850994
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FYN, Antibody

 Also Known As   

FYN Antibody

 Product Synonym Names    SLK; SYN; MGC45350
 Product Gene Name   

anti-FYN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137025
 3D Structure    ModBase 3D Structure for P06241
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 Isotype    IgG1
 Clone Number    2A10
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of human FYN expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C.
 Other Notes    Small volumes of anti-FYN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FYN antibody

   This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
 Product Categories/Family for anti-FYN antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-FYN antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA)

 Application Notes for anti-FYN antibody    WB: 1:500-1:2000
IHC: 1:200-1:1000
IF: 1:200-1:1000
FC: 1:200-1:400
ELISA: 1:10000
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 Western Blot (WB) of anti-FYN antibody    Figure 1: Western blot analysis using FYN mouse mAb against Hela cell lysate.
anti-FYN antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-FYN antibody    Figure 2: Immunohistochemical analysis of paraffin-embedded breast cancer tissues (left) and brain tissues (right) using FYN mouse mAb with DAB staining.
anti-FYN antibody Immunohistochemistry (IHC) (IHC) image
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 Testing Data of anti-FYN antibody    anti-FYN antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for FYN. It may not necessarily be applicable to this product.
 NCBI GI #    4503823
 NCBI GeneID    2534
 NCBI Accession #    NP_002028.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002037.5 [Other Products]
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 UniProt Primary Accession #    P06241 [Other Products]
 UniProt Secondary Accession #    Q16248; Q5R3A6; Q5R3A7; Q8N5D7; B5BU57; E1P557; H0UI48 [Other Products]
 UniProt Related Accession #    P06241 [Other Products]
 Molecular Weight    61kDa
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 NCBI Official Full Name    tyrosine-protein kinase Fyn isoform a
 NCBI Official Synonym Full Names    FYN proto-oncogene, Src family tyrosine kinase
 NCBI Official Symbol    FYN [Similar Products]
 NCBI Official Synonym Symbols   
SLK; SYN; p59-FYN
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase Fyn
 UniProt Protein Name    Tyrosine-protein kinase Fyn
 UniProt Synonym Protein Names   
Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn
 Protein Family    FYN-binding protein
 UniProt Gene Name    FYN [Similar Products]
 UniProt Synonym Gene Names    SLK [Similar Products]
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 NCBI Summary for FYN    This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FYN    Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
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 Research Articles on FYN    1. Fyn-dependent phosphorylation of SHP-1 serine 591 inactivates the phosphatase, enabling activatory immunoreceptor signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FYN antibodyPathways associated with anti-FYN antibody
 Reference Product  PubMed Publications
 CSK antibody  >150 publications with FYN and CSK
 GRB2 antibody  >91 publications with FYN and GRB2
 PTPRC antibody  >76 publications with FYN and PTPRC
 PTK2 antibody  >69 publications with FYN and PTK2
 CBL antibody  >65 publications with FYN and CBL
 CRK antibody  >58 publications with FYN and CRK
 NCAM1 antibody  >50 publications with FYN and NCAM1
 FYB antibody  >43 publications with FYN and FYB
 PTPN11 antibody  >35 publications with FYN and PTPN11
 SH2D1A antibody  >34 publications with FYN and SH2D1A
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
Diseases associated with anti-FYN antibodyOrgans/Tissues associated with anti-FYN antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >324 publications with FYN and Neoplasms
 Nervous System Diseases Antibodies  >155 publications with FYN and Nervous System Diseases
 Brain Diseases Antibodies  >105 publications with FYN and Brain Diseases
 Inflammation Antibodies  >62 publications with FYN and Inflammation
 Cell Transformation, Neoplastic Antibodies  >45 publications with FYN and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >40 publications with FYN and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >40 publications with FYN and Breast Neoplasms
 Drug Toxicity Antibodies  >34 publications with FYN and Drug Toxicity
 Necrosis Antibodies  >34 publications with FYN and Necrosis
 Pain Antibodies  >30 publications with FYN and Pain
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >751 publications with FYN and Blood
 Brain Antibodies  >410 publications with FYN and Brain
 Vascular Antibodies  >101 publications with FYN and Vascular
 Muscle Antibodies  >88 publications with FYN and Muscle
 Kidney Antibodies  >78 publications with FYN and Kidney
 Thymus Antibodies  >75 publications with FYN and Thymus
 Lung Antibodies  >57 publications with FYN and Lung
 Embryonic Tissue Antibodies  >50 publications with FYN and Embryonic Tissue
 Spleen Antibodies  >49 publications with FYN and Spleen
 Liver Antibodies  >44 publications with FYN and Liver
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